Abstract: The present application relates to processes for the preparation of intermediates useful in the manufacture of oseltamivir and the H3PO4 salt of oseltamivir, Tamiflu®. The application further relates to novel intermediate and compounds and oseltamivir analogs and to pharmaceutical compositions comprising said analog compounds. The application further relates to a method of using the novel analogs of oseltamivir to treat or prevent influenza.

Abstract: The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds.

Abstract: The present invention provides a method for the N-demethylation and N-functionalization of an N-methylated heterocycle such as a morphine alkaloid or tropane alkaloid. The method comprises reacting the heterocycle with an functionalization agent in the presence of a transition metal catalyst in air or in the presence of an oxidant.

Abstract: A utensil for containing foodstuffs, applicable to cooking in a microwave oven, including a receptacle made of an elastomer material with an access opening and a cover for covering the access opening. The receptacle is formed by one or more walls including a bottom wall in elongated channel shape and opening edges defining the access opening at a height greater than the bottom. The bottom wall includes reinforcing ribs projecting outwardly from an outer surface thereof and providing supports leaving most of the outer surface of the bottom wall exposed to the surrounding atmosphere when the receptacle is on a support surface. The bottom wall is connected at its ends to end walls determining respective end opening edges configured to support lids.