Patents by Inventor Lyn H. Jones

Lyn H. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230236170
    Abstract: Disclosed are methods, assays, and kits for identifying a ligand to a biological molecule, such as a protein, a lipid, a carbohydrate, or a nucleic acid. The disclosed methods may be a quantitative binding assay against targets, which sidesteps the challenge of target purification, and may provide a systematic approach to discover and target allosteric binding sites.
    Type: Application
    Filed: October 15, 2020
    Publication date: July 27, 2023
    Inventors: Matthew T. Labenski, Terry J. Rettenmaier, Lyn H. Jones, Giovanni Muncipinto
  • Publication number: 20230192644
    Abstract: Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, and tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 22, 2023
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael S. Gray, Eric S. Fischer, Alyssa Verano, Hu Liu, Tinghu Zhang, Lyn H. Jones, Eric S. Wang, Radoslaw Nowak, Jianwei Che
  • Publication number: 20210371403
    Abstract: Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with a mutation in a protein.
    Type: Application
    Filed: September 20, 2019
    Publication date: December 2, 2021
    Inventors: Giovanni Muncipinto, Lyn H. Jones, Terry J. Rettenmaier, John A. Malona
  • Publication number: 20210300898
    Abstract: Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with a mutation in a protein.
    Type: Application
    Filed: September 20, 2019
    Publication date: September 30, 2021
    Inventors: Giovanni Muncipinto, Lyn H. Jones, Terry J. Rettenmaier
  • Publication number: 20210299070
    Abstract: Disclosed are methods of treating creatine transporter deficiency, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that increases transport of a substrate by a mutant or wild-type creatine transporter. Also disclosed are methods of increasing transport of guanidinoacetic acid or a salt thereof across the blood-brain barrier of a mammal, and methods of decreasing accumulation or the concentration of guanidinoacetic acid or a salt thereof in a mammalian cell.
    Type: Application
    Filed: September 20, 2019
    Publication date: September 30, 2021
    Inventors: Giovanni Muncipinto, Lyn H. Jones, Terry J. Rettenmaier
  • Publication number: 20040116350
    Abstract: The invention relates generally to the field of immunology. More specifically, the invention relates the finding that antibodies can generate superoxide and hydrogen peroxide from singlet oxygen. Accordingly, methods and compositions able to increase or decrease oxidative stress are provided. Also provided are screening assays to identify agents that modulate the ability of a antibody to generate superoxide and hydrogen peroxide. Such agents can be used therapeutically to treat patients in need. Further, the invention provides methods to use antibodies in immunoassays.
    Type: Application
    Filed: December 19, 2003
    Publication date: June 17, 2004
    Inventors: Paul Wentworth Jr, Anita D. Wentworth, Lyn H. Jones, Kim D. Janda, Richard A. Lerner