Patents by Inventor Lutz Riechmann

Lutz Riechmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9670482
    Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: June 6, 2017
    Assignee: BICYCLE THERAPEUTICS LIMITED
    Inventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
  • Publication number: 20140163201
    Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.
    Type: Application
    Filed: November 26, 2013
    Publication date: June 12, 2014
    Applicant: BICYCLE THERAPEUTICS LIMITED
    Inventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
  • Patent number: 8685890
    Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: April 1, 2014
    Assignee: Bicycle Therapeutics Limited
    Inventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
  • Patent number: 8338107
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: December 25, 2012
    Assignees: Scripps Research Institute, Medical Research Institute, Catalyst Assets LLC
    Inventors: William D. Huse, Gregory P. Winter, Lutz Riechmann, Joseph A. Sorge, Richard A. Lerner
  • Publication number: 20120101256
    Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.
    Type: Application
    Filed: February 4, 2010
    Publication date: April 26, 2012
    Applicant: Medical Research Council
    Inventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
  • Patent number: 7858359
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: December 28, 2010
    Assignees: Stratagene, Medical Research Council
    Inventors: William D. Huse, Gregory P. Winter, Lutz Riechmann, Joseph A. Sorge, Richard A. Lerner
  • Patent number: 7442159
    Abstract: The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein said virus comprises a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; (c) propagating the virus comprising intact fusion protein.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: October 28, 2008
    Assignee: Domantis Limited
    Inventors: Lutz Riechmann, Peter Kristensen, Jean-Luc Jestin, Gregory Paul Winter
  • Publication number: 20080004434
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Application
    Filed: November 9, 2006
    Publication date: January 3, 2008
    Applicant: Stratagene
    Inventors: William Huse, Gregory Winter, Lutz Riechmann, Joseph Sorge, Richard Lerner
  • Publication number: 20070207475
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Application
    Filed: November 16, 2006
    Publication date: September 6, 2007
    Applicants: Scripps Research Institute, Medical Research Council, Stratagene
    Inventors: William Huse, Gregory Winter, Lutz Riechmann, Joseph Sorge, Richard Lerner
  • Patent number: 7189841
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: March 13, 2007
    Assignees: Scripps Research Institute, Medical Research Council, Stratagene
    Inventors: Richard A. Lerner, Joseph A. Sorge, Gregory P. Winter, Lutz Riechmann
  • Publication number: 20060019260
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Application
    Filed: August 2, 2004
    Publication date: January 26, 2006
    Inventors: Richard Lerner, Joseph Sorge, Gregory Winter, Lutz Riechmann
  • Patent number: 6969586
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: November 29, 2005
    Assignees: Scripps Research Institute, Medical Research Council, Stratagene
    Inventors: Richard A. Lerner, Joseph A. Sorge, Gregory P. Winter, Lutz Riechmann
  • Patent number: 6569430
    Abstract: An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: May 27, 2003
    Assignee: BTG International Limited
    Inventors: Herman Waldmann, Michael R. Clark, Gregory P. Winter, Lutz Riechmann
  • Publication number: 20030078192
    Abstract: The invention relates to a pharmaceutical composition comprising a chimeric, folded protein domain comprising two or more sequence segments from parent amino acid sequences that are not homologous. The invention more particularly relates to compositions comprising a chimeric, folded protein domain comprising two or more sequence segments wherein each of the sequence segments: is not designed or selected to consist solely of a single complete protein structural element and is not designed or selected to consist solely of an entire protein domain; and, in isolation, shows no significant folding at the melting temperature of the chimeric protein. The invention also relates to methods for the selection of such protein domains, and to methods of raising an immune response using such domains, and preferably to chimeric domains that display conformational B cell epitopes of at least one of their parent amino acid sequences.
    Type: Application
    Filed: April 10, 2002
    Publication date: April 24, 2003
    Inventors: Gregory Paul Winter, Lutz Riechmann
  • Patent number: 6291161
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Grant
    Filed: September 4, 1992
    Date of Patent: September 18, 2001
    Assignees: Scripps Research Institute, Medical Research Council, Stratagene
    Inventors: Richard A. Lerner, Joseph A. Sorge, Gregory P. Winter, Lutz Riechmann
  • Patent number: 6291158
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Grant
    Filed: August 21, 1992
    Date of Patent: September 18, 2001
    Assignees: Scripps Research Institute, Medical Research Council, Stratagene
    Inventors: Gregory P. Winter, Lutz Riechmann, William D. Huse, Joseph A. Sorge, Richard A. Lerner
  • Patent number: 6291159
    Abstract: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
    Type: Grant
    Filed: August 21, 1992
    Date of Patent: September 18, 2001
    Assignees: Scripps Research Institute, Medical Research Council, Stratagene
    Inventors: Gregory P. Winter, Lutz Riechmann, William D. Huse, Joseph A. Sorge, Richard A. Lerner
  • Patent number: 5965405
    Abstract: Methods for preparing Fv fragments which lack linking polypeptides in eukaryotic cells are provided.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: October 12, 1999
    Assignee: Celltech Limited
    Inventors: Gregory Paul Winter, Lutz Riechmann, Geoffrey Thomas Yarranton, Mark William Bodmer, Raymond John Owens
  • Patent number: 5846534
    Abstract: An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: December 8, 1998
    Assignee: British Technology Group Limited
    Inventors: Herman Waldmann, Michael R. Clark, Gregory P. Winter, Lutz Riechmann