Abstract: A chelator having the general structure (I) for chelating ra-diometals such as 225Ac under mild conditions is provided. (I) The chelator can be coupled to a biological targeting moiety to facilitate targeted delivery of the chelated radiometal in a mammalian subject.

Abstract: Apparatus worn by a person, methods, and support system for monitoring physiological parameters of the person, providing timely, actionable information to prevent death due to overdose, and, through social or professional influences, may cause life-saving changes in behavior. The apparatus sends alerts to the person via audible or tactile means, and to concerned others, that drug usage, drug overdose, or other critical medical condition has likely occurred. Alerts to concerned others include geographical information indicating where the person is, so that medical assistance personnel may find the person. Geographical information includes latitude, longitude, the translation of latitude and longitude into a street address, and elevation information indicating on which floor in a building the person is.