Abstract: An apparatus and method for assessing tension of a ligament in a patient's body with less reliance on a subjective feel of a human examiner.

Abstract: This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases.

Abstract: This invention relates to methods of measuring HIF expression and activity, as well as measuring inhibition of HIF following administration of an HIF inhibitor useful in treating HIF related diseases. The present invention further relates to methods of identifying individuals who will respond to HIF inhibitors. The invention also relates to methods of monitoring a patient response to a given dosage of an HIF inhibitor. The invention also includes assays and kits for performing the methods described herein.

Abstract: The present invention generally relates to methods of preselecting patients for treatment with an anti-VEGF therapy, anti-HIF-1 therapy or anti-thioredoxin therapy. Aspects of the invention combine methods of dynamic contrast enhanced-MRI and diffusion weighted-MRI for the detection of tumor histology. The methodology disclosed herein detects tissue blood volume, tumor vascularity, and abnormal capillary permeability, thereby determining tumor vascularity to determine whether a patient should be administered such therapy.

Abstract: An apparatus for removing an osteophyte includes an elongated member. A portion of the elongated member includes a blunt end. A burr extends from this portion at a location proximal to the blunt end. An alternative embodiment includes a generally tongue-shaped elongated member. The elongated member includes a first portion and a second portion that define a passageway. The second portion includes a blunt end. At least one of a post and a wall extend from the first portion. A burr is coupled the second portion and the passageway at a location proximal to the blunt end. The burr includes a base with a generally pie-slice shaped perimeter, and includes a generally convex surface extending from the base. The generally convex surface includes a smooth portion facing generally toward the blunt end and a perforated, non-smooth portion facing generally toward the first portion of the elongated member.

Abstract: Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the wortmannin analogs may be administered with other chemotherapeutic agents in the treatment of cancer.

Abstract: The hypoxia inducible factor-1 (HIF-1) transcription factor is an important regulator of the cellular response to hypoxia. The activity of HIF-1 is regulated by the level of the HIF-1? subunit, HIF-1?, which is rapidly degraded under normoxic conditions by the ubiquitin-proteasome pathway. HIF-1? levels increase under hypoxic conditions. Many human cancers also show constitutively increased HIF-1? levels. PX-478 or S-2-amino-3-[4?-N,N,-bis(2-chloroethyl)amino]phenyl propionic acid N-oxide dihydrochloride, is a novel anticancer agent, and is capably of decreasing both constitutive and hypoxia induced HIF-1? protein levels and HIF-1 transactivation in vitro and in vivo. In method embodiments, the administration of PX-478 is independent of the pathways of HIF-1? regulation involving the von Hippel-Lindau protein and p53. PX-478 causes an increase in polyubiquitinated HIF-1? levels due to inhibition of HIF-1? deubiquitination.

Abstract: This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases.

Abstract: The present invention is directed to a composition or formulation which includes an asymmetric disulfide which alone or in combination inhibits or interferes with cellular redox function, as well as a method of using same to restore normal cellular function. More specifically, the composition of the present invention are delivered to the patient over a period of time and interact with, interfere with, or inhibit abnormal cellular proliferation and restores or prevents inhibition of cellular apoptosis.

Abstract: This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases.

Abstract: An apparatus for removing an osteophyte is provided.

Abstract: An apparatus and method for assessing tension of a ligament in a patient's body with less reliance on a subjective feel of a human examiner are provided.

Abstract: The present invention is directed to a composition or formulation which includes an asymmetric disulfide which alone or in combination inhibits or interferes with cellular redox function, as well as a method of using same to restore normal cellular function. More specifically, the composition of the present invention interacts with, interferes with or inhibits abnormal cellular proliferation and restores or prevents inhibition of cellular apoptosis.

Abstract: An absorbent article includes a garment having opposite waist regions separated by a crotch region. At least one of the waist regions includes an expansion panel adapted to elongate in a direction substantially perpendicular to the longitudinal axis of the garment. The absorbent article also includes a pair of elastomeric strap members that are adapted to attach to the waist regions.

Abstract: The present invention is directed to a composition or formulation which includes an asymmetric disulfide which alone or in combination inhibits or interferes with cellular redox function, as well as a method of using same to restore normal cellular function. More specifically, the composition of the present invention interacts with, interferes with or inhibits abnormal cellular proliferation and restores or prevents inhibition of cellular apoptosis.

Abstract: The present invention is directed to a composition or formulation which inhibits or interferes with cellular redox function, and method of using same to restore normal cellular function. More specifically, the composition of the present invention interferes with or inhibits abnormal cellular proliferation and//restores or cellular apoptosis.

Abstract: An absorbent article includes a moisture barrier, a bodyside liner bonded to the moisture barrier, and an absorbent structure disposed between the bodyside liner and moisture barrier. Elasticized bumpers which function as three-dimensional physical barriers to liquid movement are disposed in the margins of the article. The elasticized bumpers include an internal barrier structure and an elasticized cover disposed over the internal barrier structure and bonded to one of the margins. In particular embodiments, the elasticized cover is formed of a hydrophobic material, is unadhered to the internal barrier structure, and/or is comprised of elastic strands of variable degrees of power.

Abstract: An absorbent article includes a generally reduced length absorbent assembly positioned between a moisture barrier and a bodyside liner. The moisture barrier and the bodyside liner extend beyond the absorbent assembly and define at least one waist region with a length dimension greater than about 10 centimeters. A moisture control layer is present in from about 25 to 100 percent of the area of the first waist region. The moisture control layer is configured to accommodate liquid that may be present in the waist region as a result of condensation or perspiration and also limit the transport of liquid from the absorbent assembly into the waist region.

Abstract: An absorbent article includes a moisture barrier, a bodyside liner bonded to the moisture barrier, and an absorbent structure disposed between the bodyside liner and moisture barrier. Elasticized bumpers which function as three-dimensional physical barriers to liquid movement are disposed in the margins of the article. The elasticized bumpers include an internal barrier structure and an elasticized cover disposed over the internal barrier structure and bonded to one of the margins. In particular embodiments, the elasticized cover is formed of a hydrophobic material, is unadhered to the internal barrier structure, and/or is comprised of elastic strands of variable degrees of power.

Abstract: An absorbent article includes a fastening system having first and second buttons bonded to an elastic strap member in respective first and second end regions. The straps are adapted to attach to a garment and maintain the garment in place during use. Reinforcement members are provided within reinforcement zones surrounding the attachment locations of each of the buttons. The reinforcement members locally stabilize the strap member near the attachment locations to minimize or eliminate rolling and twisting of the sides of the strap members during use.