Abstract: A window-guiding and sealing assembly for use particularly in a door of a passenger-type automotive vehicle having a window frame comprises a guide member directly attached to the window along a substantially vertical edge thereof and projecting into the interior of the vehicle, this guide member being slidably mounted in a vertical guide rail on the vehicle body. A hollow substantially oval sealing strip is integrally formed with a holder having a resilient clip for forming a snap-lock engagement with a flange and a recess along the members of the window frame, the holder having a guide surface on a horizontal portion for facilitating the engagement of an upper part of the window pane and a horizontal section of the sealing strip upon a closing of the window assembly. The holder is further provided along its entire length with an inwardly facing shoulder for engaging another hollow sealing strip attached to the door frame.