Patents by Inventor Luke Benjamin PASE

Luke Benjamin PASE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200339946
    Abstract: The present invention relates to A multicomponent system wherein a first component is an engineered antigen-presenting cell (eAPC) designated component A and a second component is a genetic donor vector, designated component C, for delivery of one or more ORFs encoding an analyte antigen-presenting complex (aAPX) and/or an analyte antigenic molecule (aAM), wherein component A a. Lacks endogenous surface expression of at least one family of aAPX and/or aAM and b. Contains at least two genomic receiver sites, designated component B and component D, each for integration of at least one ORF encoding at least one aAPX and/or aAM, and component C is matched to a component B, and wherein component C is designed to deliver c. A single ORF encoding at least one aAPX and/or aAM or d. Two or more ORF encoding at least one aAPX and/or aAM, wherein the genomic receiver sites B and D are synthetic constructs designed for recombinase mediated exchange (RMCE).
    Type: Application
    Filed: April 30, 2020
    Publication date: October 29, 2020
    Applicant: GENOVIE AB
    Inventors: Reagan Micheal Jarvis, Ryan Edward HILL, Luke Benjamin PASE
  • Publication number: 20200231974
    Abstract: A combined system comprising two separate components, wherein a first component is a vector carrying variable and constant (V-C) T-cell receptor (TCR) gene segments, and a second component is a vector carrying joining (J) TCR gene segments. The combined system may be modified so that said first component is a modified V-C entry vector encoding a first TCR chain, the system further comprises a fourth and a fifth component, wherein the fourth component comprises a Bidirectional Terminator (BiT) donor vector, and the fifth component comprises a modified V-C entry vector encoding a second TCR chain complimentary to said first TCR chain.
    Type: Application
    Filed: July 17, 2018
    Publication date: July 23, 2020
    Applicant: GENOVIE AB
    Inventors: Reagan Micheal Jarvis, Ryan Edward HILL, Luke Benjamin PASE
  • Publication number: 20200115432
    Abstract: The present invention relates to a two-part device, wherein a first part is an engineered antigen-presenting cell system (eAPCS), and a second part is an engineered TCR-presenting cell system (eTPCS).
    Type: Application
    Filed: November 7, 2017
    Publication date: April 16, 2020
    Applicant: GENOVIE AB
    Inventors: Reagan Micheal Jarvis, Ryan Edward HILL, Luke Benjamin PASE
  • Publication number: 20200095574
    Abstract: The present invention relates to a multicomponent system wherein a first component is an engineered TCR-presenting cell (eTPC), designated component A, wherein component A lacks endogenous surface expression of at least one family of analyte antigen-presenting complexes (aAPX) and/or analyte antigenic molecule (aAM), and a second component is a genetic donor vector, designated component C, for delivery of ORF encoding analyte TCR chains.
    Type: Application
    Filed: November 7, 2017
    Publication date: March 26, 2020
    Applicant: GENOVIE AB
    Inventors: Reagan Micheal Jarvis, Ryan Edward HILL, Luke Benjamin PASE
  • Publication number: 20190359934
    Abstract: The present invention relates to A multicomponent system wherein a first component is an engineered antigen-presenting cell (eAPC) designated component A and a second component is a genetic donor vector, designated component C, for delivery of one or more ORFs encoding an analyte antigen-presenting complex (aAPX) and/or an analyte antigenic molecule (aAM), wherein component A a. Lacks endogenous surface expression of at least one family of aAPX and/or aAM and b. Contains at least two genomic receiver GO sites, designated component B and component D, each for integration of at least one ORF encoding at least one aAPX and/or aAM, and component C is matched to a component B, and wherein component C is designed to deliver c. A single ORF encoding at least one aAPX and/or aAM or d. Two or more ORF encoding at least one aAPX and/or aAM, wherein the genomic receiver sites B and D are synthetic constructs designed for re-combinase mediated exchange (RMCE).
    Type: Application
    Filed: November 7, 2017
    Publication date: November 28, 2019
    Applicant: GENOVIE AB
    Inventors: Reagan Micheal Jarvis, Ryan Edward HILL, Luke Benjamin PASE
  • Publication number: 20190283017
    Abstract: The present invention relates to a two-part device, wherein a first part is a multicomponent TCR ORF reconstitution and engineering system (TORES), and a second part is a multicomponent engineered TCR-presenting cell system (eTPCS).
    Type: Application
    Filed: November 7, 2017
    Publication date: September 19, 2019
    Applicant: GENOVIE AB
    Inventors: Reagan Micheal Jarvis, Ryan Edward HILL, Luke Benjamin PASE