Abstract: This disclosure relates to an electrified vehicle having a cabin pre-cooling strategy for managing battery and cabin cooling loads. A corresponding method is also disclosed. An example electrified vehicle includes a battery for propulsion, a cabin, a thermal management system configured to thermally condition both the battery and the cabin, and a controller configured to follow a cabin pre-cooling strategy to pre-cool the cabin when an expected cooling load of the battery, if the electrified vehicle were to be driven in present conditions, exceeds an upper battery cooling load threshold.

Abstract: This disclosure relates to an electrified vehicle having a cabin pre-cooling strategy for managing battery and cabin cooling loads. A corresponding method is also disclosed. An example electrified vehicle includes a battery for propulsion, a cabin, a thermal management system configured to thermally condition both the battery and the cabin, and a controller configured to follow a cabin pre-cooling strategy to pre-cool the cabin when an expected cooling load of the battery, if the electrified vehicle were to be driven in present conditions, exceeds an upper battery cooling load threshold.

Abstract: An ankle flexion and extension machine including a lower leg backing beam having upper and lower ends; a support arm cantilevering from the lower leg backing beam; an arm mounting pivot joint interconnecting the lower leg backing beam's lower end and the support arm's proximal end; a foot plate; a plate mounting pivot joint interconnecting the foot plate and the support arm's distal end, the plate mounting pivot joint being adapted for facilitating dorsiflecting and plantarflecting pivoting movements of the foot plate with respect to the lower leg backing beam; a reversible electric motor connected operatively to the foot plate, the reversible electric motor being adapted for driving the pivoting movement of the foot plate; a floor support base; and a triangulating frame supporting the lower leg backing beam, the support arm and the foot plate over the floor support base.

Abstract: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.

Abstract: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.

Abstract: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM -utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.

Abstract: The invention relates to a product and method for dispensing and packaging items comprising at least two nestable complementary components. The complementary components are provided in stacks where each stack comprises a nested portion of each of the complementary components. One stack will have one complementary component located on the top end of the stack and the other complementary component will be present on the bottom end of that stack. As presented for use in a carton, each stack will have a different complementary component on the respective top end of the stack. A user will select a complementary component from each stack to provide a completed item for use. The invention is particularly suited for lidded cups or containers where the cups or containers and lids are packaged together for complementary use.

Abstract: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.

Abstract: A cable brake system for deployments of cable comprising: a frame configured to be mounted on a ship; a repeater supporting track mounted longitudinally to the frame, the supporting track being configured for slidingly supporting a plurality of repeaters; a spool positioned exterior to the frame, the spool having the cable wrapped therearound and being capable of supplying the cable to an interior of the frame; at least one planar surface on an interior of the frame, the planar surface being positioned approximately parallel to the repeater supporting track; and a plurality of brake sub-assemblies being supported by the planar surface in a manner so as to establish a serpentine path for the cable and to impart variable frictional resistance to the cable.

Abstract: The invention relates to a product and method for dispensing and packaging items comprising at least two nestable complementary components. The complementary components are provided in stacks where each stack comprises a nested portion of each of the complementary components. One stack will have one complementary component located on the top end of the stack and the other complementary component will be present on the bottom end of that stack. As presented for use in a carton, each stack will have a different complementary component on the respective top end of the stack. A user will select a complementary component from each stack to provide a completed item for use. The invention is particularly suited for lidded cups or containers where the cups or containers and lids are packaged together for complementary use.