Abstract: A device for proposing an insulin dosage for a diabetes patient, wherein the device comprises an input interface configured for receiving patient glucose level data indicative of glucose level information of the patient, a processor configured for determining the insulin dosage in an interactive time-dependent manner based on applying the received patient glucose level data to at least only predefined insulin dosage determining criterion, and an output interface configured for outputting a result of the determining as a proposal for the insulin dosage indicative of doses and assigned times of the day according to which insulin is to be administered to the diabetes patient.

Abstract: A membrane-free perfusion catheter comprising an exchange surface having a filament structure, a delivery unit for delivery of perfusion fluid to a lumen of the filament structure in a manner to allow for an exchange of substances between a medium surrounding the lumen and the perfusion fluid via the filament structure, and a drain unit for draining the medium surrounding the exchange surface and/or for draining the perfusion fluid delivered to the lumen of the filament structure after the exchange of substances between the medium surrounding the lumen and the perfusion fluid via the filament structure.

Abstract: A device for monitoring a parameter of a fluidic sample by microdialysis, the device comprising a permeable membrane, wherein the permeable membrane has a first surface to be brought in contact with the fluidic sample to traverse the permeable membrane (300), wherein the permeable membrane has a second surface to be brought in contact with a dialysis fluid, and wherein the first surface is smoother than the second surface.

Abstract: A device for delivery of glucose-regulating medication, particularly insulin, depending on the measured tissue glucose concentration, having a sensor for measuring the glucose concentration in tissue fluid, possibly a unit for removing fluid from subcutaneous tissue, as well as a container for the glucose-regulating medications, having a unit for subcutaneous delivery of the glucose-regulating medications, and having a unit connected to the glucose sensor for regulating the quantity of the glucose-regulating medication to be delivered depending on the measured tissue glucose concentrations. The device simulates the function of the natural pancreas and is constructed small and compact.

Abstract: A membrane-free perfusion catheter comprising an exchange surface having a filament structure, a delivery unit for delivery of perfusion fluid to a lumen of the filament structure in a manner to allow for an exchange of substances between a medium surrounding the lumen and the perfusion fluid via the filament structure, and a drain unit for draining the medium surrounding the exchange surface and/or for draining the perfusion fluid delivered to the lumen of the filament structure after the exchange of substances between the medium surrounding the lumen and the perfusion fluid via the filament structure.

Abstract: A device for monitoring a parameter of a fluidic sample by microdialysis, the device comprising a permeable membrane, wherein the permeable membrane has a first surface to be brought in contact with the fluidic sample to traverse the permeable membrane (300), wherein the permeable membrane has a second surface to be brought in contact with a dialysis fluid, and wherein the first surface is smoother than the second surface.

Abstract: A catheter (100) for insertion into tissue of a physiological object, the catheter comprising a tube (101) made of a flexible biocompatible impermeable material, and an oblong slit (102) formed in a wall of the tube and extending along a longitudinal axis (103) of the tube, and a delivery unit for delivery of perfusion fluid to a lumen (104) of the structure in a manner to allow for an exchange of substances between the tissue and the perfusion fluid via the oblong slit.

Abstract: A device (10) for delivery of glucose-regulating medication depending on the measured tissue glucose concentration, having a sensor (7) for measuring the glucose concentration in the tissue fluid, possibly a unit (1) for removing fluid from subcutaneous tissue (11), as well as a container (14) for the medications, having a unit (23) for subcutaneous delivery of the glucose-regulating medications, and having a unit (12) connected to the glucose sensor (7) for regulating the delivery of the glucose-regulating medication depending on the measured tissue glucose concentrations. To provide a device (10) simulating the function of the natural pancreas and being compact, the sensor (7) for measuring the tissue glucose concentration or the unit (1) for removing the tissue fluid is combined with the delivery unit (23), particularly in a shared catheter (25), so that the measurement of the tissue glucose concentration is essentially performed at the location of the delivery of the glucose-regulating medication.

Abstract: The invention relates to a method for measuring the concentration of substances in living organisms using microdialysis, whereby bodily fluid is mixed with a perfusate and passed through a membrane and a substance value is determined for the bodily fluid with the aid of a sensor unit. According to the invention, to allow for the limited transport through the membrane, so that the measured substance value differs from the actual substance value in the organism, a reference substance present in said organism with a known value is also measured after passing through the membrane and mixing with the perfusate and the actual substance value is determined, based on the quotient from the known reference substance value divided by the measured reference substance value, multiplied by the measured substance value.

Abstract: The invention relates to a method for measuring the concentration of substances in living organisms using microdialysis, whereby bodily fluid is mixed with a perfusate and passed through a membrane and a substance value is determined for the bodily fluid with the aid of a sensor unit. According to the invention, to allow for the limited transport through the membrane, so that the measured substance value differs from the actual substance value in the organism, a reference substance present in said organism with a known value is also measured after passing through the membrane and mixing with the perfusate and the actual substance value is determined, based on the quotient from the known reference substance value divided by the measured reference substance value, multiplied by the measured substance value.

Abstract: In a device (10) for in-vivo measurements of quantities in living organisms that comprises a catheter-like tube (11) receiving in a removable manner a setting needle (14) provided for inserting the tube in the organism, with at least one aperture (12) being provided in the wall of the tube (11); and a sensor (18) for detecting the quantity to be measured in the interior of the tube; the sensor (18) is mounted on a separate oblong carrier (17) whose cross sectional dimensions are smaller than those of the interior of the tube. After the setting needle (14) has been pulled out of the tube (11), the sensor can be inserted in said tube (11).