Patents by Inventor Ly James Lee

Ly James Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10705085
    Abstract: Disclosed are compositions and methods for the use of lipoplex nanoparticle chips and arrays in the detection of/diagnosis of a disease or condition.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: July 7, 2020
    Assignee: Ohio State Innovation Foundation
    Inventors: Ly James Lee, Kwang Joo Kwak, Bo Yu, Yun Wu, Andrew Lee
  • Publication number: 20200115425
    Abstract: Disclosed herein are compositions and methods for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.
    Type: Application
    Filed: December 20, 2017
    Publication date: April 16, 2020
    Inventors: Daniel Gallego-Perez, Ly James Lee, Durba Pal, Subhadip Ghatak, Chandan Sen
  • Patent number: 10538640
    Abstract: Polymer foam and a method for preparing the same are disclosed. In the present disclosure, the method sequentially comprises the following steps: providing a polymer body; performing a pressure-induced flow (PIF) process on the polymer body at a first predetermined temperature and a first predetermined pressure for a pressure holding time, to obtain a polymer sheet; and performing a foaming process on the polymer sheet by using a foaming agent at a second predetermined temperature and a second predetermined pressure for a saturation time, to obtain polymer foam.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: January 21, 2020
    Assignees: LCY CHEMICAL CORP., OHIO STATE INNOVATION FOUNDATION
    Inventors: Ly James Lee, Dachao Li, Ying-Chieh Yen, Dajiong Fu, Yuen-Yuen D Chiu, Chiang-Hsiang Lin
  • Patent number: 10100300
    Abstract: A simple and low cost method of producing sealed arrays of laterally ordered nanochannels interconnected to microchannels of tunable size, over large surface areas, is disclosed. The method incorporates DNA combing and subsequent imprinting. Associated micro and macroscale inlets and outlets can be formed in the same process or manufactured later in low cost, non-cleanroom techniques. The techniques embrace two procedures, generating DNA nanostrands and translating these strands into nanoscale constructs via imprinting. Devices incorporating the novel arrays have a first microchannel, a second microchannel and a nanochannel that is substantially linear and which defines an axis. The nanochannel is connected at its open ends to the microchannels, which are aligned along the axis. Methods for precise dose delivery of agents into cells employing the devices in nanoelectroporation methods are also disclosed.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: October 16, 2018
    Inventors: Ly James Lee, Pouyan E. Boukany, Jingjiao Guan, Nan-Rong Chiou
  • Publication number: 20180179577
    Abstract: The present invention provides a novel lipid-polymer hybrid nanoparticle (LPHN) biochip. The LPHN biochip comprises a gold coating substrate with a surface layer on the gold coating and a nanoparticle, wherein the nanoparticle anchors on the surface layer and encapsulates labeling moieties which comprise molecular beacons (MB), Toehold-initiated molecular beacons (Ti-MB), biomolecules or components for performing catalyzed hairpin DNA circuit (CHDC), and quantum dots. A method of detecting the presence of a disease or condition in a subject by the lipid-polymer hybrid nanoparticle biochip is also disclosed in the specification.
    Type: Application
    Filed: December 5, 2017
    Publication date: June 28, 2018
    Inventors: Jiaming Hu, Yan Sheng, Ly James Lee
  • Publication number: 20180127739
    Abstract: A simple and low cost method of producing sealed arrays of laterally ordered nanochannels interconnected to microchannels of tunable size, over large surface areas, is disclosed. The method incorporates DNA combing and subsequent imprinting. Associated micro and macroscale inlets and outlets can be formed in the same process or manufactured later in low cost, non-cleanroom techniques. The techniques embrace two procedures, generating DNA nanostrands and translating these strands into nanoscale constructs via imprinting. Devices incorporating the novel arrays have a first microchannel, a second microchannel and a nanochannel that is substantially linear and which defines an axis. The nanochannel is connected at its open ends to the microchannels, which are aligned along the axis. Methods for precise dose delivery of agents into cells employing the devices in nanoelectroporation methods are also disclosed.
    Type: Application
    Filed: November 10, 2017
    Publication date: May 10, 2018
    Inventors: Ly James Lee, Pouyan E. Boukany, Jingjiao Guan, Nan-Rong Chiou
  • Publication number: 20170328904
    Abstract: Disclosed are compositions and methods for the use of lipoplex nanoparticle chips and arrays in the detection of/diagnosis of a disease or condition.
    Type: Application
    Filed: September 29, 2016
    Publication date: November 16, 2017
    Inventors: Ly James Lee, Kwang Joo Kwak, Bo Yu, Yun Wu, Andrew Lee
  • Patent number: 9816086
    Abstract: A simple and low cost method of producing sealed arrays of laterally ordered nanochannels interconnected to microchannels of tunable size, over large surface areas, is disclosed. The method incorporates DNA combing and subsequent imprinting. Associated micro and macroscale inlets and outlets can be formed in the same process or manufactured later in low cost, non-cleanroom techniques. The techniques embrace two procedures, generating DNA nanostrands and translating these strands into nanoscale constructs via imprinting. Devices incorporating the novel arrays have a first microchannel, a second microchannel and a nanochannel that is substantially linear and which defines an axis. The nanochannel is connected at its open ends to the microchannels, which are aligned along the axis. Methods for precise dose delivery of agents into cells employing the devices in nanoelectroporation methods are also disclosed.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: November 14, 2017
    Inventors: Ly James Lee, Pouyan E. Boukany, Jingjiao Guan, Nan-Rong Chiou
  • Publication number: 20170029589
    Abstract: Polymer foam and a method for preparing the same are disclosed. In the present disclosure, the method sequentially comprises the following steps: providing a polymer body; performing a pressure-induced flow (PIF) process on the polymer body at a first predetermined temperature and a first predetermined pressure for a pressure holding time, to obtain a polymer sheet; and performing a foaming process on the polymer sheet by using a foaming agent at a second predetermined temperature and a second predetermined pressure for a saturation time, to obtain polymer foam.
    Type: Application
    Filed: July 27, 2016
    Publication date: February 2, 2017
    Inventors: Ly James LEE, Dachao LI, Ying-Chieh YEN, Dajiong FU, Yuen-Yuen D. CHIU, Chiang-Hsiang LIN
  • Publication number: 20150151973
    Abstract: A facile method to produce covalently bonded graphene coating on various solid substrates is disclosed in the present invention. According to one embodiment, a combination of graphite, graphene oxide or graphene and silicon compound with or without a metal containing compound in an air free environment is processed at high temperatures to produce covalent carbide bonding among graphene layers and between graphene and substrate surface.
    Type: Application
    Filed: June 25, 2013
    Publication date: June 4, 2015
    Applicant: The Ohio State University
    Inventors: Ly James Lee, Wenyi Huang, Jianfeng Yu
  • Publication number: 20140256047
    Abstract: A simple and low cost method of producing sealed arrays of laterally ordered nanochannels interconnected to microchannels of tunable size, over large surface areas, is disclosed. The method incorporates DNA combing and subsequent imprinting. Associated micro and macroscale inlets and outlets can be formed in the same process or manufactured later in low cost, non-cleanroom techniques. The techniques embrace two procedures, generating DNA nanostrands and translating these strands into nanoscale constructs via imprinting. Devices incorporating the novel arrays have a first microchannel, a second microchannel and a nanochannel that is substantially linear and which defines an axis. The nanochannel is connected at its open ends to the microchannels, which are aligned along the axis. Methods for precise dose delivery of agents into cells employing the devices in nanoelectroporation methods are also disclosed.
    Type: Application
    Filed: May 20, 2014
    Publication date: September 11, 2014
    Inventors: Ly James Lee, Pouyan E. Boukany, Jingjiao Guan, Nan-Rong Chiou
  • Publication number: 20140094383
    Abstract: Disclosed are compositions and methods for the use of lipoplex nanoparticle chips and arrays in the detection of/diagnosis of a disease or condition.
    Type: Application
    Filed: October 2, 2013
    Publication date: April 3, 2014
    Inventors: Ly James Lee, Kwang Joo Kwak, Bo Yu, Yun Wu, Andrew Lee
  • Patent number: 8507568
    Abstract: Synthesis of polystyrene and/or other thermoplastic polymers or polymer blends which, for example, contain activated carbon and/or bamboo carbon carrying a co-blowing agent such as water and/or at least one of 1-dimensional, 2-dimensional, and 3-dimensional nano/micro-materials in suspension polymerization without using the inverse emulsion process. CO2 or other blowing agent based foaming processes such as extrusion, batch foaming, and injection molding may then be carried out to produce polymer foams that have low density, high-R value, bimodal structures, good mechanical properties, and high fire retardance.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: August 13, 2013
    Assignees: The Ohio State University, Nanomaterial Innovation Ltd
    Inventors: Ly James Lee, Jintao Yang, Nan-Rong Chiou, Shu-Kai Yeh
  • Patent number: 8293140
    Abstract: Novel, simple methods are presented directed to the synthesis of aligned nanofibers of polyaniline and substituted derivatives on a substrate. The production of these fibers is achieved via various methods by controlling the concentration of aniline monomer or substituted aniline derivatives or an oxidant in the reaction medium and maintaining said concentration at a level much lower than conventional polyaniline synthesis methods. Methods are disclosed relating to the use of a permeable membrane to control the release of a monomer and/or oxidant as well as a bulk polymerization method.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: October 23, 2012
    Assignee: The Ohio State University Research Foundation
    Inventors: Arthur J. Epstein, Nan-Rong Chiou, Ly James Lee, Chunmeng Lu
  • Publication number: 20120035353
    Abstract: Novel, simple methods are presented directed to the synthesis of aligned nanofibers of polyaniline and substituted derivatives on a substrate. The production of these fibers is achieved via various methods by controlling the concentration of aniline monomer or substituted aniline derivatives or an oxidant in the reaction medium and maintaining said concentration at a level much lower than conventional polyaniline synthesis methods. Methods are disclosed relating to the use of a permeable membrane to control the release of a monomer and/or oxidant as well as a bulk polymerization method.
    Type: Application
    Filed: October 17, 2011
    Publication date: February 9, 2012
    Inventors: Arthur J. Epstein, Nan-Rong Chiou, Ly James Lee, Chunmeng Lu
  • Patent number: 8038907
    Abstract: Novel, simple methods are presented directed to the synthesis of aligned nanofibers of polyaniline and substituted derivatives on a substrate. The production of these fibers is achieved via various methods by controlling the concentration of aniline monomer or substituted aniline derivatives or an oxidant in the reaction medium and maintaining said concentration at a level much lower than conventional polyaniline synthesis methods. Methods are disclosed relating to the use of a permeable membrane to control the release of a monomer and/or oxidant as well as a bulk polymerization method.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: October 18, 2011
    Assignee: The Ohio State University Research Foundation
    Inventors: Arthur J. Epstein, Nan-Rong Chiou, Ly James Lee, Chunmeng Lu
  • Publication number: 20110240904
    Abstract: Exemplary embodiments of the present invention relate to polystyrene and/or thermoplastic polymer or polymer blend composite foam or a foamable polymeric material precursor, which contains activated carbon and/or at least one of 1-dimensional, 2-dimensional, and 3-dimensional nano/micro-materials in polystyrene and/or thermoplastic polymer and/or polymer blend matrix to carry a co-blowing agent such as water without using any surfactant-like molecules and/or polymers, having or adapted to have the properties of low density, high-R value, good mechanical properties, and fire retardance thereof. Exemplary embodiments of the present invention include various manufacturing methods that may be employed including, but not limited to, extrusion, batch molding, and injection molding. One example includes synthesis and CO2 and water-based extruded foaming of such a material.
    Type: Application
    Filed: May 28, 2009
    Publication date: October 6, 2011
    Applicants: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION, NANOMATERIAL INNOVATION LTD
    Inventors: Nan-Rong Chiou, Ly James Lee, Jintao Yang, Shu-Kai Yeh
  • Publication number: 20110229706
    Abstract: Novel, simple methods are presented directed to the synthesis of aligned nanofibers of polyaniline and substituted derivatives on a substrate. The production of these fibers is achieved via various methods by controlling the concentration of aniline monomer or substituted aniline derivatives or an oxidant in the reaction medium and maintaining said concentration at a level much lower than conventional polyaniline synthesis methods. Methods are disclosed relating to the use of a permeable membrane to control the release of a monomer and/or oxidant as well as a bulk polymerization method.
    Type: Application
    Filed: April 2, 2007
    Publication date: September 22, 2011
    Inventors: Arthur J. Epstein, Nan-Rong Chiou, Ly James Lee, Chunmeng Lu
  • Publication number: 20100099782
    Abstract: Synthesis of polystyrene and/or other thermoplastic polymers or polymer blends which, for example, contain activated carbon and/or bamboo carbon carrying a co-blowing agent such as water and/or at least one of 1-dimensional, 2-dimensional, and 3-dimensional nano/micro-materials in suspension polymerization without using the inverse emulsion process. CO2 or other blowing agent based foaming processes such as extrusion, batch foaming, and injection molding may then be carried out to produce polymer foams that have low density, high-R value, bimodal structures, good mechanical properties, and high fire retardance.
    Type: Application
    Filed: August 11, 2009
    Publication date: April 22, 2010
    Applicants: The Ohio State University Research Foundation, Nanomaterial Innovation LTD
    Inventors: Ly James Lee, Jintao Yang, Nan-Rong Chiou, Shu-Kai Yeh