Patents by Inventor Lyle D. Small
Lyle D. Small has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250032648Abstract: The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent. whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.Type: ApplicationFiled: October 8, 2024Publication date: January 30, 2025Applicant: Lahjavida, LLCInventors: Lyle D. Small, Ruizheng Wang, Shane M. Crippen
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Patent number: 12109276Abstract: The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent, whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.Type: GrantFiled: March 11, 2020Date of Patent: October 8, 2024Assignee: Lahjavida, LLCInventors: Lyle D. Small, Ruizheng Wang, Shane M. Crippen
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Publication number: 20200289676Abstract: The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent, whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.Type: ApplicationFiled: March 11, 2020Publication date: September 17, 2020Applicant: Lahjavida, LLCInventors: Lyle D. Small, Ruizheng Wang, Shane M. Crippen
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Patent number: 10605681Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.Type: GrantFiled: September 12, 2018Date of Patent: March 31, 2020Assignee: Chromatic Technologies, Inc.Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
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Patent number: 10585080Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.Type: GrantFiled: July 8, 2019Date of Patent: March 10, 2020Assignee: Chromatic Technologies, Inc.Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
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Publication number: 20190331650Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.Type: ApplicationFiled: July 8, 2019Publication date: October 31, 2019Applicant: Chromatic Technologies, Inc.Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
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Patent number: 10345278Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.Type: GrantFiled: September 21, 2017Date of Patent: July 9, 2019Assignee: Chromatic Technologies, Inc.Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
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Publication number: 20190011318Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.Type: ApplicationFiled: September 12, 2018Publication date: January 10, 2019Applicant: Chromatic Technologies, Inc.Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
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Publication number: 20180120275Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.Type: ApplicationFiled: September 21, 2017Publication date: May 3, 2018Applicant: Chromatic Technologies, Inc.Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
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Patent number: 6139779Abstract: A method of making a solvent based ink formulation which includes a thermochromic pigment, wherein the pigment being formed of microcapsules, includes drying a slurry that contains the pigment to a solids concentration between 70% and 99%, mixing the dried slurry in an appropriate mixing base, and adding any desired ink components to the base formulation. Each microcapsule contains a reversible thermochromic coloring material which exhibits a visible change in color between a first color state and a second color state in response to a change in temperature. Acceptable ink components include a gel vehicle, a free flow vehicle, a drying agent, a lithographic varnish, an ink wax, a polyester vehicle, a polyglycol solvent, a colloidal dispersion resin water, and a defoamer.Type: GrantFiled: July 27, 1999Date of Patent: October 31, 2000Assignee: Chromatic Technologies, Inc.Inventors: Lyle D. Small, Gerald Highberger
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Patent number: 5997849Abstract: A method of making a solvent based ink formulation which includes a thermochromic pigment, wherein the pigment being formed of microcapsules, includes drying a slurry that contains the pigment to a solids concentration between 80% and 95%, mixing the dried slurry in an appropriate mixing base, and adding any desired ink components to the base formulation. Each microcapsule contains a reversible thermochromic coloring material which exhibits a visible change in color between a first color state and a second color state in response to a change in temperature. Acceptable ink components include a gel vehicle, a free flow vehicle, a drying agent, a lithographic varnish, an ink wax, a polyester vehicle, a polyglycol solvent, a colloidal dispersion resin, water, and a defoamer.Type: GrantFiled: March 24, 1997Date of Patent: December 7, 1999Assignee: Chromatic Technologies, Inc.Inventors: Lyle D. Small, Gerald Highberger
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Patent number: 5591255Abstract: The present invention comprises a series of discoveries related to the problems associated with formulations that destroy the color change properties of thermochromic encapsulated dyes. One aspect of the present invention is the discovery of a method of correcting these formulations to allow the addition of thermochromic dyes. Certain solvents destroy the dye, therefore any aldehydes, ketones, and diols, and most aromatic compounds should be removed from the formulation and if needed they should be replaced with solvents preferably having a large molecular weight (i.e. greater than 100 and low reactivity). Secondly, the formulation should be adjusted to be neutral (i.e. 6.5-7.5 pH) or have a low acid value. These two adjustments will allow the thermochromic dyes to added to the formulation without a loss of its color change properties.Type: GrantFiled: September 30, 1994Date of Patent: January 7, 1997Assignee: Chromatic Technologies, Inc.Inventors: Lyle D. Small, Gerald Highberger