Abstract: The present disclosure discloses a method for training a gearbox fault diagnosis model, and a gearbox fault diagnosis method. The method includes: acquiring a motor current signal in an electromechanical system where a gearbox is located; calculating, based on the current signal, characteristic values representing complexity and degree of mutation of the current signal; filtering the characteristic values based on a random forest algorithm to generate a sample data set; and training, based on the data set, a deep reinforcement learning network model to generate the fault diagnosis model. By means of the method for training the gearbox fault diagnosis model according to the present disclosure, merely the current signal is acquired, no additional sensor is needed, and the defect of additional hardware in the prior art is overcome.

Abstract: Provided are delayed sustained-release oral drug dosage forms comprising a Janus kinase (JAK) inhibitor, such as tofacitinib. In other aspects, provided are methods of designing, methods of making, such as using three-dimensional printing, and methods of treatment and/or prevention associated with the oral drug dosage forms described herein.

Abstract: A new approach is proposed that contemplates systems and methods to support safe preview and immediate delivery of a document from a document producer to an end user while protecting the user from accidentally opening the original document if it has been tampered with by an email attacker. First, the original document is submitted to a safe preview server cluster, where a passcode is generated for the document and the document is processed for policy assessments of possible security threats. The document is then encrypted with the generated passcode and provided to the user together with results of the policy assessments and a preview of content of the document for preview upon request. Based on the user's choice, the user can retrieve the passcode from the server and decrypt the document with the passcode wherein the original document is deleted from the safe preview server cluster once it is downloaded.

Abstract: A new approach is proposed that contemplates systems and methods to support bulk authentication of a device associated with a user to all cloud-based services the device intends to access in one transaction instead of authenticating the device against each of the services individually. First, the device generates and transmits to one or more authentication service clusters an authentication request that includes its identification and authentication credentials in order to access to a plurality of services. Upon receiving the authentication request, the authentication service cluster(s) authenticate the device for all of the services to be accessed based on the information in the authentication request. Once the device is authenticated, the authentication service cluster(s) then retrieve entitlement information of the services to be accessed by the device, and identify the service clusters/nodes that the device will connect to for the services with the fastest response time.

Abstract: A new approach is proposed that contemplates systems and methods to support bulk authentication of a device associated with a user to all cloud-based services the device intends to access in one transaction instead of authenticating the device against each of the services individually. First, the device generates and transmits to one or more authentication service clusters an authentication request that includes its identification and authentication credentials in order to access to a plurality of services. Upon receiving the authentication request, the authentication service cluster(s) authenticate the device for all of the services to be accessed based on the information in the authentication request. Once the device is authenticated, the authentication service cluster(s) then retrieve entitlement information of the services to be accessed by the device, and identify the service clusters/nodes that the device will connect to for the services with the fastest response time.

Abstract: A new approach is proposed that contemplates systems and methods to support bulk authentication of an appliance associated with a user to all cloud-based services the appliance intends to access in one transaction instead of authenticating the appliance against each of the services individually. First, the appliance generates and transmits to an authentication service cluster an authentication request that includes its identification and authentication credentials in order to access to a plurality of services. Upon receiving the authentication request, the authentication service cluster authenticates the appliance for all of the services to be accessed based on the information in the authentication request. Once the appliance is authenticated, the authentication service cluster then retrieves entitlement information of the services to be accessed by the appliance, and identifies the service clusters/nodes that the appliance will connect to for the services with the fastest response time.

Abstract: A new approach is proposed that contemplates systems and methods to support bulk authentication of an appliance associated with a user to all cloud-based services the appliance intends to access in one transaction instead of authenticating the appliance against each of the services individually. First, the appliance generates and transmits to an authentication service cluster an authentication request that includes its identification and authentication credentials in order to access to a plurality of services. Upon receiving the authentication request, the authentication service cluster authenticates the appliance for all of the services to be accessed based on the information in the authentication request. Once the appliance is authenticated, the authentication service cluster then retrieves entitlement information of the services to be accessed by the appliance, and identifies the service clusters/nodes that the appliance will connect to for the services with the fastest response time.

Abstract: The present invention provides isolated nucleic acids encoding delta DNA methyltransferase 3B molecules that are involved in the treatment and prevention of cancers such as, but not limited to, lung cancer. The delta DNA methyltransferase 3B molecules of the present invention are found to play a critical role in promoter-specific methylation of tumor suppressor genes. The DNA methyltransferase 3B molecules of the present invention are provided as therapeutic targets for identifying inhibitors of DNA methyltransferase. Such inhibitors are contemplated for the treatment and/or prevention of cancers. In particular embodiments, the present invention involves the treatment and prevention of a non-small cell lung cancer.

Abstract: The present invention provides isolated nucleic acids encoding delta DNA methyltransferase 3B molecules that are involved in the treatment and prevention of cancers such as, but not limited to, lung cancer. The delta DNA methyltransferase 3B molecules of the present invention are found to play a critical role in promoter-specific methylation of tumor suppressor genes. The DNA methyltransferase 3B molecules of the present invention are provided as therapeutic targets for identifying inhibitors of DNA methyltransferase. Such inhibitors are contemplated for the treatment and/or prevention of cancers. In particular embodiments, the present invention involves the treatment and prevention of a non-small cell lung cancer.

Abstract: A method and system for querying multiple career websites from a single interface is disclosed, where each of the websites comprises a plurality of web pages having site-specific fields requiring input of data. The method and system include collecting information from a user, and mapping the user information to the site-specific fields of each of the career websites. The method and system further include automatically filling-in the site-specific fields of each of the career websites with the mapped user information, and forming respective query strings from the filled-in site-specific fields for each of the career websites. The respective query strings are then submitted to the corresponding career websites.

Abstract: A method and system for querying multiple career websites from a single interface is disclosed, where each of the websites comprises a plurality of web pages having site-specific fields requiring input of data. The method and system include collecting information from a user, and mapping the user information to the site-specific fields of each of the career websites. The method and system further include automatically filling-in the site-specific fields of each of the career websites with the mapped user information, and forming respective query strings from the filled-in site-specific fields for each of the career websites. The respective query strings are then submitted to the corresponding career websites.

Abstract: A method and system for querying multiple career websites from a single interface is disclosed, where each of the websites comprises a plurality of web pages having site-specific fields requiring input of data. The method and system include collecting information from a user, and mapping the user information to the site-specific fields of each of the career websites. The method and system further include automatically filling-in the site-specific fields of each of the career websites with the mapped user information, and forming respective query strings from the filled-in site-specific fields for each of the career websites. The respective query strings are then submitted to the corresponding career websites.