Patents by Inventor Luke Macyszyn

Luke Macyszyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11488717
    Abstract: A method for analysis of spine anatomy and stenosis is disclosed herein. The method includes preprocessing (3203) of images and then running segmentation models for each area of interest such as the foramen, disc, canal, vertebra (3206). In image post processing (3207), the system runs various heuristics to ensure accuracy (3208), computes areas (3209), and then runs a comparison model (3210). The report template produces HTML that is then converted to a PDF file of the final report (3214).
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: November 1, 2022
    Assignee: Theseus AI, Inc.
    Inventors: Billy Cao, Dave Harrison, Luke Macyszyn, Sam Elhag
  • Publication number: 20200406039
    Abstract: A spinal cord stimulator includes: (1) a flexible substrate; (2) a power source embedded in the flexible substrate; (3) a controller embedded in the flexible substrate and connected to the power source; and (4) an array of electrodes, including an array of stimulation electrodes, disposed over the flexible substrate and connected to the controller, wherein the controller is configured to direct the array of stimulation electrodes to deliver a stimulation pattern to a spinal cord of a patient.
    Type: Application
    Filed: March 15, 2019
    Publication date: December 31, 2020
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Bilwaj Gaonkar, Steven L. Moran, Amir Hanna, Luke Macyszyn, Subramanian S. Iyer
  • Publication number: 20200373013
    Abstract: A method for analysis of spine anatomy and stenosis is disclosed herein. The method includes preprocessing (3203) of images and then running segmentation models for each area of interest such as the foramen, disc, canal, vertebra (3206). In image post processing (3207), the system runs various heuristics to ensure accuracy (3208), computes areas (3209), and then runs a comparison model (3210). The report template produces HTML that is then converted to a PDF file of the final report (3214).
    Type: Application
    Filed: May 19, 2020
    Publication date: November 26, 2020
    Applicant: Theseus AI, Inc.
    Inventors: Billy Cao, Dave Harrison, Luke Macyszyn, Sam Elhag
  • Patent number: 10481233
    Abstract: Edema invariant tractography methods are provided. The methods include acquiring data using a multishell, high angular resolution diffusion imaging sequence; (ii) modeling the data using a multi-compartment model; and (iii) reconstructing the fibers through a probabilistic tracking algorithm using a fiber orientation distribution which has streamlines fitted to the output of said probabilistic tracking algorithm.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: November 19, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ragini Verma, Luke Macyszyn, Emmanuel Caruyer, Jeremy Lecoeur, Mark Elliot, Steven Brem
  • Publication number: 20190085407
    Abstract: An isoform-level gene panel is disclosed that can accurately classify a glioblastoma subtype from a tumor sample. Such an isoform level gene panel comprises the 121 to 214 target isoforms identified in Table 1. Also disclosed are reagents for quantitively detecting the expression or activity of the target isoforms of Table 1 in a patient sample. For example, such ligands can be PCR primer and probes sets. This isoform-level gene panel and reagents for detection of the isoforms are useful in an isoform-level assay for diagnosis of the molecular subtype of a glioblastoma in a patient. The assay employs algorithms and a novel computer program that performs the functions of FIG. 8. In one aspect, the assay is a high-throughput format.
    Type: Application
    Filed: October 17, 2018
    Publication date: March 21, 2019
    Inventors: Ramana V. Davuluri, Sharmistha Pal, Yingtao Bi, Louise C. Showe, Donald M. O'Rourke, Luke Macyszyn
  • Patent number: 10113201
    Abstract: An isoform-level gene panel is disclosed that can accurately classify a glioblastoma subtype from a tumor sample. Such an isoform level gene panel comprises the 121 to 214 target isoforms identified in Table 1. Also disclosed are reagents for quantitatively detecting the expression or activity of the target isoforms of Table 1 in a patient sample. For example, such ligands can be PCR primer and probes sets. This isoform-level gene panel and reagents for detection of the isoforms are useful in an isoform-level assay for diagnosis of the molecular subtype of a glioblastoma in a patient. The assay employs algorithms and a novel computer program that performs the functions of FIG. 8. In one aspect, the assay is a high-throughput format.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: October 30, 2018
    Assignees: The Wistar Institute of Anatomy and Biology, The Trustees of the University of Pennsylvania
    Inventors: Ramana V. Davuluri, Sharmistha Pal, Yingtao Bi, Louise C. Showe, Donald M. O'Rourke, Luke Macyszyn
  • Publication number: 20170285124
    Abstract: Edema invariant tractography methods are provided. The methods include acquiring data using a multishell, high angular resolution diffusion imaging sequence; (ii) modeling the data using a multi-compartment model; and (iii) reconstructing the fibers through a probabilistic tracking algorithm using a fiber orientation distribution which has streamlines fitted to the output of said probabilistic tracking algorithm.
    Type: Application
    Filed: September 8, 2015
    Publication date: October 5, 2017
    Inventors: Ragini Verma, Luke Macyszyn, Emmanuel Caruyer, Jeremy Lecoeur, Mark Elliot, Steven Brem
  • Publication number: 20160060704
    Abstract: An isoform-level gene panel is disclosed that can accurately classify a glioblastoma subtype from a tumor sample. Such an isoform level gene panel comprises the 121 to 214 target isoforms identified in Table 1. Also disclosed are reagents for quantitatively detecting the expression or activity of the target isoforms of Table 1 in a patient sample. For example, such ligands can be PCR primer and probes sets. This isoform-level gene panel and reagents for detection of the isoforms are useful in an isoform-level assay for diagnosis of the molecular subtype of a glioblastoma in a patient. The assay employs algorithms and a novel computer program that performs the functions of FIG. 8. In one aspect, the assay is a high-throughput format.
    Type: Application
    Filed: April 4, 2014
    Publication date: March 3, 2016
    Inventors: Ramana V. Davuluri, Sharmistha Pal, Yingtao Bi, Louise C. Showe, Donald M. O'Rourke, Luke Macyszyn