Patents by Inventor Lung-Chi J. Yuan

Lung-Chi J. Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical formulations
    Patent number: 6635278
    Abstract: The invention provides compositions comprising the nucleotide analog 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and an alkaline excipient with or without L-carnitine-L-tartrate. The compositions are more stable those previously described. The invention also provides methods to make the compositions and their intermediates.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: October 21, 2003
    Assignee: Gilead Sciences, Inc.
    Inventors: Terrence C. Dahl, Lung-Chi J. Yuan
  • Composition and method for storing nucleotide analogs
    Patent number: 5763424
    Abstract: The invention provides compositions and methods to prevent the appearance of visually detectable precipitate in the composition upon storage of an aqueous solution of the composition containing 5-250 mg/mL of the phosphonate nucleotide analog for at least 6 months at 22.degree. where the composition comprises a phosphonate nucleotide analog and a sufficient amount of a divalent or trivalent metal cation sequestering agent such as about 0.1% w/v EDTA, and/or a sufficiently low concentration of a divalent or trivalent metal cation, e.g., about 3-10 ppm, and/or a sufficient pH in water, e.g., a pH of about 7.0-7.5.
    Type: Grant
    Filed: March 26, 1996
    Date of Patent: June 9, 1998
    Assignee: Gilead Sciences, Inc.
    Inventor: Lung-Chi J. Yuan