Abstract: Compounds represented by the structural formula (1) R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Abstract: Embodiments of the present disclosure present systems, devices, methods, and computer readable medium for contextual driver evaluation and feedback. The disclosed techniques allow for a graphical user interface to collect and annotate trip data from various sensors integrated in a mobile device for a user. The techniques presented describe the segmentation of the data into one or more populations and the identification of event and behavior features for each segment in order to evaluate a driver's ability. The techniques described present this information to the user through a graphical user interface that includes a driver score and coaching tips to improve the driver's future behavior.

Abstract: Compounds represented by the structural formula (1) R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Abstract: Embodiments of the present disclosure present systems, devices, methods, and computer readable medium for contextual driver evaluation. The disclosed techniques allow for collecting trip data from various sensors integrated in a mobile device for a user. The techniques include segregating the trip motion data into one or more segments associated with one or more populations with distinct features and characteristics. The trip data can be processed to identify event and behavior features that can be used to evaluate a driver's abilities in a contextually appropriate way. The information for a plurality of drivers can be compared to score the driver's ability amount a plurality of drivers.

Abstract: Embodiments of the present disclosure present systems, devices, methods, and computer readable medium for contextual driver evaluation. The disclosed techniques allow for collecting trip data from various sensors integrated in a mobile device for a user. The techniques include segregating the trip motion data into one or more segments associated with one or more populations with distinct features and characteristics. The trip data can be processed to identify event and behavior features that can be used to evaluate a driver's abilities in a contextually appropriate way. The information for a plurality of drivers can be compared to score the driver's ability amount a plurality of drivers.

Abstract: The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Abstract: The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Abstract: Methods, apparatuses and articles of manufacture for use in a mobile device to determine whether a dynamic user profile is to transition from a first state to a second state based, at least in part, on one or more sensed indicators. The dynamic user profile may be indicative of one or more current inferable user behavior contexts for a user co-located with the mobile device. The mobile device may transition a dynamic user profile from a first state to a second state, in response to a determination that the dynamic user profile is to transition from the first state to the second state, and operatively affect one or more functions performed, at least in part, by the mobile device based, at least in part, on the transition of the dynamic user profile to the second state.

Abstract: Methods, apparatuses and articles of manufacture for use in a mobile device to determine whether a dynamic user profile is to transition from a first state to a second state based, at least in part, on one or more sensed indicators. The dynamic user profile may be indicative of one or more current inferable user behavior contexts for a user co-located with the mobile device. The mobile device may transition a dynamic user profile from a first state to a second state, in response to a determination that the dynamic user profile is to transition from the first state to the second state, and operatively affect one or more functions performed, at least in part, by the mobile device based, at least in part, on the transition of the dynamic user profile to the second state.

Abstract: Methods, apparatuses and articles of manufacture for use in a mobile device to determine whether a dynamic user profile is to transition from a first state to a second state based, at least in part, on one or more sensed indicators. The dynamic user profile may be indicative of one or more current inferable user behavior contexts for a user co-located with the mobile device. The mobile device may transition a dynamic user profile from a first state to a second state, in response to a determination that the dynamic user profile is to transition from the first state to the second state, and operatively affect one or more functions performed, at least in part, by the mobile device based, at least in part, on the transition of the dynamic user profile to the second state.

Abstract: Disclosed are systems and methods to optimize a rules engine as a platform within a computing system. The computing system may identify a context of interest, such as environment or circumstance of the computing system or a user of the computing system. Based on the identified context of interest, the rules engine platform may selectively identify rules or sets of rules that are relevant to the context of interest. Accordingly, rules or sets of rules that are irrelevant to the context of interest may be omitted from evaluation. Therefore, resources of the computing system may not consumed in some embodiments by resolving conflicts between rules and evaluating rules that result in actions that are not suitable for the context of interest.

Abstract: Methods, systems, computer-readable media, and apparatuses for utilizing relationships between places of relevance are presented. In some embodiments, a mobile computing device may obtain information indicative of a micro-place of relevance visited by the mobile device at a first time. The information may be based on measurements taken by the mobile device at the first time. Further, the mobile device may derive an attribute of the visit to the micro-place of relevance based on the obtained information and a place model that associates micro-places of relevance with macro-places of relevance.

Abstract: Methods, systems, computer-readable media, and apparatuses for utilizing relationships between places of relevance are presented. In some embodiments, a mobile computing device may obtain information indicative of a micro-place of relevance visited by the mobile device at a first time. The information may be based on measurements taken by the mobile device at the first time. Further, the mobile device may derive an attribute of the visit to the micro-place of relevance based on the obtained information and a place model that associates micro-places of relevance with macro-places of relevance.

Abstract: Methods, apparatuses and articles of manufacture for use in a mobile device to determine whether a dynamic user profile is to transition from a first state to a second state based, at least in part, on one or more sensed indicators. The dynamic user profile may be indicative of one or more current inferable user behavior contexts for a user co-located with the mobile device. The mobile device may transition a dynamic user profile from a first state to a second state, in response to a determination that the dynamic user profile is to transition from the first state to the second state, and operatively affect one or more functions performed, at least in part, by the mobile device based, at least in part, on the transition of the dynamic user profile to the second state.

Abstract: Systems and methods are presented for constructing production plans to achieve one or more production goals, in which a diagnosis engine determines the production plant condition based on a previously executed plan, observations from the plant, and a plant model, and formulates a heuristic based on a diagnostic objective, and with a planner to performing a partial-plan search using the heuristic to construct the plans that will concurrently achieve at least one production goal and facilitate the diagnostic objective.

Abstract: Production control systems and methods are presented for estimation of production resource failure probabilities in which a set of four count values are maintained and updated for each resource including a first count value m11 indicating a number of plans where the resource m was used and failed, a second count value m10 indicating a number of plans where the resource m was used and succeeded, a third count value m01 indicating a number of plans where the resource m was not used and failed, and a fourth count value m00 indicating a number of plans where the resource m was not used and succeeded, and the current fault probability for each resource is estimated and stored for single or multiple, persistent or intermittent faults based on the corresponding count values.

Abstract: A control systems and methods are presented for controlling a production system, in which a model-based planner includes a formulation, such as a SAT formulation representing possible actions in the production, with a solver being used to provide a solution to the formulation based at least partially on production and diagnostic goals and the current plant condition, and a translation component translates the solution into a plan for execution in the plant.

Abstract: The present application relates to systems and methods for determining at least one target path from a start vertex to a goal vertex within a directed acyclic graph. The systems and methods use a target value search (MFTVS) of a directed acyclic graph. The MFTVS includes beginning with a start vertex as a current prefix and progressing through selected prefixes. The MFTVS further includes determining a selected prefix from successor prefixes of the current prefix according to a selection rule. The selection rule is one of selecting the successor prefix having a highest path value and selecting the successor prefix having a lowest path value. The MFTVS further includes setting the current prefix to the selected prefix until a frontier of a blind spot is encountered. The frontier of the blind spot is defined by an evaluation function.

Abstract: A control systems and methods are presented for controlling a production system, in which a model-based planner includes a formulation, such as a SAT formulation representing possible actions in the production, with a solver being used to provide a solution to the formulation based at least partially on production and diagnostic goals and the current plant condition, and a translation component translates the solution into a plan for execution in the plant.