Abstract: The present disclosure and invention relates to a chimeric protein useful in adoptive cell therapy (ACT) which is a membrane-associated signalling protein that can be induced to provide a cell expressing the protein with a STAT-5-mediated signal. Also provided are nucleic acid molecules encoding such a chimeric protein, 5 recombinant constructs, vectors and cells containing the nucleic acid molecule, methods of producing such cells, and therapeutic uses thereof.

Abstract: A method of repairing a tip for an airfoil is disclosed herein. In various embodiments, the method comprises: removing a portion of the airfoil that reduces a radial height of the airfoil and at least partially removes a defect of the airfoil; removing a remainder of the defect; joining, via gas tungsten arc welding, a filler material to the airfoil to repair the defect; and joining a first mating surface of the airfoil to a second mating surface of a blade tip body via a solid-state joining process.

Abstract: Various methods and systems are provided for indexing an injector map and subsequently controlling fuel injection to an engine. In one embodiment, a method for the engine includes injecting fuel via activating an injector for a determined activation time, the activation time determined based on a commanded fuel value and a function of a modified pressure difference across an orifice of a nozzle of the injector, where the modified pressure difference is based on a difference between a rail pressure and peak cylinder pressure, the peak cylinder pressure scaled by a function of engine speed and injection timing and the pressure difference offset by a correction factor.

Abstract: Various methods and systems are provided for indexing an injector map and subsequently controlling fuel injection to an engine. In one embodiment, a method for the engine includes injecting fuel via activating an injector for a determined activation time, the activation time determined based on a commanded fuel value and a function of a modified pressure difference across an orifice of a nozzle of the injector, where the modified pressure difference is based on a difference between a rail pressure and peak cylinder pressure, the peak cylinder pressure scaled by a function of engine speed and injection timing and the pressure difference offset by a correction factor.

Abstract: Various methods for controlling EGR rate are disclosed. In one embodiment, a method comprises routing at least a portion of exhaust from a first exhaust manifold to an intake manifold, and not to atmosphere, the first exhaust manifold exclusively coupled to a first cylinder group. The method further includes routing exhaust from at least one additional exhaust manifold coupled to a corresponding at least one additional cylinder group to atmosphere, and during a first engine operating condition where an engine fuel demand is below a threshold demand, not injecting fuel to each of a subset of cylinders in the first cylinder group while injecting fuel to a subset of all cylinders coupled to the at least one additional exhaust manifold, where a number of cylinders of the subset of cylinders in the first cylinder group decreases in response to an increase in a target EGR rate.

Abstract: Various methods for controlling EGR rate are disclosed. In one embodiment, a method comprises routing at least a portion of exhaust from a first exhaust manifold to an intake manifold, and not to atmosphere, the first exhaust manifold exclusively coupled to a first cylinder group. The method further includes routing exhaust from at least one additional exhaust manifold coupled to a corresponding at least one additional cylinder group to atmosphere, and during a first engine operating condition where an engine fuel demand is below a threshold demand, not injecting fuel to each of a subset of cylinders in the first cylinder group while injecting fuel to a subset of all cylinders coupled to the at least one additional exhaust manifold, where a number of cylinders of the subset of cylinders in the first cylinder group decreases in response to an increase in a target EGR rate.

Abstract: Various methods for controlling EGR rate are disclosed. In one embodiment, a method comprises routing at least a portion of exhaust from a first exhaust manifold to an intake manifold, and not to atmosphere, the first exhaust manifold exclusively coupled to a first cylinder group. The method further includes routing exhaust from at least one additional exhaust manifold coupled to a corresponding at least one additional cylinder group to atmosphere, and during a first engine operating condition where an engine fuel demand is below a threshold demand, not injecting fuel to each of a subset of cylinders in the first cylinder group while injecting fuel to a subset of all cylinders coupled to the at least one additional exhaust manifold, where a number of cylinders of the subset of cylinders in the first cylinder group decreases in response to an increase in a target EGR rate.

Abstract: A method for controlling an engine includes the steps of, in response to a transient operating event, determining a first amount of exhaust gas recirculation (EGR) that if provided to an intake of the engine would avoid turbocharger compressor surge in a turbocharger, determining a second amount of EGR that if provided to the intake would avoid turbocharger compressor choke in the turbocharger, and determining a third amount of EGR that if provided to the intake would avoid engine smoking, and adjusting EGR provided to the intake of the engine in accordance with the determined first, second, and third amounts.

Abstract: Various methods and systems are provided for adjusting a flow of exhaust gas in an exhaust gas recirculation system. In one embodiment, a method for an engine comprises controlling a flow of exhaust gas through an exhaust gas recirculation system of an engine system based on a choke level of a turbocharger. For example, the flow of exhaust gas in the exhaust gas recirculation system may be reduced to within a threshold of a choke level of the turbocharger, in response to an ambient condition.

Abstract: Various methods and systems are provided for controlling air flow in a two-stage turbocharger. In one example, an engine method comprises adjusting one or more exhaust gas recirculation valves to maintain a first turbocharger within a first air flow range, and adjusting a turbocharger bypass valve to maintain a second turbocharger within a second air flow range.

Abstract: Various embodiments of methods and systems are provided for enhancing engine operation through data-sharing among vehicles. In one embodiment, a method includes determining whether a first value of a first operating parameter produced by a first vehicle is corrupted or unavailable; receiving a second value of the first operating parameter produced by a second vehicle that is proximate to the first vehicle; adjusting the second value by a first adjustment factor, the first adjustment factor based on a first value of a global positioning system (GPS) position of the first vehicle produced by the first vehicle and a second value of a GPS position of the second vehicle produced by the second vehicle; and in response to determining that the first value is corrupted or unavailable, controlling operation of an engine of the first vehicle based on the adjusted second value of the first operating parameter.

Abstract: Various systems and method for controlling exhaust gas recirculation (EGR) in an internal combustion engine are provided. In one embodiment, a method includes during a first operating condition, directing exhaust gas from a first cylinder group into an engine air intake stream and directing substantially no exhaust gas from a second cylinder group to the engine air intake stream. The method further includes during a second operating condition, directing exhaust gas from the second cylinder group through a turbocharger bypass into the engine air intake stream and reducing a fuel injection amount of the first cylinder group relative to a fuel injection amount of the second cylinder group.

Abstract: Dynamic health assessment systems and methods related to monitoring fuel flow control are provided. In one embodiment, a method for controlling a system having an engine is provided. The method includes during a no-load condition of the engine, stopping fuel injection by a plurality of fuel injectors of the engine, closing a valve that is operable to control fuel flow to a fuel pump that pumps fuel to a common fuel rail, and setting a degradation condition in response to a fuel rail pressure decay rate of a fuel pressure in the common fuel rail being greater than a decay threshold after a first designated duration.

Abstract: Various systems and method for controlling exhaust gas recirculation (EGR) in an internal combustion engine are provided. In one embodiment, a method includes injecting fuel to a subset of cylinders that includes less than all cylinders of a first cylinder group to obtain a target EGR rate. The first cylinder group provides exhaust gas through an exhaust gas recirculation (EGR) passage structure fluidly coupled between the first cylinder group and an intake passage structure. The method further includes injecting fuel to at least one cylinder of a second cylinder group. The second cylinder group provides substantially no exhaust gas through the EGR passage structure.

Abstract: Various methods and systems are provided for engine operation with a degraded turbocharger. In one embodiment, a method for an engine comprises reducing mass flow through a first turbocharger while continuing engine operation and adjusting operation of a second turbocharger in response to detected degradation of the first turbocharger.

Abstract: Various methods for controlling EGR rate are disclosed. In one embodiment, a method comprises routing at least a portion of exhaust from a first exhaust manifold to an intake manifold, and not to atmosphere, the first exhaust manifold exclusively coupled to a first cylinder group. The method further includes routing exhaust from at least one additional exhaust manifold coupled to a corresponding at least one additional cylinder group to atmosphere, and during a first engine operating condition where an engine fuel demand is below a threshold demand, not injecting fuel to each of a subset of cylinders in the first cylinder group while injecting fuel to a subset of all cylinders coupled to the at least one additional exhaust manifold, where a number of cylinders of the subset of cylinders in the first cylinder group decreases in response to an increase in a target EGR rate.

Abstract: Various methods and systems are provided for estimating a wall temperature in a heat exchanger and reducing the risk of boiling on a coolant side of the heat exchanger. In one embodiment, a method for an engine comprises estimating a wall temperature at a location in a heat exchanger and adjusting an engine operating parameter of an engine coupled to the heat exchanger based on the wall temperature.

Abstract: Various methods and systems are provided for lowering exhaust gas temperature. In one embodiment, a method comprises increasing an air-to-fuel ratio of an engine in response to an exhaust gas temperature exceeding a threshold temperature value to lower the exhaust gas temperature to a temperature below the threshold temperature value.

Abstract: Various methods and systems are provided for indexing an injector map and subsequently controlling fuel injection to an engine. In one embodiment, a non-transitory computer readable storage medium with memory comprises fuel injector activation data indexed in the memory according to an input parameter, instructions for determining a modified pressure value based on a determined pressure and a modified pressure function, and instructions for generating a fuel injector activation output by interpolating among the indexed fuel injector activation data with the modified pressure value as the input parameter.

Abstract: Various methods and systems are provided for determining a surge level of a compressor. In one embodiment, a method for an engine comprises updating a stored estimate of a surge level of a compressor responsive to detection of a surge event.