Patents by Inventor Lung-Huang Kuo

Lung-Huang Kuo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10072039
    Abstract: The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: September 11, 2018
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • Publication number: 20170145001
    Abstract: The present disclosure provides processes for preparing brexpiprazole. The present disclosure also provides processes for the purification of brexpiprazole. The processes for preparing and purifying brexpiprazole of the present invention provide substantial improvements over currently known methods. In certain embodiments, the conversion of Formula XI and XII to form XIII provides increased selectivity over previously reported methods. This offers increased yield and purity. The improved process for purifying brexpiprazole disclosed herein provides brexpiprazole with superior purity and is also more suitable for industrial production.
    Type: Application
    Filed: November 1, 2016
    Publication date: May 25, 2017
    Inventors: Chia-Ying LEE, Shu Ting HUANG, Hsin-Chi WANG, Yuan-Xiu LIAO, Jiunn-Cheh GUO, Lung-Huang KUO
  • Patent number: 9556218
    Abstract: The present invention provides intermediates for preparing abiraterone, and processes for preparing abiraterone and intermediates thereof. The intermediates include a compound of formula (IV): wherein R represents a hydroxy-protecting group.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: January 31, 2017
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Lung-Huang Kuo, Hsiao-Ping Fang, Ming-Feng Wu, Yu-Sheng Chang
  • Patent number: 9346844
    Abstract: The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5 In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: May 24, 2016
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • Publication number: 20150031865
    Abstract: The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5 In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Application
    Filed: July 25, 2013
    Publication date: January 29, 2015
    Applicant: Scinopharm Taiwan, LTD.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • Publication number: 20150031866
    Abstract: The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
    Type: Application
    Filed: July 25, 2013
    Publication date: January 29, 2015
    Applicant: Scinopharm Taiwan, LTD.
    Inventors: Lung-Huang Kuo, Shang-Hong Chen, Li-Ting Wang, Wen-Li Shih, Yuan-Xiu Liao
  • Publication number: 20150005489
    Abstract: The present invention provides intermediates for preparing abiraterone, and processes for preparing abiraterone and intermediates thereof. The intermediates include a compound of formula (IV): wherein R represents a hydroxy-protecting group.
    Type: Application
    Filed: June 26, 2014
    Publication date: January 1, 2015
    Inventors: Lung-Huang Kuo, Hsiao-Ping Fang, Ming-Feng Wu, Yu-Sheng Chang
  • Patent number: 6790977
    Abstract: A process for preparing 3,4-dihydroxybenzonitrile includes the steps of reacting a nitrile compound with an alkali metal halide, followed by treating with an acid.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: September 14, 2004
    Assignee: Sinon Corporation
    Inventors: Lung-Huang Kuo, Dei-She Ke, Chih-Da Lin, Shyh-Shyan Jwo, Wen-Hsin Chang
  • Publication number: 20040024239
    Abstract: A process for preparing 3,4-dihydroxybenzonitrile includes the steps of reacting a nitrile compound with an alkali metal halide, followed by treating with an acid.
    Type: Application
    Filed: July 30, 2002
    Publication date: February 5, 2004
    Inventors: Lung-Huang Kuo, Dei-She Ke, Chih-Da Lin, Shyh-Shyan Jwo, Wen-Hsin Chang
  • Publication number: 20020123655
    Abstract: A process for preparing alkoxy- and aryloxy-phenols involves the steps of reacting a benzaldehyde derivative with a peracid to form a benzodioxole derivative, removing non-reacted peracid from the reaction mixture, and reacting the benzodioxole derivative in the reaction mixture with a hydrolyzing agent.
    Type: Application
    Filed: February 20, 2001
    Publication date: September 5, 2002
    Applicant: SINON CORPORATION
    Inventors: Lung-Huang Kuo, Chih-Da Lin, Shyh-Shyan Jwo, Li-Ling Lin, Shou-Lun Lee, Shi-Jen Tsai
  • Patent number: 5973165
    Abstract: A process for preparing 2-oxindole includes catalytically reacting isatin with hydrazine hydrate in a polar solvent containing a dissolved weak base at an elevated temperature to form the 2-oxindole product.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: October 26, 1999
    Assignee: Sinon Corporation
    Inventors: Lung-Huang Kuo, Jaan-Pyng Hsu, Chin-Tsai Chen