Patents by Inventor Lynn H. Caporale

Lynn H. Caporale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inverse solid phase synthesis
    Patent number: 5767238
    Abstract: This invention relates to a method of inverse solid phase synthesis in which reactants are reacted in solution and a solid phase matrix is used to separate unreacted reactants from desired product.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 16, 1998
    Assignee: CombiChem, Inc.
    Inventor: Lynn H. Caporale
  • Parathyroid hormone antagonists with enhanced metabolic properties
    Patent number: 5001223
    Abstract: The present invention relates to the use of peptide hormone analogues as inhibitors of their respective naturally occurring peptide hormone. The structure of the peptide hormone analogues is exemplified by parathyroid hormone wherein Phe.sup.7 is substituted by NMePhe, D-Phe, desamino Phe, or Met.sup.8 is substituted by NMeMet.
    Type: Grant
    Filed: March 2, 1989
    Date of Patent: March 19, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Michael Rosenblatt, Lynn H. Caporale, Michael Chorev
  • Parathyroid hormone antagonists with simplified synthetic methodology
    Patent number: 4771124
    Abstract: The present invention relates to the use of peptide hormone analogues as inhibitors of their respective naturally occurring peptide hormone and methods of synthesis of such analogues. The structure of the peptide hormone analogues is exemplified by parathyroid hormone wherein Trp.sup.23 is substituted by L-Phe or other hydrophobic amino acids such as Leu, Nle, Val, Tyr, beta-napthylalanine and alpha-napthylalanine.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: September 13, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Michael Rosenblatt, Lynn H. Caporale, Ruth F. Nutt, Jay J. Levy, Michael Chorev