Patents by Inventor Luke Green

Luke Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190315773
    Abstract: The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: April 13, 2018
    Publication date: October 17, 2019
    Applicants: Hoffmann-La Roche Inc., PTC Therapeutics, Inc.
    Inventors: Hasane Ratni, Luke Green, Maria L. Weetall, Nikolai A. Naryshkin
  • Publication number: 20190138960
    Abstract: A method, a computer system, and a computer program product for digitally presenting a potentially competitive resource allocation for an organization. A computer system identifies employee data for a set of employees. The computer system determines a corresponding business function of a set of business functions for each employee of the set of employees by applying a normalized business function model to the employee data. The computer system determines an aggregate allocation for each business function based on a cumulative compensation of a subset of the set of employees in the corresponding business function. The computer system determines a resource distribution for the organization based on the aggregate allocations for each of the set of business functions. The computer system compares the resource distribution for the organization to a set of benchmark distributions to determine the competitive resource allocation for the organization.
    Type: Application
    Filed: November 6, 2017
    Publication date: May 9, 2019
    Inventors: Xiaojing Wang, Uday Kovur, Venkata Turlapati, Min Xiao, Slawomir Krysiak, Luke Green
  • Publication number: 20180222925
    Abstract: The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: April 9, 2018
    Publication date: August 9, 2018
    Inventors: Amal Dakka, Luke Green, Gary Karp, Jana Narasimhan, Nikolai Naryshkin, Emmanuel Pinard, Hongyan Qi, Hasane Ratni, Nicole Risher, Marla Weetall, Matthew Woll
  • Patent number: 9975900
    Abstract: The present invention provides compounds of formula (I) wherein A, X1, X2, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: May 22, 2018
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Emmanuel Pinard, Hasane Ratni, Luke Green, Patrick Williamson
  • Patent number: 9969754
    Abstract: The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: May 15, 2018
    Assignees: HOFFMANN-LA ROCHE INC., PTC THERAPEUTICS, INC.
    Inventors: Hasane Ratni, Luke Green, Marla L. Weetall, Nikolai A. Naryshkin
  • Publication number: 20180105526
    Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Application
    Filed: December 20, 2017
    Publication date: April 19, 2018
    Inventors: Hongyan QI, Soongyu CHOI, Amal DAKKA, Gary Mitchell KARP, Jana NARASIMHAN, Nikolai NARYSHKIN, Anthony A. TURPOFF, Marla L. WEETALL, Ellen WELCH, Matthew G. WOLL, Tianle YANG, Nanjing ZHANG, Xiaoyan ZHANG, Xin ZHAO, Luke GREEN, Emmanuel PINARD, Hasane RATNI
  • Patent number: 9879007
    Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: January 30, 2018
    Assignees: PTC Therapeutics, Inc., F. Hoffmann-La Roche AG
    Inventors: Hongyan Qi, Soongyu Choi, Amal Dakka, Gary Mitchell Karp, Jana Narasimhan, Nikolai Naryshkin, Anthony A. Turpoff, Marla L. Weetall, Ellen Welch, Matthew G. Woll, Tianle Yang, Nanjing Zhang, Xiaoyan Zhang, Xin Zhao, Luke Green, Emmanuel Pinard, Hasane Ratni
  • Publication number: 20170197990
    Abstract: The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: November 14, 2016
    Publication date: July 13, 2017
    Applicants: Hoffmann-La Roche Inc., PTC Therapeutics, Inc.
    Inventors: Hasane Ratni, Luke Green, Marla L. Weetall, Nikolai A. Naryshkin
  • Publication number: 20170197969
    Abstract: The present invention provides compounds of formula (I) wherein A, X1, X2, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: December 14, 2016
    Publication date: July 13, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Emmanuel PINARD, Hasane RATNI, Luke GREEN, Patrick WILLIAMSON
  • Publication number: 20170129885
    Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Application
    Filed: August 26, 2016
    Publication date: May 11, 2017
    Inventors: Hongyan QI, Soongyu CHOI, Amal DAKKA, Gary Mitchell KARP, Jana NARASIMHAN, Nikolai NARYSHKIN, Anthony A. TURPOFF, Marla L. WEETALL, Ellen WELCH, Matthew G. WOLL, Tianle YANG, Nanjing ZHANG, Xiaoyan ZHANG, Xin ZHAO, Luke GREEN, Emmanuel PINARD, Hasane RATNI
  • Patent number: 9611232
    Abstract: The invention provides compounds having the general formula I wherein n, R1, R2a, R2b, R3a and R3b are as herein defined, composition comprising the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: April 4, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luke Green, Haiyan Wang
  • Patent number: 9586955
    Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: March 7, 2017
    Assignees: PTC Therapeutics, Inc., F. Hoffmann-La Roche AG
    Inventors: Hongyan Qi, Soongyu Choi, Amal Dakka, Gary Mitchell Karp, Jana Narasimhan, Nikolai Naryshkin, Anthony A. Turpoff, Marla L. Weetall, Ellen Welch, Matthew G. Woll, Tianle Yang, Nanjing Zhang, Xiaoyan Zhang, Xin Zhao, Luke Green, Emmanuel Pinard, Hasane Ratni
  • Publication number: 20160214946
    Abstract: A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting a solution of an organic azide and a terminal alkyne with a source of catalytic Ru ion to form a 1,4-disubstituted 1,2,3-triazole.
    Type: Application
    Filed: March 30, 2016
    Publication date: July 28, 2016
    Applicant: The Scripps Research Institute
    Inventors: K. Barry SHARPLESS, Valery FOKIN, Vsevold A. ROSTOVTSEV, Luke GREEN, Fahmi HIMO
  • Publication number: 20160145270
    Abstract: The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: June 23, 2014
    Publication date: May 26, 2016
    Applicants: F. Hoffmann-La Roche AG, PTC Therapeutics Inc.
    Inventors: Amal Dakka, Luke Green, Gary Karp, Jana Narasimhan, Nikolai Naryshkin, Emmanuel Pinard, Hongyan Qi, Hasane Ratni, Nicole Risher, Marla Weetall, Matthew Woll
  • Patent number: 9315498
    Abstract: The present invention relates to ethynyl compounds of formula I-C1 wherein R1, R2, R2?, R3, R3?, R6, U, V and W are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof, which are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: April 19, 2016
    Assignee: HOFFMAN-LA ROCHE INC.
    Inventors: Luke Green, Wolfgang Guba, Georg Jaeschke, Synese Jolidon, Lothar Lindemann, Antonio Ricci, Daniel Rueher, Heinz Stadler, Eric Vieira
  • Patent number: 9302997
    Abstract: A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting a solution of an organic azide and a terminal alkyne with a source of catalytic Cu(I) ion to form a 1,4-disubstituted 1,2,3-triazole, wherein the source of Cu(I) ion comprises Cu(II) and a metal capable of reducing Cu(II) to Cu(I). In some embodiments, the metal capable of reducing Cu(II) to Cu(I) is selected from the group consisting of Al, Be, Co, Cr, Fe, Mg, Mn, Ni, and Zn.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: April 5, 2016
    Assignee: The Scripps Research Institute
    Inventors: K. Barry Sharpless, Valery Fokin, Vsevold A. Rostovtsev, Luke Green, Fahmi Himo
  • Publication number: 20150246894
    Abstract: The invention provides compounds having the general formula I wherein n, R1, R2a, R2b, R3a and R3b are as herein defined, composition comprising the compounds and methods of using the compounds.
    Type: Application
    Filed: April 29, 2015
    Publication date: September 3, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Luke Green, Haiyan Wang
  • Publication number: 20150232432
    Abstract: A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting a solution of an organic azide and a terminal alkyne with a source of catalytic Cu(I) ion to form a 1,4-disubstituted 1,2,3-triazole, wherein the source of Cu(I) ion comprises Cu(II) and a metal capable of reducing Cu(II) to Cu(I). In some embodiments, the metal capable of reducing Cu(II) to Cu(I) is selected from the group consisting of Al, Be, Co, Cr, Fe, Mg, Mn, Ni, and Zn.
    Type: Application
    Filed: May 6, 2015
    Publication date: August 20, 2015
    Applicant: The Scripps Research Institute
    Inventors: K. Barry SHARPLESS, Valery FOKIN, Vsevold A. ROSTOVTSEV, Luke GREEN, Fahmi HIMO
  • Patent number: 9040716
    Abstract: A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion in human blood plasma to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt, Cu(II) ion in the presence of a reducing agent, or copper metal.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: May 26, 2015
    Assignee: The Scripps Research Institute
    Inventors: K. Barry Sharpless, Valery Fokin, Vsevold A. Rostovtsev, Luke Green, Fahmi Himo
  • Publication number: 20150031895
    Abstract: A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion in human blood plasma to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt, Cu(II) ion in the presence of a reducing agent, or copper metal.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 29, 2015
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: K. Barry SHARPLESS, Valery FOKIN, Vsevold A. ROSTOVTSEV, Luke GREEN, Fahmi HIMO