Patents by Inventor Lynn Bry
Lynn Bry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20260240919Abstract: Disclosed are methods and compositions for the prevention and treatment of dysbiosis and associated conditions. In particular, described herein are microbial consortia, including monotherapies or minimal microbial consortia, that can prevent and/or cure dysbiosis and associated conditions. In certain embodiments, the therapy comprises Subdoligranulum variabile. In certain embodiments, the microbial consortia comprise certain members of the taxa Clostridiales, Bacteroidetes, Prevotella, and/or Parabacteroides.Type: ApplicationFiled: February 3, 2026Publication date: August 20, 2026Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Talal A. CHATILA, Azza ABDEL-GADIR, Emmanuel STEPHEN VICTOR, Rima RACHID, Lynn BRY, Georg GERBER
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Patent number: 11666611Abstract: Described herein are methods and compositions for the use of treating and/or preventing Clostridium difficile infections, including recurrent C. difficile infections, in a subject. Aspects of the technology relate to administering to a subject in need thereof a composition comprising a defined therapeutic microbiota comprising, e.g. Clostridial species. Also described herein are biomarker profiles, including a biomarker profile comprising two groups of Clostridial species, that is predictive of the likelihood of recurrent C. difficile infection and/or susceptibility to initial C. difficile infection.Type: GrantFiled: December 11, 2018Date of Patent: June 6, 2023Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Lynn Bry, Georg Gerber, Jessica Allegretti, Richard Lavin, Nicholas DiBenedetto
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Publication number: 20220193151Abstract: Disclosed are methods and compositions for the prevention and treatment of dysbiosis and associated conditions. In particular, described herein are microbial consortia, including monotherapies or minimal microbial consortia, that can prevent and/or cure dysbiosis and associated conditions. In certain embodiments, the therapy comprises Subdoligranulum variabile. In certain embodiments, the microbial consortia comprise certain members of the taxa Clostridiales, Bacteroidetes, Prevotella, and/or Parabacteroides.Type: ApplicationFiled: March 26, 2020Publication date: June 23, 2022Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Talal A. CHATILA, Azza ABDEL-GADIR, Emmanuel STEPHEN VICTOR, Rima RACHID, Lynn BRY, Georg GERBER
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Publication number: 20220184150Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: ApplicationFiled: July 21, 2021Publication date: June 16, 2022Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
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Publication number: 20220096566Abstract: Disclosed are methods and compositions for the prevention and treatment of dysbiosis and associated conditions. In particular, described herein are compositions of microbial consortia, including minimal microbial consortia, that can prevent and/or cure dysbiosis and associated conditions. In certain embodiments, the microbial consortia comprise certain members of the taxa Clostridiales, Bacteroidetes, Prevotella, and/or Parabacteroides.Type: ApplicationFiled: November 8, 2019Publication date: March 31, 2022Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Lynn BRY, Talal A. CHATILA, Georg GERBER, Azza ABDEL-GADIR, Rima RACHID
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Publication number: 20210069264Abstract: Described herein are methods and compositions for the use of treating and/or preventing Clostridium difficile infections, including recurrent C. difficile infections, in a subject. Aspects of the technology relate to administering to a subject in need thereof a composition comprising a defined therapeutic microbiota comprising, e.g. Clostridial species. Also described herein are biomarker profiles, including a biomarker profile comprising two groups of Clostridial species, that is predictive of the likelihood of recurrent C. difficile infection and/or susceptibility to initial C. difficile infection.Type: ApplicationFiled: December 11, 2018Publication date: March 11, 2021Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Lynn BRY, Georg GERBER, Jessica ALLEGRETTI, Richard LAVIN, Nicholas DIBENEDETTO
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Patent number: 10898527Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: GrantFiled: March 25, 2020Date of Patent: January 26, 2021Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
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Publication number: 20200246398Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: ApplicationFiled: September 12, 2019Publication date: August 6, 2020Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
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Publication number: 20200222473Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: ApplicationFiled: March 25, 2020Publication date: July 16, 2020Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
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Patent number: 10391131Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: GrantFiled: March 5, 2019Date of Patent: August 27, 2019Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
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Publication number: 20190192582Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: ApplicationFiled: March 5, 2019Publication date: June 27, 2019Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
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Patent number: 10265349Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: GrantFiled: November 2, 2017Date of Patent: April 23, 2019Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
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Publication number: 20180117097Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: ApplicationFiled: November 2, 2017Publication date: May 3, 2018Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
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Publication number: 20180117098Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: ApplicationFiled: November 2, 2017Publication date: May 3, 2018Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid
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Publication number: 20180117099Abstract: Disclosed are methods and compositions for the prevention and treatment of food allergy. In particular, described herein are microbial consortia, including minimal microbial consortia, that can prevent and/or cure food allergy. In certain embodiments, the consortia comprise certain members of the taxa Clostridiales and/or Bacteroidetes.Type: ApplicationFiled: November 2, 2017Publication date: May 3, 2018Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Talal A. Chatila, Lynn Bry, Georg Gerber, Azza Abdel-Gadir, Rima Rachid