Patents by Inventor Luke J. Whitesell

Luke J. Whitesell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HSF1 as a marker in tumor prognosis and treatment
    Patent number: 9696313
    Abstract: In some aspects, the invention relates to Heat Shock Protein-1 (HSF1) gene and HSF1 gene products. In some aspects, the invention provides methods of tumor diagnosis, prognosis, treatment-specific prediction, or treatment selection, the methods comprising assessing the level of HSF1 expression or HSF1 activation in a sample obtained from the tumor. In some aspects, the invention relates to the discovery that increased HSF1 expression and increased HSF1 activation correlate with poor outcome in cancer, e.g., breast cancer.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: July 4, 2017
    Assignees: Whitehead Institute for Biomedical Research, The Brigham and Women's Hospital, Inc.
    Inventors: Sandro Santagata, Susan Lindquist, Luke J. Whitesell, Tan A. Ince
  • HSF1 IN TUMOR STROMA
    Publication number: 20170037480
    Abstract: In some aspects, the invention relates to Heat Shock Protein-1 (HSF1) gene and HSF1 gene products in tumor stroma. In some aspects, the invention provides methods of tumor prognosis, treatment-specific prediction, or treatment selection, the methods comprising measuring the level of HSF1 expression or HSF1 activation in a sample obtained from the tumor that comprises tumor-associated stromal cells. In some aspects, the invention relates to the discovery that increased HSF1 expression and increased HSF1 activation in tumor-associated stromal cells correlate with poor outcome in cancer. In some embodiments, the methods comprise measuring HSF1 expression or activation specifically in tumor-associated stromal cells. In some embodiments, the methods comprise measuring HSF1 expression or activation specifically in tumor-associated stromal cells and specifically in cancer cells. In some embodiments HSF1 expression or activation is measured using an antibody that specifically binds to HSF1.
    Type: Application
    Filed: April 13, 2015
    Publication date: February 9, 2017
    Inventors: Ruth Scherz-Shouval, Susan Lindquist, Luke J. Whitesell, Sandro Santagata, Marc Mendillo
  • HSF1 AND HSF1 CANCER SIGNATURE SET GENES AND USES RELATING THERETO
    Publication number: 20150241436
    Abstract: In some aspects, the invention relates to Heat Shock Protein-1 (HSF1) gene and HSF1 gene products. In some aspects, the invention provides methods of tumor diagnosis, prognosis, treatment-specific prediction, or treatment selection, the methods comprising assessing the level of HSF1 expression or HSF1 activation in a sample obtained from the tumor. In some aspects, the invention relates to the discovery that increased HSF1 expression and increased HSF1 activation correlate with poor outcome in cancer, e.g., breast cancer. In some aspects, the invention relates to the HSF1 cancer program genes, HSF1 cancer signature set genes, subsets thereof, and uses in tumor diagnosis, prognosis, treatment-specific prediction, treatment selection, or drug discovery, among others.
    Type: Application
    Filed: May 3, 2013
    Publication date: August 27, 2015
    Inventors: Sandro Santagata, Susan Lindquist, Marc Mendillo, Luke J. Whitesell
  • HSF1 AS A MARKER IN TUMOR PROGNOSIS AND TREATMENT
    Publication number: 20140234858
    Abstract: In some aspects, the invention relates to Heat Shock Protein-1 (HSF1) gene and HSF1 gene products. In some aspects, the invention provides methods of tumor diagnosis, prognosis, treatment-specific prediction, or treatment selection, the methods comprising assessing the level of HSF1 expression or HSF1 activation in a sample obtained from the tumor. In some aspects, the invention relates to the discovery that increased HSF1 expression and increased HSF1 activation correlate with poor outcome in cancer, e.g., breast cancer.
    Type: Application
    Filed: October 5, 2012
    Publication date: August 21, 2014
    Inventors: Sandro Santagata, Susan Lindquist, Luke J. Whitesell, Tan A. Ince