Patents by Inventor Luke BORALSKY

Luke BORALSKY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused pyrimidine pyridinone compounds as JAK inhibitors
    Patent number: 11697648
    Abstract: The disclosure provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The disclosure also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal inflammatory diseases.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: July 11, 2023
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Robert Murray McKinnell, Erik Fenster, Tom M. Lam, Diana Jin Wang, Anthony Francesco Palermo, Luke Boralsky, Breena Fraga
  • FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS
    Publication number: 20210188844
    Abstract: The disclosure provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The disclosure also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal inflammatory diseases.
    Type: Application
    Filed: November 24, 2020
    Publication date: June 24, 2021
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Robert Murray McKinnell, Erik Fenster, Tom M. Lam, Diana Jin Wang, Anthony Francesco Palermo, Luke Boralsky, Breena Fraga
  • Bicyclic methylene aziridines and reactions thereof
    Patent number: 9783512
    Abstract: The oxidative functionalization of olefins is a common method for the formation of vicinal carbon-heteroatom bonds. However, oxidative methods to transform allenes into synthetic motifs containing three contiguous carbon-heteroatom bonds are much less developed. The use of bicyclic methylene aziridines (MAs), prepared via intramolecular allene aziridination, as scaffolds for functionalization of all three allene carbons, among other reactions, is described herein.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: October 10, 2017
    Assignee: Wisconsin Alumi Research Foundation
    Inventors: Jennifer Schomaker, Luke Boralsky, John Hershberger, Jared Rigoli, Christopher S. Adams
  • BICYCLIC METHYLENE AZIRIDINES AND REACTIONS THEREOF
    Publication number: 20160075668
    Abstract: The oxidative functionalization of olefins is a common method for the formation of vicinal carbon-heteroatom bonds. However, oxidative methods to transform allenes into synthetic motifs containing three contiguous carbon-heteroatom bonds are much less developed. The use of bicyclic methylene aziridines (MAs), prepared via intramolecular allene aziridination, as scaffolds for functionalization of all three allene carbons, among other reactions, is described herein.
    Type: Application
    Filed: November 13, 2015
    Publication date: March 17, 2016
    Inventors: Jennifer SCHOMAKER, Luke BORALSKY, John HERSHBERGER, Jared RIGOLI, Christopher S. ADAMS
  • Bicyclic methylene aziridines and reactions thereof
    Patent number: 9221842
    Abstract: The oxidative functionalization of olefins is a common method for the formation of vicinal carbon-heteroatom bonds. However, oxidative methods to transform allenes into synthetic motifs containing three contiguous carbon-heteroatom bonds are much less developed. The use of bicyclic methylene aziridines (MAs), prepared via intramolecular allene aziridination, as scaffolds for functionalization of all three allene carbons, among other reactions, is described herein.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: December 29, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jennifer Schomaker, Luke Boralsky, John Hershberger, Jared Rigoli, Christopher S. Adams
  • BICYCLIC METHYLENE AZIRIDINES AND REACTIONS THEREOF
    Publication number: 20130079511
    Abstract: The oxidative functionalization of olefins is a common method for the formation of vicinal carbon-heteroatom bonds. However, oxidative methods to transform allenes into synthetic motifs containing three contiguous carbon-heteroatom bonds are much less developed. The use of bicyclic methylene aziridines (MAs), prepared via intramolecular allene aziridination, as scaffolds for functionalization of all three allene carbons, among other reactions, is described herein.
    Type: Application
    Filed: August 29, 2012
    Publication date: March 28, 2013
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jennifer SCHOMAKER, Luke BORALSKY, John HERSHBERGER, Jared RIGOLI, Christopher S. ADAMS