Patents by Inventor Lukas Krejcik

Lukas Krejcik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable polymorph of the salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-?]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-anime with L-tartaric acid
    Patent number: 9862723
    Abstract: A stable polymorph (Form Z1) of the salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [152,4]triazolo[4,3-?]pyrazin-7(8H)-yl]-1-(2s4,5-trifluorophenyl)butan-2-amine (sitagliptin) with L-tartaric acid, of formula 1, which is a very suitable form of the active pharmaceutical ingredient of medicinal products intended especially for treatment of diabetes type 2. A method of preparation of the stable polymorph (Form Z1) of the salt of sitagliptin with L-tartaric acid, as well as its use for the preparation of a pharmaceutical composition.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: January 9, 2018
    Assignee: Zentiva k.s.
    Inventors: Jindrich Richter, Petr Lehnert, Kamal Jarrah, Ondrej Dammer, Lukas Krejcik
  • A STABLE POLYMORPH OF THE SALT OF (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE WITH L-TARTARIC ACID
    Publication number: 20160251360
    Abstract: A stable polymorph (Form Z1) of the salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [152,4]triazolo[4,3-?]pyrazin-7(8H)-yl]-1-(2s4,5-trifluorophenyl)butan-2-amine (sitagliptin) with L-tartaric acid, of formula 1, which is a very suitable form of the active pharmaceutical ingredient of medicinal products intended especially for treatment of diabetes type 2. A method of preparation of the stable polymorph (Form Z1) of the salt of sitagliptin with L-tartaric acid, as well as its use for the preparation of a pharmaceutical composition.
    Type: Application
    Filed: October 30, 2014
    Publication date: September 1, 2016
    Inventors: Jindrich RICHTER, Petr LEHNERT, Kamal JARRAH, Ondrej DAMMER, Lukas KREJCIK
  • Salts of desvenlafaxine and a method of their preparation
    Patent number: 8779005
    Abstract: The invention deals with new salts of the desvenlafaxine base of formula (I) with oxalic acid, the new salts being the hydrogen oxalate of formula (II) in the proportion of desvenlafaxine:oxalic acid of 1:1 and hemioxalate of formula (III) in the proportion of desvenlafaxine:oxalic acid of 2:1.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: July 15, 2014
    Assignee: Zentiva k.s.
    Inventors: Ludek Ridvan, Petr Hruby, Stanislav Radl, Hana Brusova, Lukas Krejcik, Tomas Pekarek, Natalia Csokova, Anna Zerzanova
  • NEW SALTS OF DESVENLAFAXINE AND A METHOD OF THEIR PREPARATION
    Publication number: 20120041227
    Abstract: The invention deals with new salts of the desvenlafaxine base of formula (I) with oxalic acid, the new salts being the hydrogen oxalate of formula (II) in the proportion of desvenlafaxine:oxalic acid of 1:1 and hemioxalate of formula (III) in the proportion of desvenlafaxine:oxalic acid of 2:1.
    Type: Application
    Filed: February 3, 2010
    Publication date: February 16, 2012
    Inventors: Ludek Ridvan, Petr Hruby, Stanislav Radl, Hana Brusova, Lukas Krejcik, Tomas Pekarek, Natalia Csokova, Anna Zerzanova