Patents by Inventor Lyle D. Small

Lyle D. Small has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250032648
    Abstract: The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent. whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.
    Type: Application
    Filed: October 8, 2024
    Publication date: January 30, 2025
    Applicant: Lahjavida, LLC
    Inventors: Lyle D. Small, Ruizheng Wang, Shane M. Crippen
  • Patent number: 12109276
    Abstract: The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent, whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: October 8, 2024
    Assignee: Lahjavida, LLC
    Inventors: Lyle D. Small, Ruizheng Wang, Shane M. Crippen
  • Publication number: 20200289676
    Abstract: The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent, whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.
    Type: Application
    Filed: March 11, 2020
    Publication date: September 17, 2020
    Applicant: Lahjavida, LLC
    Inventors: Lyle D. Small, Ruizheng Wang, Shane M. Crippen
  • Patent number: 10605681
    Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: March 31, 2020
    Assignee: Chromatic Technologies, Inc.
    Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
  • Patent number: 10585080
    Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: March 10, 2020
    Assignee: Chromatic Technologies, Inc.
    Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
  • Publication number: 20190331650
    Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.
    Type: Application
    Filed: July 8, 2019
    Publication date: October 31, 2019
    Applicant: Chromatic Technologies, Inc.
    Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
  • Patent number: 10345278
    Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: July 9, 2019
    Assignee: Chromatic Technologies, Inc.
    Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
  • Publication number: 20190011318
    Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.
    Type: Application
    Filed: September 12, 2018
    Publication date: January 10, 2019
    Applicant: Chromatic Technologies, Inc.
    Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
  • Publication number: 20180120275
    Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.
    Type: Application
    Filed: September 21, 2017
    Publication date: May 3, 2018
    Applicant: Chromatic Technologies, Inc.
    Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
  • Patent number: 6139779
    Abstract: A method of making a solvent based ink formulation which includes a thermochromic pigment, wherein the pigment being formed of microcapsules, includes drying a slurry that contains the pigment to a solids concentration between 70% and 99%, mixing the dried slurry in an appropriate mixing base, and adding any desired ink components to the base formulation. Each microcapsule contains a reversible thermochromic coloring material which exhibits a visible change in color between a first color state and a second color state in response to a change in temperature. Acceptable ink components include a gel vehicle, a free flow vehicle, a drying agent, a lithographic varnish, an ink wax, a polyester vehicle, a polyglycol solvent, a colloidal dispersion resin water, and a defoamer.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: October 31, 2000
    Assignee: Chromatic Technologies, Inc.
    Inventors: Lyle D. Small, Gerald Highberger
  • Patent number: 5997849
    Abstract: A method of making a solvent based ink formulation which includes a thermochromic pigment, wherein the pigment being formed of microcapsules, includes drying a slurry that contains the pigment to a solids concentration between 80% and 95%, mixing the dried slurry in an appropriate mixing base, and adding any desired ink components to the base formulation. Each microcapsule contains a reversible thermochromic coloring material which exhibits a visible change in color between a first color state and a second color state in response to a change in temperature. Acceptable ink components include a gel vehicle, a free flow vehicle, a drying agent, a lithographic varnish, an ink wax, a polyester vehicle, a polyglycol solvent, a colloidal dispersion resin, water, and a defoamer.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: December 7, 1999
    Assignee: Chromatic Technologies, Inc.
    Inventors: Lyle D. Small, Gerald Highberger
  • Patent number: 5591255
    Abstract: The present invention comprises a series of discoveries related to the problems associated with formulations that destroy the color change properties of thermochromic encapsulated dyes. One aspect of the present invention is the discovery of a method of correcting these formulations to allow the addition of thermochromic dyes. Certain solvents destroy the dye, therefore any aldehydes, ketones, and diols, and most aromatic compounds should be removed from the formulation and if needed they should be replaced with solvents preferably having a large molecular weight (i.e. greater than 100 and low reactivity). Secondly, the formulation should be adjusted to be neutral (i.e. 6.5-7.5 pH) or have a low acid value. These two adjustments will allow the thermochromic dyes to added to the formulation without a loss of its color change properties.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: January 7, 1997
    Assignee: Chromatic Technologies, Inc.
    Inventors: Lyle D. Small, Gerald Highberger