Abstract: The invention relates to a pressure-limiting device designed to be installed in a system comprising a first line (11) and a second line (12) that can comprise pressurised oil, as well as comprising a discharge and/or booster line (10). The limiting device is characterised in that it comprises means (131, 132, 133, 134) forming two valves, each associated with one of the two lines and adapted to open in the event of an overpressure above a pre-determined threshold on the associated line, so as to discharge the corresponding overpressure towards the discharge and/or booster line, said two valves comprising a common support stem (126) that operates in traction under the action of at least one spring defining a pressure corresponding to the pre-determined threshold. The invention also relates to a hydraulic assist system and to a vehicle comprising such a device.

Abstract: The present invention belongs to the field of pharmaceutical industry and relates to an amorphous solid dispersion comprising at least one polymer and dapagliflozin, to a pharmaceutical composition comprising said solid dispersion, to a process for the preparation thereof, and to the solid dispersion and pharmaceutical composition respectively obtainable by said process. Further, the present invention refers to an adsorbate comprising dapagliflozin and to a pharmaceutical composition comprising said adsorbate, as well as to a process for the preparation thereof. Finally, the present invention relates to the solid dispersion, the adsorbate or the pharmaceutical composition for use in the treatment of diseases related to hypoglycemia.

Abstract: The invention relates to a pressure-limiting device designed to be installed in a system comprising a first line (11) and a second line (12) that can comprise pressurised oil, as well as comprising a discharge and/or booster line (10). The limiting device is characterised in that it comprises means (131, 132, 133, 134) forming two valves, each associated with one of the two lines and adapted to open in the event of an overpressure above a pre-determined threshold on the associated line, so as to discharge the corresponding overpressure towards the discharge and/or booster line, said two valves comprising a common support stem (126) that operates in traction under the action of at least one spring defining a pressure corresponding to the pre-determined threshold. The invention also relates to a hydraulic assist system and to a vehicle comprising such a device.

Abstract: The invention relates to a flow control valve adapted for use as a flow-dividing and flow-combining valve in hydraulic devices, comprising: a valve body having a first longitudinally extending bore, an outer spool slidably positioned within the bore, the outer spool having an axially extending passageway, a pair of axially extending inner spools slidably positioned within the passageway, the valve body having a first port and a pair of second ports, the outer spool having at least a first opening communicating with the first port and with the passageway, and at least two pairs of second openings therethrough. At least one second opening of each pair is of non-constant longitudinal section narrowing from the outer face of the outer spool on at least a part of the thickness of the second opening, so that a lateral side of the second opening offers an obstacle where a part of the fluid flow entering the second opening crashes before entering the inner spool.

Abstract: The present invention belongs to the field of pharmaceutical industry and relates to an amorphous solid dispersion comprising at least one polymer and dapagliflozin, to a pharmaceutical composition comprising said solid dispersion, to a process for the preparation thereof, and to the solid dispersion and pharmaceutical composition respectively obtainable by said process. Further, the present invention refers to an adsorbate comprising dapagliflozin and to a pharmaceutical composition comprising said adsorbate, as well as to a process for the preparation thereof. Finally, the present invention relates to the solid dispersion, the adsorbate or the pharmaceutical composition for use in the treatment of diseases related to hypoglycemia.

Abstract: The invention relates to a flow control valve adapted for use as a flow-dividing and flow-combining valve in hydraulic devices, comprising: a valve body having a first longitudinally extending bore, an outer spool slidably positioned within the bore, the outer spool having an axially extending passageway, a pair of axially extending inner spools slidably positioned within the passageway, the valve body having a first port and a pair of second ports, the outer spool having at least a first opening communicating with the first port and with the passageway, and at least two pairs of second openings therethrough. At least one second opening of each pair is of non-constant longitudinal section narrowing from the outer face of the outer spool on at least a part of the thickness of the second opening, so that a lateral side of the second opening offers an obstacle where a part of the fluid flow entering the second opening crashes before entering the inner spool.

Abstract: The present invention relates to a pharmaceutical composition, preferably a pharmaceutical dosage form, comprising at least two separate compartments, wherein one compartment contains a composition comprising metformin or a pharmaceutically acceptable salt thereof and wherein another compartment contains a composition comprising sitagliptin. The present invention also relates to a process for preparing dosage forms comprising metformin or a pharmaceutically acceptable salt thereof and sitagliptin or a pharmaceutically acceptable salt thereof, the process comprising the steps of: a) providing one composition containing metformin or a pharmaceutically acceptable salt thereof and optionally also sitagliptin, b) providing a further composition containing sitagliptin or a pharmaceutically acceptable salt thereof and optionally also metformin, and c) combining the compositions to form compartments.

Abstract: The present invention relates to a pharmaceutical composition, preferably a pharmaceutical dosage form, comprising at least two separate compartments, wherein one compartment contains a composition comprising metformin or a pharmaceutically acceptable salt thereof and wherein another compartment contains a composition comprising sitagliptin. The present invention also relates to a process for preparing dosage forms comprising metformin or a pharmaceutically acceptable salt thereof and sitagliptin or a pharmaceutically acceptable salt thereof, the process comprising the steps of: a) providing one composition containing metformin or a pharmaceutically acceptable salt thereof and optionally also sitagliptin, b) providing a further composition containing sitagliptin or a pharmaceutically acceptable salt thereof and optionally also metformin, and c) combining the compositions to form compartments.

Abstract: The present invention relates to the use of certain aza-phenylalanine compounds of formula (I) wherein R1 denotes amino, alkylamino, dialkylamino, amidino, alkylamidino, N-hydroxyamidino, or N-alkoxyamidino, Y denotes sulfonyl or carbonyl and R2 and R4 independently represent various organic residues, in the treatment or prevention of cardiac arrhythmia and/or in treatment or prevention of diseases in association with ischemic heart conditions.