Patents by Inventor Lukasz Joachimiak

Lukasz Joachimiak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Pyrrolotriazines
    Publication number: 20240150362
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 9, 2024
    Inventors: Jacek Chrzanowski, Anna Gzik, Joanna Brzezinska, Robert Koralewski, Lukasz Joachimiak, Karolina Rozga, Szymon Kapuscinski, Bartlomiej Borek, Mateusz Urban, Sylwia Ciastek-Iskrzycka, Julita Nowicka, Kamil Lisiecki, Roman Blaszczyk, Adam Golebiowski, Jacek Olczak
  • DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230219973
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.
    Type: Application
    Filed: December 22, 2022
    Publication date: July 13, 2023
    Inventors: Jacek CHRZANOWSKI, Julita NOWICKA, Lukasz JOACHIMIAK, Robert KORALEWSKI, Sylwia OLEJNICZAK, Marzena MAZUR, BartlomieJ BOREK, Anna GZIK, Krzysztof MATYSZEWSKI, Sylwia CIASTEK-ISKRZYCKA, Piotr NIEDZIEJKO, Angelika MUCHOWICZ, Zbigniew ZASLONA, Roman BLASZCZYK, Jacek OLCZAK, Adam GOLEBIOWSKI
  • Substituted amino triazoles useful as chitinase inhibitors
    Patent number: 11638707
    Abstract: Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: May 2, 2023
    Assignee: Molecure S.A.
    Inventors: Marzena Mazur, Gleb Andryianau, Lukasz Joachimiak, Wojciech Czestkowski, Michal Kowalski, Piotr Niedziejko, Sylwia Olejniczak, Krzysztof Matyszewski, Robert Koralewski, Jacek Olczak, Adam Golebiowski, Agnieszka Bartoszewicz
  • TAU PEPTIDE ANTIGENS AND ANTIBODIES BINDING THERETO FOR THE TREATMENT OF TAUOPATHIES
    Publication number: 20220273779
    Abstract: The disclosure provides methods and compositions for treating and diagnosing tauopathies. More specifically, the disclosure relates to the identification of epitopes on tau and their use as vaccines or as reagents to generate monoclonal antibodies that can be used for both diagnosis and treatment of tau-related diseases.
    Type: Application
    Filed: November 18, 2019
    Publication date: September 1, 2022
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Marc I. DIAMOND, Kenneth DROMBOSKY, Dailu CHEN, Victor MANON, Xiaohua LIU, Hamid MIRZAEI, Jaime VAQUER-ALICEA, Hilda MIRBAHA, Lukasz A. JOACHIMIAK
  • SUBSTITUTED AMINO TRIAZOLES USEFUL AS CHITINASE INHIBITORS
    Publication number: 20210015822
    Abstract: Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
    Type: Application
    Filed: July 15, 2020
    Publication date: January 21, 2021
    Inventors: Marzena Mazur, Gleb Andryianau, Lukasz Joachimiak, Wojciech Czestkowski, Michal L. Kowalski, Piotr Niedziejko, Sylwia Olejniczak, Krzysztof Matyszewski, Robert Koralewski, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz
  • METHODS, SYSTEMS, AND REAGENTS FOR DIRECT RNA SEQUENCING
    Publication number: 20170159033
    Abstract: Provided are compositions comprising recombinant polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for sequencing RNA or RNA/DNA templates. Polymerases that topologically encircle the template nucleic acid are provided. Also provided are methods of using such polymerases to make a DNA or to sequence a template comprising RNA.
    Type: Application
    Filed: October 26, 2016
    Publication date: June 8, 2017
    Inventors: Satwik Kamtekar, Jeremiah Hanes, Erik Miller, Lukasz Joachimiak