Patents by Inventor Lynn A. deLearie

Lynn A. deLearie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for manufacturing DTPA-bis amide magnetic resonance imaging
    Patent number: 5508388
    Abstract: Processes for manufacturing diethylenetriaminepentaacetic acid ("DTPA") bis(amide) magnetic resonance imaging ("MRI") agents are disclosed. Specifically, processes for manufacturing [N,N"-Bis[N-(2-methoxyethyl)carbamoylmethyl]diethylenetriamine-N,N',N"-tri acetato]gadolinium(III) are disclosed.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: April 16, 1996
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Lynn deLearie, Wayne H. Lin, Dennis A. Moore, David H. White
  • 19F magnetic resonance imaging agents which include a nitroxide moiety
    Patent number: 5362477
    Abstract: Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize .sup.19 F magnetic resonance contrast media having enhanced .sup.19 F relaxivity. Fluorine-containing compounds having enhanced .sup.19 F relaxation properties resulting from direct association with an unpaired spin are disclosed. The fluorine-containing compound is associated with the unpaired spin by covalent attachment of a stable free radical, by complexation of a fluorinated complexing agent with a paramagnetic metal ion, or by salt formation or charge neutralization of a paramagnetic ion.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: November 8, 1994
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Dennis A. Moore, Max D. Adams, William P. Cacheris, David H. White, Muthunadar P. Periasamy, Raghavan Rajagopalan, Lynn A. deLearie, Steven R. Woulfe
  • Hydrophilic free radicals for magnetic resonance imaging
    Patent number: 5264204
    Abstract: Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as magnetic resonance contrast media. Typical magnetic resonance contrast media within the scope of the present invention include stable hydrophilic free radicals having a hydrophilic moiety, such as polyhydroxyalkyl groups and heterocyclic amino-alcohols such as dihydroxypyrrolidine, dihydroxypiperidine, and trihydroxypiperidine, and a stable free radical moiety, such as a nitroxide, phenoxy, or phenoxazinyl free radical moiety.
    Type: Grant
    Filed: April 30, 1992
    Date of Patent: November 23, 1993
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: William P. Cacheris, T. Jeffrey Dunn, Lynn deLearie, Youlin Lin, Jeffrey A. Levine