Patents by Inventor Lutz Riechmann
Lutz Riechmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9670482Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.Type: GrantFiled: November 26, 2013Date of Patent: June 6, 2017Assignee: BICYCLE THERAPEUTICS LIMITEDInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
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Publication number: 20140163201Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.Type: ApplicationFiled: November 26, 2013Publication date: June 12, 2014Applicant: BICYCLE THERAPEUTICS LIMITEDInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
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Patent number: 8685890Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.Type: GrantFiled: February 4, 2010Date of Patent: April 1, 2014Assignee: Bicycle Therapeutics LimitedInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
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Patent number: 8338107Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: GrantFiled: November 16, 2006Date of Patent: December 25, 2012Assignees: Scripps Research Institute, Medical Research Institute, Catalyst Assets LLCInventors: William D. Huse, Gregory P. Winter, Lutz Riechmann, Joseph A. Sorge, Richard A. Lerner
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Publication number: 20120101256Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.Type: ApplicationFiled: February 4, 2010Publication date: April 26, 2012Applicant: Medical Research CouncilInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
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Patent number: 7858359Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: GrantFiled: November 9, 2006Date of Patent: December 28, 2010Assignees: Stratagene, Medical Research CouncilInventors: William D. Huse, Gregory P. Winter, Lutz Riechmann, Joseph A. Sorge, Richard A. Lerner
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Patent number: 7442159Abstract: The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein said virus comprises a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; (c) propagating the virus comprising intact fusion protein.Type: GrantFiled: November 10, 2000Date of Patent: October 28, 2008Assignee: Domantis LimitedInventors: Lutz Riechmann, Peter Kristensen, Jean-Luc Jestin, Gregory Paul Winter
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Publication number: 20080004434Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: ApplicationFiled: November 9, 2006Publication date: January 3, 2008Applicant: StratageneInventors: William Huse, Gregory Winter, Lutz Riechmann, Joseph Sorge, Richard Lerner
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Publication number: 20070207475Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: ApplicationFiled: November 16, 2006Publication date: September 6, 2007Applicants: Scripps Research Institute, Medical Research Council, StratageneInventors: William Huse, Gregory Winter, Lutz Riechmann, Joseph Sorge, Richard Lerner
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Patent number: 7189841Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: GrantFiled: August 2, 2004Date of Patent: March 13, 2007Assignees: Scripps Research Institute, Medical Research Council, StratageneInventors: Richard A. Lerner, Joseph A. Sorge, Gregory P. Winter, Lutz Riechmann
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Publication number: 20060019260Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: ApplicationFiled: August 2, 2004Publication date: January 26, 2006Inventors: Richard Lerner, Joseph Sorge, Gregory Winter, Lutz Riechmann
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Patent number: 6969586Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: GrantFiled: November 28, 2000Date of Patent: November 29, 2005Assignees: Scripps Research Institute, Medical Research Council, StratageneInventors: Richard A. Lerner, Joseph A. Sorge, Gregory P. Winter, Lutz Riechmann
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Patent number: 6569430Abstract: An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.Type: GrantFiled: March 21, 1995Date of Patent: May 27, 2003Assignee: BTG International LimitedInventors: Herman Waldmann, Michael R. Clark, Gregory P. Winter, Lutz Riechmann
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Publication number: 20030078192Abstract: The invention relates to a pharmaceutical composition comprising a chimeric, folded protein domain comprising two or more sequence segments from parent amino acid sequences that are not homologous. The invention more particularly relates to compositions comprising a chimeric, folded protein domain comprising two or more sequence segments wherein each of the sequence segments: is not designed or selected to consist solely of a single complete protein structural element and is not designed or selected to consist solely of an entire protein domain; and, in isolation, shows no significant folding at the melting temperature of the chimeric protein. The invention also relates to methods for the selection of such protein domains, and to methods of raising an immune response using such domains, and preferably to chimeric domains that display conformational B cell epitopes of at least one of their parent amino acid sequences.Type: ApplicationFiled: April 10, 2002Publication date: April 24, 2003Inventors: Gregory Paul Winter, Lutz Riechmann
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Patent number: 6291159Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: GrantFiled: August 21, 1992Date of Patent: September 18, 2001Assignees: Scripps Research Institute, Medical Research Council, StratageneInventors: Gregory P. Winter, Lutz Riechmann, William D. Huse, Joseph A. Sorge, Richard A. Lerner
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Patent number: 6291158Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: GrantFiled: August 21, 1992Date of Patent: September 18, 2001Assignees: Scripps Research Institute, Medical Research Council, StratageneInventors: Gregory P. Winter, Lutz Riechmann, William D. Huse, Joseph A. Sorge, Richard A. Lerner
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Patent number: 6291161Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.Type: GrantFiled: September 4, 1992Date of Patent: September 18, 2001Assignees: Scripps Research Institute, Medical Research Council, StratageneInventors: Richard A. Lerner, Joseph A. Sorge, Gregory P. Winter, Lutz Riechmann
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Patent number: 5965405Abstract: Methods for preparing Fv fragments which lack linking polypeptides in eukaryotic cells are provided.Type: GrantFiled: December 13, 1993Date of Patent: October 12, 1999Assignee: Celltech LimitedInventors: Gregory Paul Winter, Lutz Riechmann, Geoffrey Thomas Yarranton, Mark William Bodmer, Raymond John Owens
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Patent number: 5846534Abstract: An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.Type: GrantFiled: April 29, 1994Date of Patent: December 8, 1998Assignee: British Technology Group LimitedInventors: Herman Waldmann, Michael R. Clark, Gregory P. Winter, Lutz Riechmann