Patents by Inventor Luke Green

Luke Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20240076302
    Abstract: The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: October 27, 2023
    Publication date: March 7, 2024
    Applicants: Hoffmann-La Roche Inc., PTC Therapeutics, Inc.
    Inventors: Hasane RATNI, Luke GREEN, Marla L. WEETALL, Nikolai A. NARYSHKIN
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20240067646
    Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Application
    Filed: July 26, 2023
    Publication date: February 29, 2024
    Inventors: Hongyan QI, Soongyu CHOI, Amal DAKKA, Gary Mitchell KARP, Jana NARASIMHAN, Nikolai NARYSHKIN, Anthony A. TURPOFF, Marla L. WEETALL, Ellen WELCH, Matthew G. WOLL, Tianle YANG, Nanjing ZHANG, Xiaoyan ZHANG, Xin ZHAO, Luke GREEN, Emmanuel PINARD, Hasane RATNI
  • PYRAZOLEAMIDE DERIVATIVES
    Publication number: 20230382911
    Abstract: The present invention provides compounds of formula I or II: wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: July 28, 2023
    Publication date: November 30, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Andrew Simon BELL, Jérémy BESNARD, Anthony Richard BRADLEY, Luke GREEN, Wolfgang HAAP, Buelent KOCER, Andreas KUGLSTATTER, Xavier LUCAS, Patrizio MATTEI, Dmitry MAZUNIN, Claus RIEMER, Willem Paul VAN HOORN
  • Compounds for treating spinal muscular atrophy
    Patent number: 11827646
    Abstract: The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: November 28, 2023
    Assignees: Hoffmann-La Roche Inc., PTC Therapeutics, Inc.
    Inventors: Hasane Ratni, Luke Green, Marla L. Weetall, Nikolai A. Naryshkin
  • Compounds for treating spinal muscular atrophy
    Patent number: 11753407
    Abstract: Provided herein are compounds of Formula (I): and forms thereof, wherein w1, w2, w3, w4, w5, w6 and w7 are as defined herein, including compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: September 12, 2023
    Assignees: PTC Therapeutics, Inc., F. Hoffmann-La Roche AG
    Inventors: Hongyan Qi, Soongyu Choi, Amal Dakka, Gary Mitchell Karp, Jana Narasimhan, Nikolai Naryshkin, Anthony A. Yurpoff, Marla L. Weetall, Ellen Welch, Matthew G. Woll, Tianle Yang, Nanjing Zhang, Xiaoyan Zhang, Xin Zhao, Luke Green, Emmanuel Pinard, Hasane Ratni
  • AMIDOPYRIMIDONE DERIVATIVES
    Publication number: 20230227449
    Abstract: The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: December 19, 2022
    Publication date: July 20, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Andrew Simon Bell, Jérémy Besnard, Anthony Richard Bradley, Luke Green, Wolfgang Haap, Buelent Kocer, Andreas Kuglstatter, Xavier Lucas, Patrizio Mattei, Dmitry Mazunin, Hasane Ratni, Claus Riemer, Willem Paul Van Hoorn
  • SULFONE DERIVATIVES
    Publication number: 20230219953
    Abstract: The present invention provides compounds of formula I wherein X1, X2, X3, X4, R1, R1a, R1b, R2?, R2?, R3?, R3?, R6 and R7 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: December 19, 2022
    Publication date: July 13, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Andrew Simon Bell, Jérémy Besnard, Anthony Richard Bradley, Luke Green, Wolfgang Haap, Buelent Kocer, Andreas Kuglstatter, Xavier Lucas, Patrizio Mattei, Dmitry Mazunin, Claus Riemer, Willem Paul Van Hoorn
  • AMINO-PYRIMIDINE AMIDES
    Publication number: 20230174516
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 7, 2022
    Publication date: June 8, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Angelica BEURIER, Michail Konstantinos BOGDOS, Luke GREEN, Christian KRAMER, Dmitry MAZUNIN, Emmanuel PINARD, Hasane RATNI
  • AMINO-PYRIMIDINE CYCLO-AMIDES
    Publication number: 20230123268
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3 and n are as defined herein, compositions including methods of making the compounds and using the compounds as ATX inhibitors.
    Type: Application
    Filed: December 7, 2022
    Publication date: April 20, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Angélica BEURIER, Luke GREEN, Christian KRAMER, Dmitry MAZUNIN, Emmanuel PINARD, Hasane RATNI
  • SUBSTITUED AMINO-PYRIMIDINES
    Publication number: 20230112172
    Abstract: The invention provides novel compounds having the general formula I wherein R1, R2, and R3 are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 7, 2022
    Publication date: April 13, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Virginie BROM, Luke GREEN, Christian KRAMER, Dmitry MAZUNIN, Emmanuel PINARD, Hasane RATNI
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20210276999
    Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Application
    Filed: October 5, 2020
    Publication date: September 9, 2021
    Inventors: Hongyan QI, Soongyu CHOI, Amal DAKKA, Gary Mitchell KARP, Jana NARASIMHAN, Nikolai NARYSHKIN, Anthony A. TURPOFF, Marla L. WEETALL, Ellen WELCH, Matthew G. WOLL, Tianle YANG, Nanjing ZHANG, Xiaoyan ZHANG, Xin ZHAO, Luke GREEN, Emmanuel PINARD, Hasane RATNI
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20210147447
    Abstract: The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: November 16, 2020
    Publication date: May 20, 2021
    Applicants: Hoffmann-La Roche Inc., PTC Therapeutics, Inc.
    Inventors: Hasane Ratni, Luke Green, Marla L. Weetall, Nikolai A. Naryshkin
  • Compounds for treating spinal muscular atrophy
    Patent number: 10882868
    Abstract: The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: January 5, 2021
    Assignees: Hoffmann-La Roche Inc., PTC Theranentics. Inc.
    Inventors: Hasane Ratni, Luke Green, Marla L. Weetall, Nikolai A. Naryshkin
  • Compounds for treating spinal muscular atrophy
    Patent number: 10851101
    Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: December 1, 2020
    Assignees: PTC Therapeutics, Inc., F. Hoffman-La Roche AG
    Inventors: Hongyan Qi, Soongyu Choi, Amal Dakka, Gary Mitchell Karp, Jana Narasimhan, Nikolai Naryshkin, Anthony A. Turpoff, Marla L. Weetall, Ellen Welch, Matthew G. Woll, Tianle Yang, Nanjing Zhang, Xiaoyan Zhang, Xin Zhao, Luke Green, Emmanuel Pinard, Hasane Ratni
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20190375750
    Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
    Type: Application
    Filed: August 15, 2019
    Publication date: December 12, 2019
    Inventors: Hongyan QI, Soongyu CHOI, Amal DAKKA, Gary Mitchell KARP, Jana NARASIMHAN, Nikolai NARYSHKIN, Anthony A. TURPOFF, Marla L. WEETALL, Ellen WELCH, Matthew G. WOLL, Tianle YANG, Nanjing ZHANG, Xiaoyan ZHANG, Xin ZHAO, Luke GREEN, Emmanuel PINARD, Hasane RATNI
  • Compounds for treating spinal muscular atrophy
    Patent number: 10501482
    Abstract: The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: December 10, 2019
    Assignees: Hoffmann—La Roche Inc., PTC Therapeutics Inc.
    Inventors: Amal Dakka, Luke Green, Gary Karp, Jana Narasimhan, Nikolai Naryshkin, Emmanuel Pinard, Hongyan Qi, Hasane Ratni, Nicole Risher, Marla Weetall, Matthew Woll
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20190315773
    Abstract: The present invention provides compounds of formula (I) wherein A, R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: April 13, 2018
    Publication date: October 17, 2019
    Applicants: Hoffmann-La Roche Inc., PTC Therapeutics, Inc.
    Inventors: Hasane Ratni, Luke Green, Maria L. Weetall, Nikolai A. Naryshkin
  • Information System with Embedded Insights
    Publication number: 20190138960
    Abstract: A method, a computer system, and a computer program product for digitally presenting a potentially competitive resource allocation for an organization. A computer system identifies employee data for a set of employees. The computer system determines a corresponding business function of a set of business functions for each employee of the set of employees by applying a normalized business function model to the employee data. The computer system determines an aggregate allocation for each business function based on a cumulative compensation of a subset of the set of employees in the corresponding business function. The computer system determines a resource distribution for the organization based on the aggregate allocations for each of the set of business functions. The computer system compares the resource distribution for the organization to a set of benchmark distributions to determine the competitive resource allocation for the organization.
    Type: Application
    Filed: November 6, 2017
    Publication date: May 9, 2019
    Inventors: Xiaojing Wang, Uday Kovur, Venkata Turlapati, Min Xiao, Slawomir Krysiak, Luke Green
  • COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
    Publication number: 20180222925
    Abstract: The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: April 9, 2018
    Publication date: August 9, 2018
    Inventors: Amal Dakka, Luke Green, Gary Karp, Jana Narasimhan, Nikolai Naryshkin, Emmanuel Pinard, Hongyan Qi, Hasane Ratni, Nicole Risher, Marla Weetall, Matthew Woll
  • Substituted imidazo[1,2-?]pyrazines for treating spinal muscular atrophy
    Patent number: 9975900
    Abstract: The present invention provides compounds of formula (I) wherein A, X1, X2, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: May 22, 2018
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Emmanuel Pinard, Hasane Ratni, Luke Green, Patrick Williamson