Patents by Inventor Lyndsey M. Muehling

Lyndsey M. Muehling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for preventing and treating rhinovirus infections
    Patent number: 10363299
    Abstract: An analysis of human CD4+ T-cell epitopes of RV capsid proteins with cross-reactive potential was performed, peptide epitopes of RV-A16 capsid proteins VP1 and VP2 were identified, RV-specific CD4+ T cells were phenotyped for surface markers and cytokine profiles using flow cytometry, and it was found that, among non-infected subjects, circulating RV-A16-specific CD4+ T cells detected at the highest frequencies targeted 10 unique epitopes with diverse HLA-DR binding capacity. T-cell epitopes localized to conserved regions of significance to the virus and were enriched for HLA class I and II binding motifs and were activated in vivo after experimental infection with RV-A16. RV-A16 epitopes constituted species-specific and pan-species varieties, together providing ˜90% coverage of the US population. Cross-reactivity was evidenced for RV-A16 and RV-A39.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: July 30, 2019
    Assignees: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
    Inventors: Judith Ann Woodfolk, Lyndsey M. Muehling, William W. Kwok, Duy Tran Mai