Abstract: The present disclosure describes various aspects of devices, and methods of making and using the devices, for in vivo sensing of luminal concentration of a compound of interest within a gastrointestinal (GI) tract of a subject. An ingestible housing has an outer profile to pass through the subject's GI tract. A battery and a communication module are contained inside of the housing. A sensor is disposed on an outer surface of the housing. The sensor comprises one or more electrodes configured to contact luminal contacts of the subject's GI tract while the sensor is in motion traversing through the subject's GI tract. A plurality of electrical signals is controlled, and comprises attributes relating to a property of the compound of interest. A continuous output signal is received from the sensor, indicating an extent to which the compound of interest is present in the luminal contents.

Abstract: The present disclosure describes various aspects of various devices, and methods of making and using the devices, for measuring bioimpedance of tissues within a patient's body, such as GI tract tissue. The devices entail using various implementations of capsules or other housings that allow for ingestion or other insertion into a body of the device, equipped with microfabricated sensors and embedded circuitry enabling wireless communication. Among other benefits, this approach addresses a gap in conventional GI tract monitoring devices and methods to non-invasively access the small intestine and directly measure the inflammatory state of intestinal tissue, including ischemia, edema, and mucosal abnormalities.

Abstract: This disclosure sets forth various systems and methods for deploying anchored medical devices within a human or animal. The medical devices may deliver payloads, such as various sensors, electrodes, transmitters, cameras, electrical or other interventional devices, drugs or therapeutics. The devices may have one or more anchors, which attach the device to an anatomy of interest. This allows for methods and processes to be performed over periods of time, such as extended delivery of a therapy or real time sensing of characteristics inside a body, which the device remains within a given location.