Abstract: A method for creating a greater pattern (12) comprising creating a first repeating line pattern (14a) comprising printing a first line (16a) onto a substrate, the first line having a weight of from about 0.2 point to about 0.6 point, printing a second line (16b) onto the substrate at least about 0.3 point and less than about 0.8 point from the first line (16a), the second line (16b) having a weight of from about 0.2 point to about 0.6 point, and printing a third line (16c) onto the substrate at least about 0.3 point and less than about 0.8 point from the second line (16b), the third line (16c) having a weight of from about 0.2 point to about 0.6 point, wherein the first, second and third lines (16a, 16b, 16c) are all printed at a first angle.

Abstract: A method for creating a greater pattern (12) comprising creating a first repeating line pattern (14a) comprising printing a first line (16a) onto a substrate, the first line having a weight of from about 0.2 point to about 0.6 point, printing a second line (16b) onto the substrate at least about 0.3 point and less than about 0.8 point from the first line (16a), the second line (16b) having a weight of from about 0.2 point to about 0.6 point, and printing a third line (16c) onto the substrate at least about 0.3 point and less than about 0.8 point from the second line (16b), the third line (16c) having a weight of from about 0.2 point to about 0.6 point, wherein the first, second and third lines (16a, 16b, 16c) are all printed at a first angle.

Abstract: The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).

Abstract: The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).

Abstract: Provided are methods of purifying and crystallizing Streptococcus pneumoniae acyl carrier protein synthase (AcpS) enzyme, crystals of AcpS, the use of such crystals to determine the three-dimensional structure of AcpS enzymes, and the three-dimensional structure of AcpS. The three-dimensional crystal structure of AcpS can be used in medical diagnostics to produce antibodies that permit detection of Streptococcus pneumoniae both in vitro and in vivo. The three-dimensional crystal structure of AcpS can also be used in pharmaceutical discovery and development to identify and design compounds that inhibit the biochemical activity of AcpS enzyme in bacteria. Inhibitory compounds identified in this way can be optimized by structure/activity studies to develop antibacterial pharmaceutical compounds useful for the prevention or treatment of bacterial infections.