Patents by Inventor Luisa De Cola

Luisa De Cola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220169664
    Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.
    Type: Application
    Filed: January 31, 2022
    Publication date: June 2, 2022
    Inventors: Hans-Peter JOSEL, Tobias OELSCHLAEGEL, Giuseppe PRENCIPE, Luisa DE COLA, Elena LONGHI, Chien-Wei HSU
  • Patent number: 11267827
    Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: March 8, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hans-Peter Josel, Tobias Oelschlaegel, Giuseppe Prencipe, Luisa De Cola, Elena Longhi, Chien-Wei Hsu
  • Patent number: 10821082
    Abstract: The present invention relates to disintegratable core/shell silica particles encapsulating a bioactive macromolecule or bioactive macromolecule cluster in an active conformation, a method for producing the same, and uses thereof.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: November 3, 2020
    Assignee: UNIVERSITE DE STRASBOURG
    Inventors: Luisa De Cola, Eko Adi Prasetyanto, Alessandro Bertucci, Dedy Septiadi
  • Publication number: 20200277449
    Abstract: The invention relates to a hybrid hydrogel, in particular degradable or non-degradable, comprising a first hydrogel polymer of formula (I) in association with an alginate hydrogel polymer, and optionally organosilica particles in particular degradable or non-degradable nanoparticles, or porous silicon particles; pharmaceutical, veterinary and/or cosmetic compositions thereof; and uses thereof as a medicament. The invention notably relates to the use of such hybrid hydrogel in the treatment of fistulas and physiological leaks/leakages, notably in the gastrointestinal tract. The present invention finds applications in the therapeutic and diagnostic medical technical fields and also in cosmetic and veterinary technical fields.
    Type: Application
    Filed: September 17, 2018
    Publication date: September 3, 2020
    Inventors: Luisa DE COLA, Silvana PERRETTA, Giuseppe ALONCI, Pietro RIVA, Etienne PIANTANIDA, Ludovica GUERRIERO
  • Publication number: 20200138711
    Abstract: The invention relates to a hydrogel, in particular degradable or non degradable, comprising monomers of formula (I) and organosilica particles or porous silicon particles covalently bound thereto, optionally with non covalently bound organosilica and/or silicon particles mixed therewith, in particular degradable organosilica nanoparticles or core-shell nanocapsules; pharmaceutical, veterinary or cosmetic compositions thereof; and uses thereof as a medicament. The present invention finds applications in the therapeutic and diagnostic medical technical fields and also in cosmetic and veterinary technical fields.
    Type: Application
    Filed: January 17, 2018
    Publication date: May 7, 2020
    Inventors: Luisa DE COLA, Giuseppe ALONCI, Silvana PERRETTA, Pietro RIVA, Federica FIORINI
  • Publication number: 20200024292
    Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.
    Type: Application
    Filed: February 25, 2019
    Publication date: January 23, 2020
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Hans-Peter Josel, Tobias Oelschlaegel, Giuseppe Prencipe, Luisa De Cola, Elena Longhi, Chien-Wei Hsu
  • Publication number: 20200010623
    Abstract: The present invention relates to disintegratable mesoporous silica materials, a method for producing the same, and uses thereof.
    Type: Application
    Filed: August 1, 2019
    Publication date: January 9, 2020
    Inventors: Luisa DE COLA, Laura MAGGINI, Eko Adi PRASETYANTO
  • Patent number: 10450423
    Abstract: The present invention relates to disintegratable mesoporous silica materials, a method for producing the same, and uses thereof.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: October 22, 2019
    Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
    Inventors: Luisa De Cola, Laura Maggini, Eko Adi Prasetyanto
  • Patent number: 10227366
    Abstract: The present invention relates to novel bis-iridium-based Ir(III) complexes, labels manufactured using these complexes and a method for producing such complexes.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: March 12, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Robert Cysewski, Luisa de Cola, Jesus Miguel Fernandez Hernandez, Hans-Peter Josel, Elena Longhi, Gaston Hubertus Maria Vondenhoff
  • Publication number: 20190074657
    Abstract: The present invention relates to a random lasing photo-curable composition (1) for use as random lasing gain medium comprising:—laser dye molecules (11);—an optical glue (12) for the laser dye molecules to be suspended therein; wherein the optical glue is mercapto ester-based and comprises methacrylate and/or derivatives thereof. The present invention also relates to a random lasing system with a gain medium made of at least partially of random lasing photo-curable composition, and methods for manufacturing such random lasing system.
    Type: Application
    Filed: April 21, 2017
    Publication date: March 7, 2019
    Applicants: Université de Strasbourg, Centre National de la Recherche Scientifique
    Inventors: Luisa De Cola, Damiano Genovese, Valentin Barna
  • Patent number: 9879177
    Abstract: The present invention relates inter alia to a new class of heteroleptic metal complexes comprising condensed aromatic heterocyclic rings, their preparation and use.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: January 30, 2018
    Assignee: Merck Patent GmbH
    Inventors: Susanne Heun, Nils Koenen, Cheng-Han Yang, Luisa De Cola
  • Publication number: 20170119688
    Abstract: The present invention relates to disintegratable core/shell silica particles encapsulating a bioactive macromolecule or bioactive macromolecule cluster in an active conformation, a method for producing the same, and uses thereof.
    Type: Application
    Filed: June 12, 2015
    Publication date: May 4, 2017
    Applicant: Universite De Strasbourg
    Inventors: Luisa De Cola, Eko Adi Prasetyanto, Alessandro Bertucci, Dedy Septiadi
  • Patent number: 9499573
    Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: November 22, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Frank Bergmann, Robert Cysewski, Luisa de Cola, Sebastian Dziadek, Jesus Miguel Fernandez Hernandez, Hans-Peter Josel, Elena Longhi, Christoph Seidel
  • Publication number: 20160333145
    Abstract: The present invention relates to disintegratable mesoporous silica materials, a method for producing the same, and uses thereof.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 17, 2016
    Inventors: Luisa DE COLA, Laura MAGGINI, Eko Adi PRASETYANTO
  • Patent number: 9416150
    Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: August 16, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Frank Bergmann, Robert Cysewski, Luisa de Cola, Sebastian Dziadek, Jesus Miguel Fernandez Hernandez, Hans-Peter Josel, Christoph Seidel
  • Patent number: 9403859
    Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: August 2, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Frank Bergmann, Robert Cysewski, Luisa de Cola, Sebastian Dziadek, Jesus Miguel Fernandez Hernandez, Hans-Peter Josel, Christoph Seidel
  • Patent number: 9399654
    Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: July 26, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Frank Bergmann, Robert Cysewski, Luisa de Cola, Sebastian Dziadek, Jesus Miguel Fernandez Hernandez, Hans-Peter Josel, Christoph Seidel
  • Publication number: 20160145281
    Abstract: Novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, for example in the electrochemiluminescence based detection of an analyte.
    Type: Application
    Filed: September 28, 2015
    Publication date: May 26, 2016
    Inventors: Robert Cysewski, Luisa de Cola, Jesus Miguel Fernandez Hernandez, Hans-Peter Josel, Eloisa Lopez-Calle, Toralf Zarnt
  • Patent number: 9169434
    Abstract: This invention presents, firstly, the principle that simple and known emitter materials which are uncharged per se, as known, for example, from OLED technology, can be converted to a charged species by the introduction of a charged imidazolinium radical. This charged species can then be used in organic light-emitting electrochemical cells.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: October 27, 2015
    Assignee: OSRAM AG
    Inventors: Luisa De Cola, Claudia Bizzarri, David Hartmann, Sabine Szyszkowski, Wiebke Sarfert, Guenter Schmid
  • Publication number: 20150243910
    Abstract: Light emitting transition metal complexes comprising sub-units based on asymmetric tetradentate ligands comprising two different bidentate ligand units.
    Type: Application
    Filed: August 22, 2013
    Publication date: August 27, 2015
    Inventors: Luisa De Cola, Sebastian Duck, Robert Cysewski, Han Yang Cheng, Jean-Pierre Catinat