Patents by Inventor Luke Masson

Luke Masson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for the production of diphtheria toxin polypeptides
    Publication number: 20230331788
    Abstract: An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
    Type: Application
    Filed: May 30, 2023
    Publication date: October 19, 2023
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Luke MASSON, Melanie ARBOUR, Marie-Anne GAURIAT
  • Systems and methods for the production of diphtheria toxin polypeptides
    Patent number: 11702456
    Abstract: An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: July 18, 2023
    Assignee: National Research Council of Canada
    Inventors: Luke Masson, Melanie Arbour, Marie-Anne Gauriat
  • RECOMBINANT INTERFERON
    Publication number: 20220323546
    Abstract: Isolated, pure, soluble isoform free recombinant human interferon alpha 2b (rhIFN ?-2b). Methods of making the soluble isoform free rhIFN ?-2b. Stable compositions and formulations of isoform free rhIFN ?-2b are for administration generally for treatment and prevention of viral infections. In aspects, to prevent and/or minimize symptom(s) of viral infections such as respiratory infection(s) in a subject, in aspects SARS-COV2 infection.
    Type: Application
    Filed: April 20, 2021
    Publication date: October 13, 2022
    Inventors: SCOTT RUDGE, LUKE MASSON, MÉLANIE ARBOUR, JULIE STRUBLE, JENAE LUELLEN
  • Systems and methods for the production of diphtheria toxin polypeptides
    Publication number: 20200231635
    Abstract: An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
    Type: Application
    Filed: August 16, 2018
    Publication date: July 23, 2020
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Luke MASSON, Melanie ARBOUR, Marie-Anne GAURIAT
  • Virulence and antibiotic resistance array and uses thereof
    Publication number: 20060094034
    Abstract: An array of nucleic acid probes is described for simultaneously identifying or characterizing a pathotype of a microorganism and detecting antibiotic resistance of said microorganism. Methods are also described for detecting the presence of a microorganism in a sample, as well as determining its pathotype and its antibiotic resistance, using the array.
    Type: Application
    Filed: May 25, 2005
    Publication date: May 4, 2006
    Inventors: Roland Brousseau, Jason Dubois, Tom Edge, Luke Masson, Jack Trevors
  • DNA microarray for fingerprinting and characterization of microorganisms in microbial communities
    Publication number: 20050260619
    Abstract: An array of nucleic acid probes is described for identifying and/or characterizing a microorganism. Methods are also described for detecting the presence of a microorganism in a sample, as well as determining its pathotype, using the array. Methods of assessing related infection and disease in a subject using the array are also described. Methods that characterize complex microbial communities using the array are also described.
    Type: Application
    Filed: February 11, 2005
    Publication date: November 24, 2005
    Inventors: Roland Brousseau, Jason Dubois, Tom Edge, Luke Masson, Jack Trevors