Abstract: The present invention relates to 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one for use in the treatment of spinal muscular atrophy (SMA), its pharmaceutical composition to be used in the treatment of SMA, its methods of treatment thereof.

Abstract: The present invention relates to 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one for use in the treatment of spinal muscular atrophy (SMA), its pharmaceutical composition to be used in the treatment of SMA, its methods of treatment thereof.

Abstract: A method for controlling an automated starter clutch (4) in a drive train of a motor vehicle (1), which drive train has a transmission (3). In at least one first mode, the starter clutch (4) is operated automatically and is transitioned in an event-controlled manner into a second mode, in which the starter clutch (4) can be operated in such a way that upon actuation of the starter clutch (4), at least one jolt-like movement of the motor vehicle (1) is caused. In the second mode, the actuation of the starter clutch (4) is initiated and controlled depending upon operation of an accelerator pedal (13).

Abstract: A micromechanical switch including a first substrate with a micromechanical functional layer in which a deflectable switching element is formed, and with a second substrate that is connected to the first substrate. The second substrate is situated at a distance above the switching element. The switching element includes an electrically conductive first contact area and is deflectable toward the second substrate. The second substrate, at an internal side, includes an electrically conductive second contact area that is situated in such a way that the switching element together with the first contact area may be applied to the second contact area in order to close an electrical contact. A method for manufacturing a micromechanical switch is also described.

Abstract: The present disclosure relates to scintillating detector systems for radiation therapy beams. In one implementation, a detector system for evaluating radiation delivered by a radiation beam output from a beam generator may include a phantom enclosing an internal volume and having an outer surface, extending around the internal volume, for exposure to radiation, and an inner surface coated, at least in part, with a scintillating material and facing the internal volume. The system may further include a camera external to the enclosed volume and configured to view at least a portion of the inner surface, through an opening of the hollow phantom, when radiated by the radiation beam. The system may further include at least one processor configured to receive images from the camera and calculate, based on the received images, a spatial dose distribution produced by the radiation delivered by the radiation beam to the hollow phantom.

Abstract: A quick-change system includes an exchange tool with a ball receiving opening, a receiving part with a receiving opening for receiving the exchange tool, and a ball catch for temporarily fixing the exchange tool on the receiving part. The ball catch includes a sleeve that is closed on one side and a spring-mounted press-ball arranged in the sleeve for manually engaging and disengaging with the ball-receiving opening. In an example embodiment, the sleeve has an axis of symmetry, the spring-mounted press-ball is movable along the axis of symmetry, and the ball-receiving opening has a central axis extending parallel to the axis of symmetry when the receiving part is engaged with the exchange tool.

Abstract: A method for controlling an automated starter clutch (4) in a drive train of a motor vehicle (1), which drive train has a transmission (3). In at least one first mode, the starter clutch (4) is operated automatically and is transitioned in an event-controlled manner into a second mode, in which the starter clutch (4) can be operated in such a way that upon actuation of the starter clutch (4), at least one jolt-like movement of the motor vehicle (1) is caused. In the second mode, the actuation of the starter clutch (4) is initiated and controlled depending upon operation of an accelerator pedal (13).

Abstract: The present disclosure relates to scintillating detector systems for radiation therapy beams. In one implementation, a detector system for evaluating radiation delivered by a radiation beam output from a beam generator may include a phantom enclosing an internal volume and having an outer surface, extending around the internal volume, for exposure to radiation, and an inner surface coated, at least in part, with a scintillating material and facing the internal volume. The system may further include a camera external to the enclosed volume and configured to view at least a portion of the inner surface, through an opening of the hollow phantom, when radiated by the radiation beam. The system may further include at least one processor configured to receive images from the camera and calculate, based on the received images, a spatial dose distribution produced by the radiation delivered by the radiation beam to the hollow phantom.

Abstract: The present invention relates to 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one for use in the treatment of spinal muscular atrophy (SMA), its pharmaceutical composition to be used in the treatment of SMA, its methods of treatment thereof.

Abstract: A sensing device for a radiation therapy apparatus, the apparatus comprising an accelerator and a beam-shaping device the beam shaping device being a multi-leaf collimator (MLC) (2) having a plurality of pairs of leaves, and a rotatable gantry, the sensing device comprising: a transmission electronic detector (1) comprising an array of ionization chambers. The ionization chambers are defined by a bias electrode (11a,11b, 34,42) on the one hand and by a planar array of conductive strips (40) or strip assemblies (30) on the other hand. The strips or strip assemblies are associated to the leaf pairs of the MLC. The strips are the collecting electrodes of the ionization chambers.

Abstract: A sensing device for a radiation therapy apparatus, the apparatus comprising an accelerator and a beam-shaping device the beam shaping device being a multi-leaf collimator (MLC) (2) having a plurality of pairs of leaves, and a rotatable gantry, the sensing device comprising: a transmission electronic detector (1) comprising an array of ionization chambers. The ionization chambers are defined by a bias electrode (11a,11b, 34,42) on the one hand and by a planar array of conductive strips (40) or strip assemblies (30) on the other hand. The strips or strip assemblies are associated to the leaf pairs of the MLC. The strips are the collecting electrodes of the ionization chambers.

Abstract: A method for starting up an automation machine in a machine series is described. With the method, a software package is automatically generated in a planning system with a step tree. The step tree included in the software package is structured in the form of a graph with edges and nodes, wherein at least some of the nodes comprise start-up data or start-up information relating to the start-up data, and wherein the edges describe permitted transitions between two respective nodes. The software package is executed on a machine or on a unit which is connected with the machine for communication. A planning system for carrying out the method is also disclosed.

Abstract: A micromechanical structure, in particular a micromechanical electric field meter as a thunderstorm warning device, for detection of an electric field, comprising a substrate having a principal extension plane, a first electrode, a second electrode, and a drive assemblage for producing a relative motion of the second electrode with respect to the first electrode into an overlapping position, the first electrode and the second electrode being, in the overlapping position, disposed above one another in a projection direction extending perpendicularly to the principal extension plane of the substrate, wherein the second electrode has a defined potential for shielding the first electrode with respect to the electric field in the overlapping position.

Abstract: The invention relates to an electronic component (1) having a corrosion-protected bonding connection and a method for producing said component. For this purpose the electronic component (1) has at least one semiconductor chip (3) on a substrate (4). Moreover, a bonding connection at risk of corrosion is provided on the semiconductor chip (3). For encapsulation of the at least one semiconductor chip (3) and the at least one bonding connection at risk of corrosion, said semiconductor chip and bonding connection are surrounded by a hermetically sealing housing (5). The hermetically sealed bonding connection is a bonding wire connection (2) which is fully enclosed in the housing (5), in which the substrate (4) is at least partially enclosed. The substrate (4) has at least one surface-mounted hydrolysis-sensitive component (6) in the housing (5).

Abstract: A storage battery module includes at least one storage battery cell and a shell enclosing the storage battery cell, the shell including fibers, and spaces remaining between the fibers.

Abstract: The invention relates to an electronic component (1) having a corrosion-protected bonding connection and a method for producing said component. For this purpose the electronic component (1) has at least one semiconductor chip (3) on a substrate (4). Moreover, a bonding connection at risk of corrosion is provided on the semiconductor chip (3). For encapsulation of the at least one semiconductor chip (3) and the at least one bonding connection at risk of corrosion, said semiconductor chip and bonding connection are surrounded by a hermetically sealing housing (5). The hermetically sealed bonding connection is a bonding wire connection (2) which is fully enclosed in the housing (5), in which the substrate (4) is at least partially enclosed. The substrate (4) has at least one surface-mounted hydrolysis-sensitive component (6) in the housing (5).

Abstract: A micromechanical structure, in particular a micromechanical electric field meter as a thunderstorm warning device, for detection of an electric field, comprising a substrate having a principal extension plane, a first electrode, a second electrode, and a drive assemblage for producing a relative motion of the second electrode with respect to the first electrode into an overlapping position, the first electrode and the second electrode being, in the overlapping position, disposed above one another in a projection direction extending perpendicularly to the principal extension plane of the substrate, wherein the second electrode has a defined potential for shielding the first electrode with respect to the electric field in the overlapping position.

Abstract: A drug delivery device for dispensing of a dose of a medicinal product is presented comprising a first housing component having a receptacle being oval- or elliptically shaped in radial cross section and being adapted to at least partially receive an insert portion of a second housing component being at least partially insertable into said first housing component along an axial direction, wherein the insert portion is oval- or elliptically shaped in radial cross section. The outside dimension or an at least one outside diameter of the insert portion is at least in sections larger than a corresponding inner dimension or an at least one inner diameter of the receptacle and wherein the insert portion and the receptacle are adapted to generate a radially acting mutual clamping of first and second housing components in a pre-fixing assembly configuration.

Abstract: A method of controlling and/or regulating an automated transmission of a vehicle in which a rolling function or a coasting function of the vehicle is activated in an automatic mode, under predetermined conditions, such that the drivetrain is disengaged and the drive motor is one of operated at idle or is switched off at times. The rolling function or the coasting function is automatically terminated if at least one of the predetermined conditions is no longer present. The rolling function or the coasting function can also be terminated manually by the driver, and a manually operable shifting strategy can be initiated.

Abstract: The present invention relates to a drug delivery device for dispensing of a dose of a medicinal product, comprising: a first housing component (12, 52; 62) adapted to receive a cartridge (16) comprising the medicinal product and further comprising a piston (18) slidably arranged therein in an axial direction, a second housing component (14; 54; 64) adapted to receive a dose dispensing mechanism having a piston rod (20) to be operably engaged with the cartridge's piston (18), wherein the first and the second housing components (12, 14; 52, 54; 62, 64) are displaceably arranged in axial direction relative to each other for reducing an axial distance (34) between the piston (18) and the piston rod (20) to a pre-defined degree, and an interlock means (30) adapted to interact with at least one of first and second housing components (12, 14; 52, 54; 62, 64) for mutually locking into position first and second housing components (12, 14; 52, 54; 62, 64).