Patents by Inventor Lyle Spruce

Lyle Spruce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseases
    Publication number: 20060160796
    Abstract: The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia:
    Type: Application
    Filed: March 20, 2006
    Publication date: July 20, 2006
    Inventors: Magnus Pfahl, Catherine Tachdjian, Lyle Spruce, Hussien Al-Shamma, Mohamed Boudjelal, Andrea Fanjul, Torsten Wiemann, David Pleynet
  • Substituted heterocycles for the treatment of diabetes and other diseases
    Publication number: 20060004059
    Abstract: The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.
    Type: Application
    Filed: August 24, 2005
    Publication date: January 5, 2006
    Inventors: Magnus Pfahl, Catherine Tachdjian, Hussein Al-Shamma, Andrea Fanjul, David Pleynet, Lyle Spruce
  • RXR activating molecules
    Publication number: 20050209286
    Abstract: Disclosed are molecules that activate an RXR receptor, wherein the molecule comprises an RXR binding portion which binds the RXR receptor and comprises a side pocket contacting residue which contacts a side-pocket 1 of an RXR receptor.
    Type: Application
    Filed: March 1, 2005
    Publication date: September 22, 2005
    Inventors: Magnus Pfahl, Catherine Tachdjian, Hussien Al-Shamma, Andrea Fanjul, David Pleynet, Lyle Spruce, Richard Fine, James Zapf, Jianhua Guo, Karine Jakubowicz-Jaillardon
  • Imidazolidinedione derivatives for the treatment of diabetes and other diseases
    Publication number: 20050070581
    Abstract: The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.
    Type: Application
    Filed: July 19, 2004
    Publication date: March 31, 2005
    Inventors: Magnus Pfahl, Catherine Tachdjian, Hussien Al-Shamma, Andrea Fanjul, David Pleynet, Lyle Spruce
  • Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
    Publication number: 20050014767
    Abstract: The invention relates to certain compounds whose structures are shown below, and their pharmaceutically acceptable salts and prodrugs, and pharmaceutical compositions thereof, which are useful for treating treating diseases of uncontrolled cellular proliferation, including cancer.
    Type: Application
    Filed: January 29, 2004
    Publication date: January 20, 2005
    Inventors: Magnus Pfahl, Catherine Tachdjian, Torsten Wiemann, Christopher Cow, Lyle Spruce, Andrea Giachino, Allan Kaspar, James Zapf
  • Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
    Publication number: 20030176642
    Abstract: The present invention relates to certain substituted oxadiazole peptoids and nonpeptoids useful as inhibitors of serine proteases, especially human neutophil elastase (HNE). Compounds of the present invention are useful for the treatment or amelioration of symptoms of adult respiratory distress syndrome, septic shock, and multiple organ failure. Processes mediated by HNE are also implicated in conditions such as arthritis, periodontal disease, glomerulonephritis, and cystic fibrosis.
    Type: Application
    Filed: January 30, 2003
    Publication date: September 18, 2003
    Inventors: Albert Gyorkos, Lyle Spruce, Kazuyuki Ohmoto, Kazuhito Kawabata
  • Peptoid and nonpeptoid containing &agr;-keto oxadiazoles as serine protease inhibitors
    Patent number: 6548638
    Abstract: The present invention relates to certain substituted oxadiazole peptoids and nonpeptoids useful as inhibitors of serine proteases, especially human neutophil elastase (HNE). Compounds of the present invention are useful for the treatment or amelioration of symptoms of adult respiratory distress syndrome, septic shock, and multiple organ failure. Processes mediated by HNE are also implicated in conditions such as arthritis, periodontal disease, glomerulonephritis, and cystic fibrosis.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: April 15, 2003
    Assignee: Cortech, Inc.
    Inventors: Albert Gyorkos, Lyle Spruce, Kazuyuki Ohmoto, Kazuhito Kawabata
  • Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
    Publication number: 20020010315
    Abstract: The present invention relates to certain substituted oxadiazole peptoids and nonpeptoids useful as inhibitors of serine proteases, especially human neutophil elastase (HNE). Compounds of the present invention are useful for the treatment or amelioration of symptoms of adult respiratory distress syndrome, septic shock, and multiple organ failure. Processes mediated by HNE are also implicated in conditions such as arthritis, periodontal disease, glomerulonephritis, and cystic fibrosis.
    Type: Application
    Filed: April 26, 2001
    Publication date: January 24, 2002
    Inventors: Albert Gyorkos, Lyle Spruce, Kazuyuki Ohmoto, Kazuhito Kawabata
  • Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
    Patent number: 6255453
    Abstract: The present invention relates to certain substituted oxadiazole peptoids and nonpeptoids useful as inhibitors of serine proteases, especially human neutophil elastase (HNE). Compounds of the present invention are useful for the treatment or amelioration of symptoms of adult respiratory distress syndrome, septic shock, and multiple organ failure. Processes mediated by HNE are also implicated in conditions such as arthritis, periodontal disease, glomerulonephritis, and cystic fibrosis.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: July 3, 2001
    Assignee: Cortech, Inc.
    Inventors: Albert Gyorkos, Lyle Spruce, Kazuyuki Ohmoto, Kazuhito Kawabata