Patents by Inventor Luisa ANDRUZZI
Luisa ANDRUZZI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230407391Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: ApplicationFiled: June 14, 2023Publication date: December 21, 2023Inventors: Steven M. MENCHEN, Alan BLANCHARD, Luisa ANDRUZZI, Shaheer KHAN, Dmitriy GREMYACHINSKIY, Alfred LUI, Craig STOLARCZYK, Tanya SOKOLSKY, Prasanna Krishnan THWAR
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Patent number: 11821032Abstract: The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3?-O position capped by a disulfide-based 3?-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: GrantFiled: August 21, 2020Date of Patent: November 21, 2023Assignee: IsoPlexis CorporationInventors: Luisa Andruzzi, Jimmy Adediran, Timothy Pelletier, Austin Ricker, Angela DeLucia, Ben McNally, Dona Hevroni, Mong Sano Marma, John Andrew Sheridan
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Publication number: 20230340583Abstract: The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3?-O position capped by a disulfide-based 3?-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: ApplicationFiled: April 6, 2023Publication date: October 26, 2023Inventors: Luisa ANDRUZZI, Jimmy ADEDIRAN, Timothy PELLETIER, Austin RICKER, Angela DELUCIA, Ben MCNALLY, Dona HEVRONI, Mong Sano MARMA, John Andrew SHERIDAN
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Publication number: 20230333013Abstract: Technology described herein includes a method that includes providing, by an optical light source, a light beam configured to traverse an optical path through a fluid comprising the biological sample in a container. A length of the optical path through the fluid is between 3.3 mm to 5.5 mm, and a center of the light beam is at a height less than 1.6 mm from a bottom interior surface of the container, and a volume of the fluid is less than 120 ?L. An optical detector receives optical information after the light beam traverses the optical path. An output of the optical detector is associated with at least one parameter representing the one or more characteristics of the biological sample.Type: ApplicationFiled: April 15, 2022Publication date: October 19, 2023Inventors: Ethan F. Schonbrun, Christopher Farren, Paul C. McCormack, Luisa Andruzzi
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Publication number: 20230314405Abstract: An example method includes: analyzing a clot curve for a test sample that is based on an assay performed on the test sample in order to obtain two or more parameters associated with the clot curve; analyzing the two or more parameters to determine at least one of (i) whether a fibrinogen concentration in the test sample is below a threshold, or (ii) whether there is a therapeutic or pharmaceutical anticoagulant present in the test sample; and outputting, to a user interface, information based on the determination.Type: ApplicationFiled: December 22, 2022Publication date: October 5, 2023Inventors: Benjamin Horev, Ethan Schonbrun, Gert Blankenstein, Luisa Andruzzi, Anne Winkler, Jacqueline Scott
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Patent number: 11702696Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: GrantFiled: July 24, 2020Date of Patent: July 18, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
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Publication number: 20230167210Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.Type: ApplicationFiled: January 26, 2023Publication date: June 1, 2023Inventors: Geir FONNUM, Grete Irene MODAHL, Nini Hofsloekken KJUS, Astrid Evenroed MOLTEBERG, Diem Thuy Thi TRAN, Jo AASERUD, M. Talha GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
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Patent number: 11572427Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.Type: GrantFiled: February 2, 2021Date of Patent: February 7, 2023Assignees: LIFE TECHNOLOGIES CORPORATION, LIFE TECHNOLOGIES ASInventors: Geir Fonnum, Grete Irene Modahl, Nini Hofsloekken Kjus, Astrid Evenroed Molteberg, Diem Thuy Thi Tran, Jo Aaserud, M. Talha Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
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Publication number: 20220315995Abstract: The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: ApplicationFiled: February 3, 2022Publication date: October 6, 2022Inventors: Mong Sano MARMA, Luisa ANDRUZZI, Ben MCNALLY, Angela DELUCIA, Dona HEVRONI, Elizabeth CARPENTER, Magnus BESEV
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Patent number: 11421264Abstract: The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: GrantFiled: March 13, 2017Date of Patent: August 23, 2022Assignee: IsoPlexis CorporationInventors: Mong Sano Marma, Luisa Andruzzi, Ben McNally, Angela DeLucia, Dona Hevroni, Elizabeth Carpenter, Magnus Besev
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Publication number: 20210403985Abstract: The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods. In particular, the present invention contemplates the use of photoprotective mixture of compounds as imaging reagents to improve stability and storage of fluorescent compounds, including but not limited to, nucleotides with fluorescent labels.Type: ApplicationFiled: September 10, 2021Publication date: December 30, 2021Inventors: Luisa ANDRUZZI, Michel Georges PERBOST, Dona HEVRONI, Minakshi GUHA, Austin RICKER, Timothy PELLETIER
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Patent number: 11162129Abstract: The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods. In particular, the present invention contemplates the use of photoprotective mixture of compounds as imaging reagents to improve stability and storage of fluorescent compounds, including but not limited to, nucleotides with fluorescent labels.Type: GrantFiled: October 31, 2017Date of Patent: November 2, 2021Assignee: IsoPlexis CorporationInventors: Luisa Andruzzi, Michel Georges Perbost, Dona Hevroni, Minakshi Guha, Austin Ricker, Timothy Pelletier
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Publication number: 20210155726Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.Type: ApplicationFiled: February 2, 2021Publication date: May 27, 2021Inventors: Geir FONNUM, Grete Irene MODAHL, Nini Hofsloekken KJUS, Astrid Evenroed MOLTEBERG, Diem Thuy Thi TRAN, Jo AASERUD, M. Tahla GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
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Publication number: 20210078003Abstract: A flowcell device for a sequencing by synthesis instrument. The flowcell device has a fluid inlet configured to receive one or more liquid reagents, a fluid outlet configured to pass the one or more liquid reagents, and a channel extending between and fluidly connecting the fluid inlet and the fluid outlet. At least a portion of the channel comprises a reflective structure configured to retain a plurality of sequencing targets thereon. The reflective structure includes at least a metal oxide layer and a film having a first surface and a second surface opposed the first surface. The first surface of the film is disposed on the metal oxide layer and the second surface of the film is configured to receive a plurality of sequencing targets immobilized thereon.Type: ApplicationFiled: January 25, 2019Publication date: March 18, 2021Applicants: Qiagen GmbH, Qiagen Sciences, LLCInventors: Sebastian Koeber, Maximilian Focke, Luisa Andruzzi
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Patent number: 10947333Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.Type: GrantFiled: January 28, 2019Date of Patent: March 16, 2021Assignees: LIFE TECHNOLOGIES CORPORATION, LIFE TECHNOLOGIES ASInventors: Geir Fonnum, Grete Irene Modahl, Nini Hofsloekken Kjus, Astrid Evenroed Molteberg, Diem Thuy Thi Tran, Jo Aaserud, Muhammed Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
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Publication number: 20210002720Abstract: The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3?-O position capped by a disulfide-based 3?-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: ApplicationFiled: August 21, 2020Publication date: January 7, 2021Inventors: Luisa Andruzzi, Jimmy Adediran, Timothy Pelletier, Austin Ricker, Angela DeLucia, Ben McNally, Dona Hevroni, Mong Sano Marma, John Andrew Sheridan
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Patent number: 10844430Abstract: The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3?-O position capped by a disulfide-based 3?-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: GrantFiled: January 24, 2018Date of Patent: November 24, 2020Assignee: Qiagen Sciences, LLCInventors: Luisa Andruzzi, Jimmy Adediran, Timothy Pelletier, Austin Ricker, Angela DeLucia, Ben McNally, Dona Hevroni, Mong Sano Marma, John Andrew Sheridan
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Publication number: 20200354789Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: ApplicationFiled: July 24, 2020Publication date: November 12, 2020Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Steven M. MENCHEN, Alan BLANCHARD, Luisa ANDRUZZI, Shaheer KHAN, Dmitriy GREMYACHINSKIY, Alfred LUI, Craig STOLARCZYK, Tanya SOKOLSKY, Prasanna Krishnan THWAR
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Patent number: 10724094Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: GrantFiled: April 4, 2018Date of Patent: July 28, 2020Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer H. Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
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Patent number: D1014780Type: GrantFiled: April 15, 2022Date of Patent: February 13, 2024Assignee: Instrumentation Laboratory Co.Inventors: Ethan F. Schonbrun, Christopher Farren, Paul C. McCormack, Luisa Andruzzi