Abstract: A system, method and program product for enhancing radiographic images. A disclosed method includes: determining a sensitivity function of a computed radiography (CR) plate from at least one blank plate image, wherein the sensitivity function is a measure of noise caused by a phosphor grain pattern in the CR plate; inputting a specimen image captured using the CR plate; generating a blank plate-to-specimen (B2S) alignment map that provides a correspondence between pixel locations in the sensitivity function and the specimen image; applying a sensitivity function correction algorithm to the specimen image based on the B2S alignment map, wherein the sensitivity function correction algorithm is derived from the sensitivity function; and outputting an enhanced specimen image. A second disclosed method includes merging independent images of the same specimen to reduce noise. A third disclosed method includes a deconvolution algorithm for improving spatial resolving power.