Patents by Inventor Luke Alphey
Luke Alphey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240093230Abstract: The invention provides a splice control module for sex-specific splicing and expression of a gene of interest. In certain embodiments, a dsx-based splice control module is used to express a lethal gene in an insect that is spliced in a sex-specific manner to impart lethality to female insects but not male insects.Type: ApplicationFiled: October 18, 2023Publication date: March 21, 2024Applicant: Oxitec Ltd.Inventors: Luke ALPHEY, Tarig DAFA'ALLA, Amandine COLLADO, Simon WARNER, Kelly MATZEN, Sian SPINNER
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Publication number: 20240016132Abstract: Two or more conditional, dominant, lethal gene expression systems provide high levels of penetrance in insects. Lethality is induced at an earlier stage of development and the risk of biochemical resistance is reduced, as compared to a single insect conditional, dominant, lethal gene expression system. The invention is useful for the control of insect populations.Type: ApplicationFiled: July 14, 2023Publication date: January 18, 2024Applicant: Oxitec LimitedInventors: Martha Koukidou, Luke Alphey, Simon Warner
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Patent number: 11827876Abstract: The invention provides a splice control module for sex-specific splicing and expression of a gene of interest. In certain embodiments, a dsx-based splice control module is used to express a lethal gene in an insect that is spliced in a sex-specific manner to impart lethality to female insects but not male insects.Type: GrantFiled: August 9, 2017Date of Patent: November 28, 2023Assignee: OXITEC LTD.Inventors: Luke Alphey, Tarig Dafa'alla, Amandine Collado, Simon Warner, Kelly Matzen, Sian Spinner
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Patent number: 11737436Abstract: Two or more conditional, dominant, lethal gene expression systems provide high levels of penetrance in insects. Lethality is induced at an earlier stage of development and the risk of biochemical resistance is reduced, as compared to a single insect conditional, dominant, lethal gene expression system. The invention is useful for the control of insect populations.Type: GrantFiled: August 19, 2020Date of Patent: August 29, 2023Assignee: Oxitec LimitedInventors: Martha Koukidou, Luke Alphey, Simon Warner
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Publication number: 20210137083Abstract: Two or more conditional, dominant, lethal gene expression systems provide high levels of penetrance in insects. Lethality is induced at an earlier stage of development and the risk of biochemical resistance is reduced, as compared to a single insect conditional, dominant, lethal gene expression system. The invention is useful for the control of insect populations.Type: ApplicationFiled: August 19, 2020Publication date: May 13, 2021Inventors: Martha Koukidou, Luke Alphey, Simon Warner
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Patent number: 10941416Abstract: A polynucleotide expression system is provided that is capable of alternative splicing of RNA transcripts of a polynucleotide sequence to be expressed in an organism.Type: GrantFiled: May 1, 2018Date of Patent: March 9, 2021Assignee: Oxitec LimitedInventor: Luke Alphey
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Publication number: 20200407748Abstract: The invention provides a splice control module for sex-specific splicing and expression of a gene of interest. In certain embodiments, a dsx-based splice control module is used to express a lethal gene in an insect that is spliced in a sex-specific manner to impart lethality to female insects but not male insects.Type: ApplicationFiled: August 9, 2017Publication date: December 31, 2020Applicant: OXITEC LTD.Inventors: Luke ALPHEY, Tarig DAFA'ALLA, Amandine COLLADO, Simon WARNER, Kelly MATZEN, Sian SPINNER
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Patent number: 10844402Abstract: A gene expression system is provided. The system comprises at least one coding sequence to be expressed in an organism, and at least one promoter operably linked thereto. It further comprises at least one splice control sequence which, in cooperation with a spliceosome, mediates alternative splicing of RNA transcripts of the coding sequence. The mediation of alternative splicing is in a sex-specific, stage-specific, germline-specific and tissue-specific manner.Type: GrantFiled: July 13, 2018Date of Patent: November 24, 2020Assignee: Oxitec LimitedInventor: Luke Alphey
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Patent number: 10426147Abstract: Provided is a gene expression system, suitable for expression in an insect, comprising an insect muscle actin promoter operably linked to a marker gene, which overcomes or ameliorates one or more of: cost of rearing; amount of handling; errors in identification due to human error or loss of marker by the insect; and health concerns related to the effects of marker powders on workers in mass rearing facilities.Type: GrantFiled: June 23, 2017Date of Patent: October 1, 2019Assignee: Oxitec LimitedInventors: Martha Koukidou, Sarah Scaife, Luke Alphey
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Publication number: 20180312870Abstract: A gene expression system is provided. The system comprises at least one coding sequence to be expressed in an organism, and at least one promoter operably linked thereto. It further comprises at least one splice control sequence which, in cooperation with a spliceosome, mediates alternative splicing of RNA transcripts of the coding sequence. The mediation of alternative splicing is in a sex-specific, stage-specific, germline-specific and tissue-specific manner.Type: ApplicationFiled: July 13, 2018Publication date: November 1, 2018Inventor: Luke Alphey
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Publication number: 20180251785Abstract: A polynucleotide expression system is provided that is capable of alternative splicing of RNA transcripts of a polynucleotide sequence to be expressed in an organism.Type: ApplicationFiled: May 1, 2018Publication date: September 6, 2018Applicant: Oxitec LimitedInventor: Luke ALPHEY
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Patent number: 10059961Abstract: A gene expression system is provided. The system comprises at least one coding sequence to be expressed in an organism, and at least one promoter operably linked thereto. It further comprises at least one splice control sequence which, in cooperation with a spliceosome, mediates alternative splicing of RNA transcripts of the coding sequence. The mediation of alternative splicing is in a sex-specific, stage-specific, germline-specific and tissue-specific manner.Type: GrantFiled: August 28, 2015Date of Patent: August 28, 2018Assignee: Oxitec LimitedInventor: Luke Alphey
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Patent number: 9970025Abstract: A polynucleotide expression system is provided that is capable of alternative splicing of RNA transcripts of a polynucleotide sequence to be expressed in an organism.Type: GrantFiled: January 8, 2016Date of Patent: May 15, 2018Assignee: Oxitec LimitedInventor: Luke Alphey
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Publication number: 20170360015Abstract: Provided is a gene expression system, suitable for expression in an insect, comprising an insect muscle actin promoter operably linked to a marker gene, which overcomes or ameliorates one or more of: cost of rearing; amount of handling; errors in identification due to human error or loss of marker by the insect; and health concerns related to the effects of marker powders on workers in mass rearing facilities.Type: ApplicationFiled: June 23, 2017Publication date: December 21, 2017Applicant: Oxitec LimitedInventors: Martha KOUKIDOU, Sarah SCAIFE, Luke ALPHEY
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Publication number: 20170188559Abstract: Two or more conditional, dominant, lethal gene expression systems provide high levels of penetrance in insects. Lethality is induced at an earlier stage of development and the risk of biochemical resistance is reduced, as compared to a single insect conditional, dominant, lethal gene expression system. The invention is useful for the control of insect populations.Type: ApplicationFiled: June 4, 2015Publication date: July 6, 2017Applicant: Oxitec LimitedInventors: Martha KOUKIDOU, Luke ALPHEY, Simon WARNER
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Publication number: 20170009253Abstract: Provided is an arthropod male germline gene expression system suitable for conditional expression of an effector gene in an Arthropod male germline. The system comprises a first expression unit comprising an effector gene and a promoter therefor operably linked thereto; and a second expression unit. Said second unit comprises a coding sequence for a transcription factor and an upstream regulatory element operably linked thereto, the transcription factor being capable of acting upon the promoter in the first expression unit to drive expression of the effector gene. The upstream regulatory element includes a promoter for the transcription factor; and a 5? UTR adjacent a start site for the transcription factor coding sequence. The upstream regulatory element driving sufficient expression of the transcription factor such that the transcription factor protein in turn drives transcription of the effector gene before meiosis.Type: ApplicationFiled: September 21, 2016Publication date: January 12, 2017Applicant: Oxitec LimitedInventor: Luke ALPHEY
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Patent number: 9487801Abstract: Provided is an arthropod male germline gene expression system suitable for conditional expression of an effector gene in an Arthropod male germline. The system comprises a first expression unit comprising an effector gene and a promoter therefor operably linked thereto; and a second expression unit. Said second unit comprises a coding sequence for a transcription factor and an upstream regulatory element operably linked thereto, the transcription factor being capable of acting upon the promoter in the first expression unit to drive expression of the effector gene. The upstream regulatory element includes a promoter for the transcription factor; and a 5? UTR adjacent a start site for the transcription factor coding sequence. The upstream regulatory element driving sufficient expression of the transcription factor such that the transcription factor protein in turn drives transcription of the effector gene before meiosis.Type: GrantFiled: March 5, 2013Date of Patent: November 8, 2016Assignee: OXITEC LIMITEDInventor: Luke Alphey
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Publication number: 20160122780Abstract: A polynucleotide expression system is provided that is capable of alternative splicing of RNA transcripts of a polynucleotide sequence to be expressed in an organism.Type: ApplicationFiled: January 8, 2016Publication date: May 5, 2016Applicant: Oxitec LimitedInventor: Luke Alphey
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Publication number: 20160106078Abstract: Provided is a gene expression system, suitable for expression in an insect, comprising an insect muscle actin pro-moter operably linked to a marker gene, which overcomes or ameliorates one or more of: cost of rearing; amount of handling; errors in identification due to human error or loss of marker by the insect; and health concerns related to the effects of marker powders on workers in mass rearing facilities.Type: ApplicationFiled: March 5, 2014Publication date: April 21, 2016Applicant: Oxitec LimitedInventors: Martha KOUKIDOU, Sarah SCAIFE, Luke ALPHEY
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Publication number: 20160060651Abstract: A gene expression system is provided. The system comprises at least one coding sequence to be expressed in an organism, and at least one promoter operably linked thereto. It further comprises at least one splice control sequence which, in cooperation with a spliceosome, mediates alternative splicing of RNA transcripts of the coding sequence. The mediation of alternative splicing is in a sex-specific, stage-specific, germline-specific and tissue-specific manner.Type: ApplicationFiled: August 28, 2015Publication date: March 3, 2016Inventor: Luke ALPHEY