Patents by Inventor Lyle Arnold

Lyle Arnold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6423535
    Abstract: Methods are provide for quantitatively determining the amount of polynucleotides in a sample. In one method, the distinct polynucleotide targets and standard polynucleotide targets are contacted with detectable probes and independently detectable single or double stranded complements to the standard targets under hybridization conditions. The hybridization pattern from the probe is compared to the hybridization pattern from the standard sequences to obtain quantitative information about the genetic profile of the labeled nucleic acid sample. Also provided are kits for the use of the methods.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: July 23, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Lyle Arnold, Tod Bedilion, Erik Bjeldanes, Thomas P. Theriault, Warren Lei
  • Patent number: 6420114
    Abstract: A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids, undergoing a reaction. The apparatus comprises a means for creating a bubble within the film of fluid, and moving the bubble in the fluid, thereby mixing the fluid.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: July 16, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Tod Bedilion, Lozen Titsworth, Erik Bjeldanes, Douglas Gilliland, Lyle Arnold
  • Patent number: 6410231
    Abstract: The invention provides methods, compositions and systems for detecting multiple single nucleotide polymorphisms (SNPs) in a population of target polynucleotides in parallel in a sandwich assay employing SNP probes, capture polynucleotides and, optionally, auxiliary polynucleotides. The relative affinities of the SNP probes for the corresponding SNP regions can be increased with reagents which normalize the melting temperatures of the probes and/or by positionally facilitating interactions between the SNP probe, the SNP region, the capture polynucleotide and/or the auxiliary polynucleotides, such as through a minor groove binder. The probes may comprise a degenerate set of all possible same-sized polynucleotides and the capture polynucleotides are generally immobilized and arrayed at corresponding discrete elements in high density.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: June 25, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Lyle Arnold, Thomas Theriault, Tod Bedilion
  • Patent number: 6379932
    Abstract: The invention provides methods and compositions for amplifying RNA sequences by (a) hybridizing to a target RNA a first primer comprising a 3′ target RNA hybridizing sequence and a first 5′ defined amplifyable sequence; (b) extending the first primer with a reverse transcriptase to form a first cDNA strand; (c) hybridizing to the first cDNA strand a second primer comprising a 3′ random cDNA hybridizing sequence and a second 5′ defined amplifyable sequence; (d) extending the second primer with a DNA polymerase to form a second cDNA strand; and (e) amplifying the second cDNA strand with a third primer comprising the first 5′ defined amplifyable sequence.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: April 30, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Lyle Arnold, Erik Bjeldanes, Steve Daniel