Patents by Inventor Lynn A. Gennaro
Lynn A. Gennaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230047103Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.Type: ApplicationFiled: June 27, 2022Publication date: February 16, 2023Applicant: Genentech, Inc.Inventors: Lynn A. Gennaro, Yung-Hsiang Kao, Yonghua Zhang
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Patent number: 11371999Abstract: The description relates to a method and kits for determining the total carbonylation level on a polypeptide.Type: GrantFiled: November 19, 2018Date of Patent: June 28, 2022Assignees: University of Kansas, Genentech, Inc.Inventors: Anna Mah, Christian Schoeneich, Yi Yang, Di Gao, Lynn A. Gennaro
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Publication number: 20200157238Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.Type: ApplicationFiled: August 6, 2019Publication date: May 21, 2020Applicant: Genentech, Inc.Inventors: Lynn A. Gennaro, Yung-Hsiang Kao, Yonghua Zhang
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Publication number: 20190345258Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab.Type: ApplicationFiled: July 12, 2019Publication date: November 14, 2019Applicant: Genentech, Inc.Inventors: Lynn A. Gennaro, Yung-Hsiang Kao, Yonghua Zhang
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Publication number: 20190219590Abstract: The description relates to a method and kits for determining the total carbonylation level on a polypeptide.Type: ApplicationFiled: November 19, 2018Publication date: July 18, 2019Applicants: Genentech, Inc., University of KansasInventors: Anna Mah, Christian Schoeneich, Yi Yang, Di Gao, Lynn A. Gennaro
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Patent number: 9969811Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.Type: GrantFiled: October 19, 2017Date of Patent: May 15, 2018Assignee: Genentech, Inc.Inventors: Lynn A. Gennaro, Yung-Hsiang Kao, Yonghua Zhang
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Publication number: 20180037660Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.Type: ApplicationFiled: October 19, 2017Publication date: February 8, 2018Applicant: Genentech, Inc.Inventors: Lynn A. Gennaro, Yung-Hsiang Kao, Yonghua Zhang
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Publication number: 20180037662Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.Type: ApplicationFiled: October 19, 2017Publication date: February 8, 2018Applicant: Genentech, Inc.Inventors: Lynn A. Gennaro, Yung-Hsiang Kao, Yonghua Zhang
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Publication number: 20180037661Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.Type: ApplicationFiled: October 19, 2017Publication date: February 8, 2018Applicant: Genentech, Inc.Inventors: Lynn A. Gennaro, Yung-Hsiang Kao, Yonghua Zhang
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Patent number: 9815904Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.Type: GrantFiled: April 15, 2014Date of Patent: November 14, 2017Assignee: Genetech, Inc.Inventors: Lynn A. Gennaro, Yung-Hsiang Kao, Yonghua Zhang
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Publication number: 20140308277Abstract: The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.Type: ApplicationFiled: April 15, 2014Publication date: October 16, 2014Applicant: GENENTECH, INC.Inventors: Lynn A. Gennaro, Yung-Hsiang Kao, Yonghua Zhang