Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: In various embodiments, a wake diversion system operates to manipulate the characteristics of the stern waves produced by a watercraft as it passes through water. In one embodiment, the wake diversion system includes a wake diverter that is comprised of a body, a panel, and a plurality of boat attachment mechanisms. The wake diverter is removably attachable to the side of the hull of a watercraft such that it obstructs the natural flow of water around the hull of the watercraft on side of the watercraft to which it is attached.

Abstract: In various embodiments, a wake diversion system operates to manipulate the characteristics of the stern waves produced by a watercraft as it passes through water. In one embodiment, the wake diversion system includes a wake diverter that is comprised of a body, a panel, and a plurality of boat attachment mechanisms. The wake diverter is removably attachable to the side of the hull of a watercraft such that it obstructs the natural flow of water around the hull of the watercraft on side of the watercraft to which it is attached.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: The present invention relates to compounds of formula (X) or pharmaceutically acceptable salts thereof, wherein R1-R50, a, b, d, e, f, g, h, i, j, k, l, o, p, q, r, s, t, u, y, and z are defined herein. The novel dihydropyrrolopyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: The present invention relates to compounds of formula (X) or pharmaceutically acceptable salts thereof, wherein R1-R50, a, b, d, e, f, g, h, i, j, k, l, o, p, q, r, s, t, u, y, and z are defined herein. The novel dihydropyrrolopyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: A real time clock circuit is provided that has an onboard oscillator continuously providing an internal clock frequency, which is digitally synchronized to a more accurate reference clock frequency. An exemplary real time clock inhibits synchronization of the internal clock frequency when the reference clock is unavailable or if the reference clock's frequency is outside of a defined accuracy range.

Abstract: A real time clock circuit is provided that has an onboard oscillator continuously providing an internal clock frequency, which is digitally synchronized to a more accurate reference clock frequency. An exemplary real time clock inhibits synchronization of the internal clock frequency when the reference clock is unavailable or if the reference clock's frequency is outside of a defined accuracy range.

Abstract: A coupling assembly for plastic pipes including a nut, a body, a grip-ring, and a seal. The nut can engage the body through appropriate threads and includes a hooked projection having a sloping surface adapted to abut against and provide a force on a corresponding surface of the grip ring within the body. A pipe is inserted through the nut, grip-ring, and seal into the body. Tightening of the nut causes its sloped surface to engage and the grip ring to be forced both radially and longitudinally. Radial compression results in the grip-ring engaging the pipe whilst longitudinal forcing causes it to be forced into the body simultaneously abutting against and compressing the seal whilst dragging the pipe further into the body. The nut and the body may further have tapered surfaces that are brought together as the grip-ring is forced into the body. The physical connection between the body and the nut provides reinforcing for the nut, a feature especially useful when dealing with soft plastics.

Abstract: A coupling assembly for plastic pipes including a nut, a body, a grip-ring, and a seal. The nut can engage the body through appropriate threads and includes a hooked projection having a sloping surface adapted to abut against and provide a force on a corresponding surface of the grip ring within the body. A pipe is inserted through the nut, grip-ring, and seal into the body. Tightening of the nut causes its sloped surface to engage and the grip ring to be forced both radially and longitudinally. Radial compression results in the grip-ring engaging the pipe whilst longitudinal forcing causes it to be forced into the body simultaneously abutting against and compressing the seal whilst dragging the pipe further into the body. The nut and the body may further have tapered surfaces that are brought together as the grip-ring is forced into the body. The physical connection between the body and the nut provides reinforcing for the nut, a feature especially useful when dealing with soft plastics.

Abstract: A coupling assembly for plastic pipes including a nut, a body, a grip-ring, and a seal. The nut can engage the body through appropriate threads and includes a hooked projection having a sloping surface adapted to abut against and provide a force on a corresponding surface of the grip ring within the body. A pipe is inserted through the nut, grip-ring, and seal into the body. Tightening of the nut causes its sloped surface to engage and the grip ring to be forced both radially and longitudinally. Radial compression results in the grip-ring engaging the pipe whilst longitudinal forcing causes it to be forced into the body simultaneously abutting against and compressing the seal whilst dragging the pipe further into the body. The nut and the body may further have tapered surfaces that are brought together as the grip-ring is forced into the body. The physical connection between the body and the nut provides reinforcing for the nut, a feature especially useful when dealing with soft plastics.

Abstract: Alpha substituted carboxylic acids of formula (I): wherein R1 and R2 are as defined in the specification and R3 is wherein Y, Ar1, Ar2, Ar3, R4, R5, R6, R7, R8, R9, R9a, R10, R11, R12, R17, ring A, and p are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR, specifically PPAR ?/? related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.

Abstract: Fused heteroarylcarboxylic acids of formula (I): 1

Abstract: A coupling assembly for plastic pipes including a nut, a body, a grip-ring, and a seal. The nut can engage the body through appropriate threads and includes a hooked projection having a sloping surface adapted to abut against and provide a force on a corresponding surface of the grip ring within the body. A pipe is inserted through the nut, grip-ring, and seal into the body. Tightening of the nut causes its sloped surface to engage and the grip ring to be forced both radially and longitudinally. Radial compression results in the grip-ring engaging the pipe whilst longitudinal forcing causes it to be forced into the body simultaneously abutting against and compressing the seal whilst dragging the pipe further into the body. The nut and the body may further have tapered surfaces that are brought together as the grip-ring is forced into the body. The physical connection between the body and the nut provides reinforcing for the nut, a feature especially useful when dealing with soft plastics.