Abstract: The present invention relates to the technical field of biological medicine, and particularly to a heat shock protein 90 (HSP90)-mediated targeting chimera (HEMTAC) small-molecule degradation agent and an application thereof. It is found through research in the present invention that the HEMTAC small-molecule degradation agent can induce formation of an HSP90-HEMTAC-targeted protein ternary complex, the targeted protein is spatially positioned at a position which is beneficial for being mistakenly recognized as an “abnormal” protein by the HSP90, is then introduced into a ubiquitin-proteasome system, and causes degradation of the targeted protein. HEMTACs are released to participate in the next degradation cycle. Therefore, the HEMTACs have a catalytic effect in targeted protein ubiquitin induction and degradation, can be used for treating diseases related to tumors, inflammations, immunity and the like, and have a good prospect for practical application.

Abstract: The present invention provides a chroman compound of formula (I) and its pharmaceutical salt, methods of its preparation and its pharmaceutical applications. Wherein: X is O or S; n is for 2, 3 or 4; R1 is 6-substituted or 7-substituted halogen, C1-4alkyl, C1-4alkoxyl, benzyloxy, carbamoyl; R2 is nitrogen-containing five-membered or six-membered substituted heterocyclic ring selected from piperidinyl, morpholinyl, N-methyl-piperazinyl, N-(2-ethoxyl)piperazinyl, pyrrolyl, pyrazolyl or imidazolyl. The compounds are useful to prepare medicaments for treating cardiovascular diseases, their preparation employs mild reaction conditions, the raw material are plenty and easy to be obtained, and the operation and post-treatment in the preparation are simple.

Abstract: The present invention provided a chroman compound, the method of its preparation and pharmaceutical applications. The compound are represented by formula (I) and its pharmaceutical salt, where in :x is for O or S; n is for 2, 3 or 4; R1 is 6-situ or 7-situ halogen, C1-4alkyl, C1-4alkyoxyl, benzyloxy, acylamino; R2 is nitrogen-containing pentatomic or hexahydric substituted heterocyclic ring. The compound is useful to prepare anti-arrhythmic drugs, the reaction conditions of the method are mild, the raw material are plenty and easy to be obtained, and the operation and post-treatment are simple.