Abstract: The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.

Abstract: A disclosed method includes retrieving device trajectory data, and monitoring a path trajectory from trajectory data of a first device relative to another device. An alert signal is then transmitted if the path trajectory of the first device is within a threshold trajectory of another device. A device is also disclosed, which is configured to transmit an alert signal, and receive a response associated with a device proximate to an anticipated path of the device. The device then determines an accessibility of the anticipated path based on the response. In another aspect, a device is disclosed, which is configured to detect signals corresponding to devices proximate to the device, and further configured to transition the device to a prioritized state according to a characterization of proximate devices ascertained from the signal. The device then provides an alert when the device transitions into the prioritized state.

Abstract: The meal kit container of the present invention contains a disposable package which an animal can be feed by using a complete ready-to-use animal meal kit that can be disposed of after use. The invention comprises a meal kit whose components consist of a heat sealed locking closure pouch sufficient to store dry animal food, a locking closure pouch sufficient to hold water and a heat sealed pouch sufficient to hold an edible animal cookie or similar animal treat.