Patents by Inventor Lyle David Isaacs

Lyle David Isaacs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MOLECULAR CONTAINERS AND METHODS OF MAKING AND USING SAME
    Publication number: 20240124476
    Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
    Type: Application
    Filed: December 26, 2023
    Publication date: April 18, 2024
    Inventors: Lyle David Isaacs, Volker Briken, Gaya Hettiarachchi, Da Ma, Duc M. Nguyen
  • Molecular containers and methods of making and using same
    Patent number: 11897893
    Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: February 13, 2024
    Assignee: University of Maryland, College Park
    Inventors: Lyle David Isaacs, Volker Briken, Gaya Hettiarachchi, Da Ma, Duc M. Nguyen
  • ACYCLIC CUCURBITURILS, METHODS OF MAKING SAME, AND USES THEREOF
    Publication number: 20230203052
    Abstract: Disclosed herein are acyclic sulfated cucurbit[n]uril containing sulfate substituent(s), compositions containing the same, and method of preparation thereof. These compounds are useful, for example, as sequestering agents for drugs of abuse.
    Type: Application
    Filed: April 20, 2021
    Publication date: June 29, 2023
    Inventors: Lyle David ISAACS, Xiaoyong LU
  • SULFATED PILLARARENES, METHODS OF MAKING SAME, AND USES THEREOF
    Publication number: 20230174468
    Abstract: Provided are sulfated pillararenes and methods of making and using same. The pillararenes have macrocycle core having a plurality of aryl groups, attached (e.g., covalently bonded) in a para orientation to the adjacent methylene groups. The pillararenes have a hydrophobic cavity. The hydrophobic cavity may be used to sequester various materials or to deliver materials sequestered therein.
    Type: Application
    Filed: August 29, 2022
    Publication date: June 8, 2023
    Inventors: Lyle David ISAACS, Weijian XUE
  • CUCURBITURIL MOLECULAR CONTAINERS AND METHODS OF USING SAME
    Publication number: 20210379099
    Abstract: Disclosed herein are water-soluble, cyclic cucurbit[n]uril, compositions containing the same, methods of preparation thereof, and uses thereof. These compounds are useful, for example, as sequestering agents for various agents, such as, for example, drugs of abuse.
    Type: Application
    Filed: June 1, 2021
    Publication date: December 9, 2021
    Inventors: Lyle David ISAACS, Steven MURKLI
  • MOLECULAR CONTAINERS AND METHODS OF MAKING AND USING SAME
    Publication number: 20210206774
    Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
    Type: Application
    Filed: December 14, 2020
    Publication date: July 8, 2021
    Inventors: Lyle David Isaacs, Volker Briken, Gaya Hettiarachchi, Da Ma, Duc M. Nguyen
  • Acyclic cucurbit[n]uril type molecular containers to treat intoxication and decrease relapse rate in substance abuse disorders
    Patent number: 9956229
    Abstract: Provided are methods for reversing the effects of drugs of abuse. The method involves administering acyclic CB[n]-type compounds to a mammal in need of the reversal of the effects from a drug of abuse.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: May 1, 2018
    Assignees: University of Maryland, College Park, General Hospital Corporation
    Inventors: Lyle David Isaacs, Matthias Eikermann, Cristina Cusin, Joseph Cotten
  • ACYCLIC CUCURBIT[N]URIL TYPE MOLECULAR CONTAINERS TO TREAT INTOXICATION AND DECREASE RELAPSE RATE IN SUBSTANCE ABUSE DISORDERS
    Publication number: 20170246180
    Abstract: Provided are methods for reversing the effects of drugs of abuse. The method involves administering acyclic CB[n]-type compounds to a mammal in need of the reversal of the effects from a drug of abuse.
    Type: Application
    Filed: October 19, 2015
    Publication date: August 31, 2017
    Inventors: Lyle David Isaacs, Matthias Eikermann, Cristina Cusin, Joseph Cotten
  • MOLECULAR CONTAINERS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170137431
    Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
    Type: Application
    Filed: January 27, 2017
    Publication date: May 18, 2017
    Inventors: Lyle David Isaacs, Volker Briken, Gaya Hettiarachchi, Da Ma, Duc M. Nguyen
  • Molecular containers and methods of making and using same
    Patent number: 9567344
    Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: February 14, 2017
    Assignee: University of Maryland, College Park
    Inventors: Lyle David Isaacs, Volker Briken, Da Ma, Gaya Hettiarachchi, Duc M. Nguyen
  • Molecular containers and methods of making and using same
    Patent number: 9566351
    Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: February 14, 2017
    Assignee: University of Maryland, College Park
    Inventors: Volker Briken, Lyle David Isaacs, Gaya Hettiarachchi, Ben Zhang
  • Reversal of drug-induced neuromuscular block using novel molecular containers
    Patent number: 9469648
    Abstract: Provided are methods for reversing the effects of agents used for muscular immobilization and/or loss of consciousness and/or loss of pain perception. The method comprises administering a composition comprising acyclic CB[n]-type compounds to an individual in need of reversal of the effects of neuromuscular blocking agents and/or anesthetic agents such that the effects of the agent(s) are partially fully reversed.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: October 18, 2016
    Assignees: University of Maryland, College Park, General Hospital Corporation
    Inventors: Lyle David Isaacs, Da Ma, Matthias Eikermann
  • MOLECULAR CONTAINERS AND METHODS OF MAKING AND USING SAME
    Publication number: 20150328334
    Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
    Type: Application
    Filed: June 9, 2015
    Publication date: November 19, 2015
    Inventors: Volker Briken, Lyle David Isaacs, Gaya Hettiarachchi, Ben Zhang
  • MOLECULAR CONTAINERS AND METHODS OF MAKING AND USING SAME
    Publication number: 20140094529
    Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
    Type: Application
    Filed: October 13, 2011
    Publication date: April 3, 2014
    Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Lyle David Isaacs, Volker Briken, Gaya Hettiarachchi, Da Ma, Duc M. Nguyen
  • REVERSAL OF DRUG-INDUCED NEUROMUSCULAR BLOCK USING NOVEL MOLECULAR CONTAINERS
    Publication number: 20130345273
    Abstract: Provided are methods for reversing the effects of agents used for muscular immobilization and/or loss of consciousness and/or loss of pain perception. The method comprises administering a composition comprising acyclic CB[n]-type compounds to an individual in need of reversal of the effects of neuromuscular blocking agents and/or anesthetic agents such that the effects of the agent(s) are partially fully reversed.
    Type: Application
    Filed: October 13, 2011
    Publication date: December 26, 2013
    Applicants: GENERAL HOSPITAL CORPORATION, UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Lyle David Isaacs, Da Ma, Matthias Eikermann
  • Introverted CB[n] compounds
    Patent number: 8513409
    Abstract: Inverted cucurbituril compounds having at least one pair of hydrogen atoms protruding into an internal molecular cavity thereof.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: August 20, 2013
    Assignees: University of Maryland, Pohang University of Science and Technology
    Inventors: Kimoon Kim, Sang-Kyu Park, Young Ho Ko, Hyunuk Kim, Youngkook Kim, Narayanan Selvapalam, Lyle David Isaacs, Simin Liu
  • Nor-seco-bis-nor-seco, tris-nor-seco, and higher nor-seco-cucurbit[n]uril compounds
    Patent number: 8299269
    Abstract: Nor-seco-type cucurbit[n]uril compounds and methylene bridged glycoluril oligomers are produced by reacting glycoluril and formaldehyde in strong organic or mineral acid at a temperature adequate to condense the reactants. These compounds are characterized by lacking —CH2— groups rendering their internal cavities more open and, for example, more responsive to guest compounds.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: October 30, 2012
    Assignee: University of Maryland
    Inventors: Lyle David Isaacs, Wei-Hao Huang
  • Introverted CB[N] Compounds
    Publication number: 20100010215
    Abstract: Inverted cucurbituril compounds having at least one pair of hydrogen atoms protruding into an internal molecular cavity thereof.
    Type: Application
    Filed: July 24, 2006
    Publication date: January 14, 2010
    Applicant: THE UNIVERSITY OF MARYLAND
    Inventors: Lyle David Isaacs, Simin Liu, Kimoon Kim, Sang-Kyu Park, Young Ho Ko, Hyunuk Kim, Youngkook Kim, Narayanan Selvapalam
  • Nor-Seco-Bis-Nor-Seco, Tris-Nor-Seco, and Higher Nor-Seco-Cucurbit[n]Uril Compounds
    Publication number: 20090072191
    Abstract: Nor-seco-type cucurbit[n]uril compounds and methylene bridged glycoluril oligomers are produced by reacting glycoluril and formaldehyde in strong organic or mineral acid at a temperature adequate to condense the reactants. These compounds are characterized by lacking —CH2— groups rendering their internal cavities more open and, for example, more responsive to guest compounds.
    Type: Application
    Filed: October 20, 2006
    Publication date: March 19, 2009
    Inventors: Lyle David Isaacs, Wei-Hao Huang