Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

Abstract: Catheter apparatuses, systems, and methods for cryogenically modulating neural structures of the renal plexus by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a cryo-applicator to a renal artery via an intravascular path. Cryogenic renal neuromodulation may be achieved via application of cryogenic temperatures to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract: A mechanism for adjusting the chordae connecting the leaflets of a mitral valve to the papillary muscles in order to restore normal functioning of the mitral valve. The devices or mechanisms can correct problems associated with both prolapsed leaflets and restricted leaflets to allow the leaflets to properly coapt, thereby preventing or minimizing regurgitation. In accordance with the invention, the mechanisms or devices used for adjusting the chordae can be delivered and implanted in a minimally invasive and/or percutaneous manner, such as via transapical methods, transfermoral methods, or trans-septal methods.

Abstract: A rapid exchange catheter is disclosed having a single lumen proximal shaft portion with a helical coil or helically cut hypotube component extending within a lumen thereof. The helical coil or helically cut hypotube component provides stiffness and pushability to the catheter. A proximal end of helical coil or helically cut hypotube component is attached within a luer fitting at a proximal end of the proximal shaft portion, such that the helical coil or helically cut hypotube component extends within the proximal shaft lumen in a somewhat cantilevered arrangement unsupported and unattached at any point along its length with the proximal shaft portion. As such, the helical coil or helically cut hypotube component moves independent of the proximal shaft portion to adjust to the twists and turns of the vasculature independent of the proximal shaft portion.

Abstract: A catheter includes elongate flexible inner and outer tubular lumens having proximal and distal regions, and a plurality of exit markers formed in the proximal region. The inner tubular lumen includes an outer surface, and an inner surface, the inner surface defining a guidewire passageway. The outer tubular lumen includes an elongate, flexible, and substantially transparent outer tubular lumen having an outer surface, and an inner surface surrounding the inner tubular lumen. The exit markers may be formed on the inner tubular lumen outer surface or on the outer tubular lumen inner surface, the exit markers being visible to the naked eye through the substantially transparent outer tubular lumen outer surface. The exit markers may also be integrally formed from a polymer that forms a portion of the proximal region of the outer tubular lumen or the inner tubular lumen.