Abstract: A piezoresistive pressure sensor for measuring the pressure of a medium in an environment includes a housing defining an interior, a base body disposed in the interior and connected to the housing and defining a diaphragm, and a measuring unit with a piezoresistive element disposed in the interior so as to detect a deflection of the diaphragm. The diaphragm confines a blind hole of the base body and an opening through the housing is arranged to communicate with the blind hole when the piezoresistive pressure sensor is exposed to the medium so as to deflect the diaphragm. A material bonding connection connects the base body directly to the housing in a mechanically tight manner while exhibiting a melting temperature greater than or equal to 250° C. An electrical conductor taps the piezoresistive element's change in resistance as electrical voltage and discharges the voltage into the environment.

Abstract: The disclosure relates to methods, treatment regimens, uses, kits and therapies for treating hidradenitis suppurativa, by employing CD40 antagonists, such as anti-CD40 antibodies.

Abstract: Described herein are multispecific antibodies targeting IL-13 and IL-18. The multispecific antibodies can be antagonistic and/or therapeutic antibodies targeting IL-13 and IL-18. Also described herein are methods of making said multispecific antibodies, methods of inhibiting IL-13 and IL-18 simultaneously with said multispecific antibodies, and methods of treating an IL-13/IL-18 mediated disorder, such as atopic dermatitis, by administering a multispecific antibody described herein.

Abstract: The disclosure relates to methods, treatment regimens, uses, kits and therapies for treating hidradenitis suppurativa, by employing CD40 antagonists, such as anti-CD40 antibodies.

Abstract: Methods are disclosed for the early non-invasive diagnosing of acute rejection (AR) in a transplanted subject, monitoring AR in a transplanted subject at risk of developing AR, preventing, inhibiting, reducing or treating AR in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of AR, based on genes which are differentially expressed in peripheral blood or transplant biopsy tissues, before full clinical manifestation of AR is detected in the transplanted subject.