Patents by Inventor Lutske Aafke Anna de Jong

Lutske Aafke Anna de Jong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the determination of an analyte comprising a primary amino group, and kit for labeling said analyte
    Patent number: 8323979
    Abstract: The invention provides a method for labeling an analyte comprising a primary amino group, the method comprising: a. a labeling process comprising reacting the analyte with a dialdehyde in the presence of a label, wherein the label bears a charge, and b. an analysis process comprising subjecting the labeled analyte to MS, preferably LC-MS-MS. Herein, preferably, the labeling process comprises reacting an analyte with a dialdehyde, wherein the dialdehyde carries a label bearing a charge, to provide a labeled analyte carrying the charge. The present invention also provides a labeling method to provide a labeled analyte carrying a charge, wherein the labeling method comprises a labeling process comprising reacting an analyte with a dialdehyde, wherein the analyte comprises a primary amino group and wherein the dialdehyde carries a label bearing the charge. The dialdehyde is preferably an aromatic dialdehyde, most preferably an aromatic 1,2- or 1,3-dicarboxaldehyde.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: December 4, 2012
    Assignee: Brains Online Holding B.V.
    Inventors: Thomas Ivo Franciscus Hubert Cremers, Lutske Aafke Anna de Jong, Wijnand Sjoerd Faber
  • Method for the determination of an analyte comprising a primary amino group, and kit for labeling said analyte
    Publication number: 20100184231
    Abstract: The invention provides a method for labeling an analyte comprising a primary amino group, the method comprising: a. a labeling process comprising reacting the analyte with a dialdehyde in the presence of a label, wherein the label bears a charge, and b. an analysis process comprising subjecting the labeled analyte to MS, preferably LC-MS-MS. Herein, preferably, the labeling process comprises reacting an analyte with a dialdehyde, wherein the dialdehyde carries a label bearing a charge, to provide a labeled analyte carrying the charge. The present invention also provides a labeling method to provide a labeled analyte carrying a charge, wherein the labeling method comprises a labeling process comprising reacting an analyte with a dialdehyde, wherein the analyte comprises a primary amino group and wherein the dialdehyde carries a label bearing the charge. The dialdehyde is preferably an aromatic dialdehyde, most preferably an aromatic 1,2- or 1,3-dicarboxaldehyde.
    Type: Application
    Filed: March 19, 2008
    Publication date: July 22, 2010
    Inventors: Thomas Ivo Franciscus Huber Cremers, Lutske Aafke Anna de Jong, Wijnand Sjoerd Faber