Abstract: A system is provided for determining when supplemental content unresponsive to a user input is to be presented during a user interaction. The system determines an action, performance of which, may trigger output of supplemental content. The system may determine when, during a user interaction corresponding to performance of the action, supplemental content may be presented. The system may use constraint data indicating a device type via which the content may be presented, and a time duration during which the supplemental content may be presented. If the constraint data is satisfied, the system may determine to present the supplemental content.

Abstract: Described herein are isolated nucleic acid molecules comprising nucleotide sequence encoding mannose receptor, C type 1 (MRC1) wherein the 5? region of the nucleotide sequence encoding MRC1 is codon optimized; cells comprising such nucleic acid molecules; and methods of detecting antibody production, e.g., neutralizing antibody production, in a subject being treated for Gaucher disease using such cells.