Patents by Inventor Lukas Balek

Lukas Balek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermostable FGF2 polypeptide, use thereof
    Patent number: 11746135
    Abstract: The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: September 5, 2023
    Assignees: Masarykova Univerzita, Enantis s.r.o.
    Inventors: Petr Dvorak, Pavel Krejci, Lukas Balek, Livia Eiselleova, Zaneta Konecna, Pavel Dvorak, David Bednar, Jan Brezovsky, Eva Sebestova, Radka Chaloupkova, Veronika Stepankova, Pavel Vanacek, Zbynek Prokop, Jiri Damborsky, Michaela Bosakova
  • Nanodiamonds as artificial proteins for regulation of a cell signalling system
    Patent number: 11744855
    Abstract: Nanodiamonds having a positive ?-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ?-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: September 5, 2023
    Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I, MASARYKOVA UNIVERZITA, FAKULTNI NEMOCNICE U SV, ANNY V BRNE
    Inventors: Petr Cigler, Lukas Balek, Jan Havlik, Pavel Krejci, Lukas Trantirek, Silvie Trantirkova
  • NANODIAMONDS AS ARTIFICIAL PROTEINS FOR REGULATION OF A CELL SIGNALLING SYSTEM
    Publication number: 20210015856
    Abstract: Nanodiamonds having a positive ?-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ?-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.
    Type: Application
    Filed: March 26, 2019
    Publication date: January 21, 2021
    Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., MASARYKOVA UNIVERZITA, FAKULTNI NEMOCNICE U SV. ANNY V BRNE
    Inventors: Petr CIGLER, Lukas BALEK, Jan HAVLIK, Pavel KREJCI, Lukas TRANTIREK, Silvie TRANTIRKOVA
  • Thermostable FGF2 Polypeptide, Use Thereof
    Publication number: 20200270320
    Abstract: The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
    Type: Application
    Filed: October 3, 2016
    Publication date: August 27, 2020
    Inventors: Petr Dvorak, Pavel Krejci, Lukas Balek, Livia Eiselleova, Zaneta Konecna, Pavel Dvorak, David Bednar, Jan Brezovsky, Eva Sebestova, Radka Chaloupkova, Veronika Stepankova, Pavel Vanacek, Zbynek Prokop, Jiri Damborsky, Michaela Bosakova