Patents by Inventor Lyle D. Crossland
Lyle D. Crossland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7202085Abstract: DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.Type: GrantFiled: June 3, 2005Date of Patent: April 10, 2007Assignee: Calgene LLCInventors: Tim N. Oulmassov, Kevin E. McBride, Paula C. Miller, John C. Anderson, Lyle D. Crossland, Thomas H. Adams, Barbara A. Qurollo, Victoria Gavrias
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Patent number: 6943243Abstract: DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.Type: GrantFiled: February 6, 2003Date of Patent: September 13, 2005Assignee: Calgene LLCInventors: Tim N. Oulmassov, Kevin E. McBride, Paula C. Miller, John C. Anderson, Lyle D. Crossland, Thomas H. Adams, Barbara A. Qurollo, Victoria Gavrias
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Patent number: 6939711Abstract: The present invention is drawn to a method of controlling gene expression in plants. Specifically, the method comprises obtaining a transgenic plant comprising at least two receptor expression cassettes and at least one target expression cassette. The first receptor expression cassette comprises a nucleotide sequence for a 5? regulatory region operably linked to a nucleotide sequence which encodes a first receptor polypeptide, and a 3? termination region. The second receptor expression cassette comprises a nucleotide sequence for a 5? regulatory region operably linked to a nucleotide sequence which encodes a second receptor polypeptide, and a 3? termination region.Type: GrantFiled: March 21, 2001Date of Patent: September 6, 2005Assignee: Syngenta Investment CorporationInventors: Stephen A. Goff, Lyle D. Crossland, Laura S. Privalle
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Method of producing transgenic maize using direct transformation of commercially important genotypes
Publication number: 20030237117Abstract: Methods for transformation of maize with nucleic acid sequences of interest are disclosed. The method involves subjecting immature zygotic embryos or Type I callus to high velocity microprojectile bombardment. The method is capable of producing transformed maize lines of commercial importance and their hybrid combinations.Type: ApplicationFiled: April 30, 2002Publication date: December 25, 2003Inventors: Michael Koziel, Nalini Desai, Kelly Lewis, Vance Kramer, Gregory Warren, Steve Evola, Lyle D. Crossland, Martha Wright, Ellis Merlin, Karen Launis, Steven J. Rothstein, Cindy Bowman, John L. Dawson, Erik Dunder, Gary M. Pace, Jan Suttie, Nadine Carozzi, Annick De Framond, James O. Linder, Robert L. Miller, Bruce W. Skillings, Alan W. Mousel, Albert R. Hornbrook, Christopher P. Clucas, Moez R. Meghji, Andreas H. Tanner, Francis E. Cassagne, Gilles Pollini, Terry Ray Colbert, Francis P. Cammack -
Publication number: 20030224483Abstract: DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.Type: ApplicationFiled: February 6, 2003Publication date: December 4, 2003Inventors: Tim N. Oulmassov, Kevin E. McBride, Paula C. Miller, John C. Anderson, Lyle D. Crossland, Thomas H. Adams, Barbara A. Qurollo, Victoria Gavrias
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Patent number: 6518066Abstract: DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (“lux box”) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.Type: GrantFiled: June 30, 2000Date of Patent: February 11, 2003Assignee: Calgene LLCInventors: Tim N. Oulmassov, Kevin E. McBride, Paula C. Miller, John C. Anderson, Lyle D. Crossland, Thomas H. Adams, Barbara A. Qurollo, Victoria Gavrias
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Method of producing transgenic maize using direct transformation of commercially important genotypes
Patent number: 6403865Abstract: Methods for transformation of maize with nucleic acid sequences of interest are disclosed. The method involves subjecting immature zygotic embryos or Type I callus to high velocity microprojectile bombardment. The method is capable of producing transformed maize lines of commercial importance and their hybrid combinations.Type: GrantFiled: May 10, 1995Date of Patent: June 11, 2002Assignee: Syngenta Investment Corp.Inventors: Michael G. Koziel, Nalini M. Desai, Kelly S. Lewis, Vance C. Kramer, Gregory W. Warren, Stephen V. Evola, Lyle D. Crossland, Martha S. Wright, Ellis J. Merlin, Karen L. Launis, Steven J. Rothstein, Cindy G. Bowman, John L. Dawson, Erik M. Dunder, Gary M. Pace, Janet L. Suttie, Nadine Carozzi, Annick De Framond, James O. Linder, Robert L. Miller, Bruce W. Skillings, Alan W. Mousel, Albert R. Hornbrook, Christopher P. Clucas, Moez Rajabali Meghji, Andreas H. Tanner, Francis E. Cassagne, Gilles Pollini, Terry Ray Colbert, Francis P. Cammack -
Publication number: 20010022004Abstract: The present invention is drawn to a method of controlling gene expression in plants. Specifically, the method comprises obtaining a transgenic plant comprising at least two receptor expression cassettes and at least one target expression cassette. The first receptor expression cassette comprises a nucleotide sequence for a 5′ regulatory region operably linked to a nucleotide sequence which encodes a first receptor polypeptide, and a 3′ termination region. The second receptor expression cassette comprises a nucleotide sequence for a 5′ regulatory region operably linked to a nucleotide sequence which encodes a second receptor polypeptide, and a 3′ termination region.Type: ApplicationFiled: March 21, 2001Publication date: September 13, 2001Inventors: Stephen A. Goff, Lyle D. Crossland, Laura S. Privalle
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Patent number: 6147282Abstract: The present invention is drawn to a method of controlling gene expression in plants. Specifically, the method comprises obtaining a transgenic plant comprising at least two receptor expression cassettes and at least one target expression cassette. The first receptor expression cassette comprises a nucleotide sequence for a 5' regulatory region operably linked to a nucleotide sequence which encodes a first receptor polypeptide, and a 3' termination region. The second receptor expression cassette comprises a nucleotide sequence for a 5' regulatory region operably linked to a nucleotide sequence which encodes a second receptor polypeptide, and a 3' termination region.Type: GrantFiled: January 20, 1999Date of Patent: November 14, 2000Assignee: Novartis Finance CorporationInventors: Stephen A. Goff, Lyle D. Crossland, Laura S. Privalle
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Patent number: 5880333Abstract: The present invention is drawn to a method of controlling gene expression in plants. Specifically, the method comprises obtaining a transgenic plant comprising at least two receptor expression cassettes and at least one target expression cassette. The first receptor expression cassette comprises a nucleotide sequence for a 5' regulatory region operably linked to a nucleotide sequence which encodes a first receptor polypeptide, and a 3' termination region. The second receptor expression cassette comprises a nucleotide sequence for a 5' regulatory region operably linked to a nucleotide sequence which encodes a second receptor polypeptide, and a 3' termination region.Type: GrantFiled: January 21, 1998Date of Patent: March 9, 1999Assignee: Novartis Finance CorporationInventors: Stephen A. Goff, Lyle D. Crossland, Laura S. Privalle
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Patent number: 5859336Abstract: DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.Type: GrantFiled: June 2, 1995Date of Patent: January 12, 1999Assignee: Novartis CorporationInventors: Michael G. Koziel, Nalini M. Desai, Kelly S. Lewis, Gregory W. Warren, Stephen V. Evola, Lyle D. Crossland, Martha S. Wright, Ellis J. Merlin, Karen L. Launis, Cindy G. Bowman, John L. Dawson, Erik M. Dunder, Gary M. Pace, Janet L. Suttie
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Patent number: 5824542Abstract: The present invention provides a dual method for producing male-sterile plants. Two genetically transformed plants, parents 1 and 2 are crossed to obtain male-sterile offspring. Parent 1 is transformed with an expression cassette comprising a nucleotide sequence encoding an anther-specific promoter which is operably linked to a nucleotide sequence encoding a transactivator. Parent 2 is transformed with an expression cassette comprising a target nucleotide sequence, which is capable of being activated by the transactivator, operably linked to a nucleotide sequence which encodes RNA or a polypeptide which will disrupt the formation of viable pollen. Therefore, crossing parent 1 with parent 2 results in male-sterile offspring. The male-sterile plants are useful for producing hybrid seed.The invention also provides compositions and methods for high level expression of a coding region of interest in a plant.Type: GrantFiled: May 23, 1995Date of Patent: October 20, 1998Assignee: Novartis Finance CorporationInventors: Lyle D. Crossland, Annmarie Tuttle, Jeffrey I. Stein
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Patent number: 5659124Abstract: The present invention provides a dual method for producing male-sterile plants. Two genetically transformed plants, parents 1 and 2 are crossed to obtain male-sterile offspring. Parent 1 is transformed with an expression cassette comprising a nucleotide sequence encoding an anther-specific promoter which is operably linked to a nucleotide sequence encoding a transactivator. Parent 2 is transformed with an expression cassette comprising a target nucleotide sequence, which is capable of being activated by the transactivator, operably linked to a nucleotide sequence which encodes RNA or a polypeptide which will disrupt the formation of viable pollen. Therefore, crossing parent 1 with parent 2 results in male-sterile offspring. The male-sterile plants are useful for producing hybrid seed.The invention also provides compositions and methods for high level expression of a coding region of interest in a plant.Type: GrantFiled: January 3, 1995Date of Patent: August 19, 1997Assignee: Novartis CorporationInventors: Lyle D. Crossland, Annmarie Tuttle, Jeffrey I. Stein
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Patent number: 5625136Abstract: DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.Type: GrantFiled: September 25, 1992Date of Patent: April 29, 1997Assignee: Ciba-Geigy CorporationInventors: Michael G. Koziel, Nalini M. Desai, Kelly S. Lewis, Vance C. Kramer, Gregory W. Warren, Stephen V. Evola, Lyle D. Crossland, Martha S. Wright, Ellis J. Merlin, Karen L. Launis, Steven J. Rothstein, Cindy G. Bowman, John L. Dawson, Erik M. Dunder, Gary M. Pace, Janet L. Suttie
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Patent number: 5477002Abstract: cDNA sequences are disclosed which are expressed specifically in the anther of a plant. Genomic DNA sequences corresponding to the cDNA clones are obtained using the cDNA clones as hybridization probes. Recombinant, or chimeric, DNA sequences are constructed in which the promoter sequence from anther-specific genomic clones are operatively linked to a DNA sequence coding for a desired polypeptide. Transgenic plants are made in which the chimeric DNA sequences are expressed in the anther of the transgenic plant. In a preferred embodiment, the coding DNA sequence expresses a polypeptide which will disrupt formation of viable pollen, resulting in a male-sterile plant.Type: GrantFiled: March 7, 1994Date of Patent: December 19, 1995Assignee: Ciba-Geigy CorporationInventors: Annmarie B. Tuttle, Lyle D. Crossland
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Patent number: 5409823Abstract: The present invention provides a dual method for producing male-sterile plants. Two genetically transformed plants, parents 1 and 2 are crossed to obtain male-sterile offspring. Parent 1 is transformed with an expression cassette comprising a nucleotide sequence encoding an anther-specific promoter which is operably linked to a nucleotide sequence encoding a transactivator. Parent 2 is transformed with an expression cassette comprising a target nucleotide sequence, which is capable of being activated by the transactivator, operably linked to a nucleotide sequence which encodes RNA or a polypeptide which will disrupt the formation of viable pollen. Therefore, crossing parent 1 with parent 2 results in male-sterile offspring. The male-sterile plants are useful for producing hybrid seed.The invention also provides compositions and methods for high level expression of a coding region of interest in a plant.Type: GrantFiled: September 24, 1992Date of Patent: April 25, 1995Assignee: Ciba-Geigy CorporationInventors: Lyle D. Crossland, Annmarie Tuttle, Jeffrey I. Stein