Abstract: The present disclosure concerns hydrogel compositions designed to occupy space within a cavity or space within a subject, as well as various additives or formulations thereof that allow the hydrogels to provide a therapeutic or physiological benefit to the subject in addition to the structural support provided.

Abstract: The present disclosure concerns hydrogel compositions designed to occupy space within a cavity or space within a subject, as well as various additives or formulations thereof that allow the hydrogels to provide a therapeutic or physiological benefit to the subject in addition to the structural support provided.

Abstract: The present disclosure concerns hydrogel compositions designed to occupy space within a cavity or space within a subject, as well as various additives or formulations thereof that allow the hydrogels to provide a therapeutic or physiological benefit to the subject in addition to the structural support provided.

Abstract: Catheters having an expanded configuration define a catheter lumen to provide fluid communication during fluid delivery. However, in between fluid delivery events, the catheter occupies a cross-sectional area within a vessel reducing the patency thereof and increasing the risk of occlusion formation. Embodiments include a catheter tube configured to collapse radially inward in between fluid delivery events to reduce the impact on the patency of the vessel and mitigate thrombosis formation. A fluid pressure within the catheter tube can transition the catheter to the expanded configuration. Catheter systems can further include an inflatable stiffening member configured to impart rigidity on the catheter tube to facilitate placement. Further, the catheter tube can include a reinforcement member configured to provide longitudinal strength while still allowing radial transition to the collapsed configuration.

Abstract: A medical sealant applicator device for delivery of a multi-component sealant including a first body having a base, a first syringe plunger, a second syringe plunger, and a longitudinal channel, laterally interposed between the first syringe plunger and the second syringe plunger. Each of the first syringe plunger and the second syringe plunger is oriented to extend in a first direction from the base. The first syringe plunger has a first free end having a first proximal plunger piston. The second syringe plunger having a second free end having a second proximal plunger piston. A second body of the medical sealant application device has a first syringe chamber, a second syringe chamber, and a longitudinal fluid chamber laterally interposed between the first syringe chamber and the second syringe chamber. The longitudinal fluid chamber has a proximal end and a distal end.

Abstract: Delivery devices, as well as systems incorporating the same and methods of using the same are disclosed. A needle assembly includes a hub having first and second input ports and an auxiliary port, and an injection needle assembly. The injection needle assembly includes an elongate hollow stylet extending distally from the hub that includes an outer side wall defining an outer lumen fluidly coupled to the auxiliary port, a first inner side wall defining a middle lumen disposed within the outer lumen that is fluidly coupled to the first input port, a second inner side wall defining an inner lumen disposed within the middle lumen that is fluidly coupled to the second input port, and a mixing chamber fluidly coupled to the outer lumen, the middle lumen, and the inner lumen.

Abstract: Sealant delivery systems, sealant applicators, and injection needle assemblies are disclosed. A sealant delivery system includes a sealant applicator that has two chambers separate from one another. Each chamber includes an output port on a distal end thereof. The sealant applicator also has a quarter turn connector disposed on a distal end of the sealant applicator adjacent to the output port of each chamber. The quarter turn connector is shaped to releasably interlock with a corresponding quarter turn connector of an injection needle assembly having input ports or a corresponding quarter turn connector of a dual chamber mixing syringe having mixing ports. When the injection needle assembly or the dual chamber mixing syringe is coupled to the sealant applicator via the quarter turn connector, the input ports or the mixing ports are aligned and sealed with the output port of each chamber of the sealant applicator.