Patents by Inventor Lukas Wick
Lukas Wick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230265480Abstract: A method is for the detection of presence or absence, quantification, and identification of target microorganisms, such as bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence. The method include providing a medium with one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the dioxetane compound emits light, and detecting the emitted light.Type: ApplicationFiled: March 15, 2023Publication date: August 24, 2023Inventors: Doron SHABAT, Michal Eli ROTH-KONFORTI, Nir HANANYA, Ori GREEN, Urs SPITZ, Lukas WICK, Julian IHSSEN, Raffael VORBERG, Riccardo CRIBIU, Zuzana BABJAKOVÀ, Chunyan YAO
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Patent number: 11649475Abstract: Dioxetane compounds represented by Formula I below, and methods of using the dioxetane compounds in the detection of presence or absence, quantification, and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, and fungi by means of chemiluminescence.Type: GrantFiled: May 24, 2019Date of Patent: May 16, 2023Assignees: Ramot at Tel-Aviv University Ltd., NEMIS Technologies AGInventors: Doron Shabat, Michal Eli Roth-Konforti, Nir Hananya, Ori Green, Urs Spitz, Lukas Wick, Julian Ihssen, Raffael Vorberg, Riccardo Cribiu, Zuzana Babjakovà, Chunyan Yao
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Publication number: 20230107185Abstract: The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.Type: ApplicationFiled: August 18, 2022Publication date: April 6, 2023Inventors: Urs SPITZ, Günter SCHABERT, Aysel SOYDEMIR, Lukas WICK
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Patent number: 11447514Abstract: The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.Type: GrantFiled: May 17, 2019Date of Patent: September 20, 2022Assignee: Roche Diagnostics Operations, Inc.Inventors: Urs Spitz, Günter Schabert, Aysel Soydemir, Lukas Wick
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Patent number: 11149756Abstract: In order to carry out largely automated parameterisation of the closed-loop control parameters for closed-loop control of a hydraulic system comprising a servo drive, a method and a device for determining the closed-loop parameters of a closed-loop control unit of the hydraulic system are specified, wherein an actual system pressure of a hydraulic consumer of the hydraulic system is closed-loop controlled by means of a predefined set point rotational speed of a servo drive, wherein an actual rotational speed of the servo drive follows the predefined set point rotational speed, wherein an excitation signal is applied to the setpoint rotational speed, and the actual system pressure which is set here is measured, the dynamics of the hydraulic system are acquired from the actual rotational speed and/or the setpoint rotational speed and the actual system pressure, and the closed-loop control parameters are calculated from the acquired dynamics.Type: GrantFiled: March 20, 2018Date of Patent: October 19, 2021Assignee: B&R INDUSTRIAL AUTOMATION GMBHInventors: Kurt Zehetleitner, Lukas Wick, Leopold Griessler
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Publication number: 20210214766Abstract: Dioxetane compounds can be used in the detection of presence or absence, quantification and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence and to corresponding methods. A method for the detection of a target analyte, a target microorganism or a target metabolite includes providing a medium including one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the compound emits light, and detecting the emitted light.Type: ApplicationFiled: May 24, 2019Publication date: July 15, 2021Inventors: Doron SHABAT, Michal Eli ROTH-KONFORTI, Nir HANANYA, Ori GREEN, Urs SPITZ, Lukas WICK, Julian IHSSEN, Raffael VORBERG, Riccardo CRIBIU, Zuzana BABJAKOVÀ, Chunyan YAO
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Publication number: 20210206793Abstract: The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.Type: ApplicationFiled: May 17, 2019Publication date: July 8, 2021Applicant: Roche Diagnostics Operations, Inc.Inventors: Urs SPITZ, Günter SCHABERT, Aysel SOYDEMIR, Lukas WICK
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Publication number: 20200096013Abstract: In order to carry out largely automated parameterisation of the closed-loop control parameters for closed-loop control of a hydraulic system comprising a servo drive, a method and a device for determining the closed-loop parameters of a closed-loop control unit of the hydraulic system are specified, wherein an actual system pressure of a hydraulic consumer of the hydraulic system is closed-loop controlled by means of a predefined set point rotational speed of a servo drive, wherein an actual rotational speed of the servo drive follows the predefined set point rotational speed, wherein an excitation signal is applied to the setpoint rotational speed, and the actual system pressure which is set here is measured, the dynamics of the hydraulic system are acquired from the actual rotational speed and/or the setpoint rotational speed and the actual system pressure, and the closed-loop control parameters are calculated from the acquired dynamics.Type: ApplicationFiled: March 20, 2018Publication date: March 26, 2020Applicant: B&R INDUSTRIAL AUTOMATION GMBHInventors: Kurt ZEHETLEITNER, Lukas WICK, Leopold GRIESSLER
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Patent number: 9157917Abstract: A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.Type: GrantFiled: November 4, 2011Date of Patent: October 13, 2015Assignee: Biosynth AGInventors: Lukas Wick, Urs Spitz, Christophe Weymuth, Günter Schabert, Thomas Mayer, Alexander Bayer
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Patent number: 9127303Abstract: A method for detection of beta-D-glucuronidase activity in a sample that comprises the steps of (i) providing a glucuronic acid ester compound of the general formula (I) wherein R1 is a C1-4 alkyl group, OR2 is a dye moiety, which is liberated after cleavage of the glycosidic bond; (ii) contacting said glucuronic acid ester compound with a material of said sample exhibiting hydrolytic activity towards glucuronic acid esters, thereby removing R1 and thus forming a sample containing an indicator compound suitable for the detection and/or measurement of beta-D-glucuronidase activity, and (iii) using said indicator to perform an assay requiring detection or measurement of beta-D-glucuronidase activity.Type: GrantFiled: June 8, 2012Date of Patent: September 8, 2015Assignee: Biosynth AGInventors: Urs Spitz, Lukas Wick, Gunter Schabert
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Patent number: 8940909Abstract: A novel indicator platform comprises a plurality of 1H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.Type: GrantFiled: May 6, 2010Date of Patent: January 27, 2015Assignee: Biosynth AGInventors: Urs Spitz, Lukas Wick, Alexander Bayer, Christophe Weymuth, Günter Schabert
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Publication number: 20140377783Abstract: A novel type of dye systems comprises a selection of 10H-indolo[1,2-a]indole compounds (henceforth abbreviated as IO compounds) and (5H,7H)-indolo[1,2-a]quinoline compounds (henceforth abbreviated as IQ compounds) showing a solvatochromic effect and exhibiting strong fluorescence in a variety of materials such as polypropylene, polyethylene, oils, various solvents, emulsions. Also disclosed are various methods how the IO/IQ compounds can be administered, especially how they can be produced and administered in situ from a precursor, responding to external stimuli such as enzyme activity, temperature and so forth. The response of a precursor to external stimuli can also be used to determine the presence or absence of such stimuli.Type: ApplicationFiled: November 4, 2011Publication date: December 25, 2014Inventors: Lukas Wick, Urs Spitz, Christophe Weymuth, Günter Schabert, Thomas Mayer, Alexander Bayer
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Publication number: 20140212905Abstract: A method for detection of beta-D-glucuronidase activity in a sample that comprises the steps of (i) providing a glucuronic acid ester compound of the general formula (I) wherein R1 is a C1-4 alkyl group, OR2 is a dye moiety, which is liberated after cleavage of the glycosidic bond; (ii) contacting said glucuronic acid ester compound with a material of said sample exhibiting hydrolytic activity towards glucuronic acid esters, thereby removing R1 and thus forming a sample containing an indicator compound suitable for the detection and/or measurement of beta-D-glucuronidase activity, and (iii) using said indicator to perform an assay requiring detection or measurement of beta-D-glucuronidase activity.Type: ApplicationFiled: June 8, 2012Publication date: July 31, 2014Inventors: Urs Spitz, Lukas Wick, Günter Schabert
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Publication number: 20120058503Abstract: A novel indicator platform comprises a plurality of 1H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.Type: ApplicationFiled: May 6, 2010Publication date: March 8, 2012Applicant: Biosynth AGInventors: Urs Spitz, Lukas Wick, Alexander Bayer, Christophe Weymuth, Günter Schabert
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Publication number: 20100291591Abstract: Plating media contains enzyme substrates (ES) used to detect enzyme activity associated with a target organism and that include a binding motif (BM) that serves to bind detectable enzymes (DE) (also called marker enzymes in this disclosure). A signalogenic substructure (SG) produces detectable signals and an enzyme labile group (ELG) is labile to the action of a marker enzyme and it typically includes the binding motif. The enzyme labile group links to the signalogenic substructure via a labile bond (LB) which is cleaved by the action of the marker enzyme separating the signalogenic substructure and the enzyme labile group. In some embodiments a linker is inserted between the signalogenic substructure and the enzyme labile group. Presence of the enzyme and thus the organism is detected by presence of a fluorogenic, precipitate that can be detected in single colonies.Type: ApplicationFiled: November 4, 2008Publication date: November 18, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Lukas Wick, Guenter Schabert, Urs Spitz